Results 61 to 70 of about 13,300 (205)
Land Degradation &Development, EarlyView.ABSTRACT Urban soils are increasingly affected by degradation, compaction, pollution, and water limitation, which can constrain plant performance and the functioning of urban green spaces. Rhizosphere microbiome transplantation (RMT), which transfers entire microbial communities from donor plants to target species, has emerged as a potential ...
Magdalena Urbaniak +2 more
wiley +1 more source
Open and compressed conformations of Francisella tularensis ClpP
Proteins: Structure, Function, and Bioinformatics, 2016 ABSTRACTCaseinolytic proteases are large oligomeric assemblies responsible for maintaining protein homeostasis in bacteria and in so doing influence a wide range of biological processes. The functional assembly involves three chaperones together with the oligomeric caseinolytic protease catalytic subunit P (ClpP).
Díaz-Sáez, Laura +2 more
openaire +4 more sources
BMC Microbiology, 2010 Background Legionella pneumophila, the intracellular bacterial pathogen that causes Legionnaires' disease, exhibit characteristic transmission traits such as elevated stress tolerance, shortened length and virulence during the transition from the ...
Zhang Qin-fen +6 more
doaj +1 more source
The FGF/FGFR System in the Biology and Therapeutic Landscape of Pediatric CNS Tumors
Medicinal Research Reviews, EarlyView.ABSTRACT Central nervous system (CNS) tumors are the most common solid malignancies in children, comprising a highly heterogeneous group of neoplasms defined by distinct molecular alterations and clinical behaviors. Advances in molecular genetics have underscored the relevance of specific signaling pathways in driving pediatric tumorigenesis, among ...
Serena Filiberti +6 more
wiley +1 more source
Chemistry & Biology, 2010 In ClpXP and ClpAP complexes, ClpA and ClpX use the energy of ATP hydrolysis to unfold proteins and translocate them into the self-compartmentalized ClpP protease. ClpP requires the ATPases to degrade folded or unfolded substrates, but binding of acyldepsipeptide antibiotics (ADEPs) to ClpP bypasses this requirement with unfolded proteins.
Li, Dominic Him Shun +9 more
openaire +2 more sources
Discrete Dynamics in Nature and Society, 2021 The effective implementation of cultivated land protection policies (CLPP) has important practical significance for improving China’s food security and ecological security.
Xinhai Lu, Yanwei Zhang, Yucheng Zou
doaj +1 more source
Redox BiologyVascular smooth muscle cells (VSMCs), known for their remarkable lifelong phenotypic plasticity, play a pivotal role in vascular pathologies through their ability to transition between different phenotypes. Our group discovered that the deficiency of the
F. Paredes +11 more
semanticscholar +1 more source
Clinical Cancer Research, 2022 Purpose: Novel therapeutic targets are critical to unravel for the most common primary brain tumor in adults, glioblastoma (GBM). We have identified a novel synthetic lethal interaction between ClpP activation and HDAC1/2 inhibition that converges on GBM
T. Nguyen +10 more
semanticscholar +1 more source
Proteins: Structure, Function, and Bioinformatics, EarlyView.ABSTRACT Proteins are built from modular domains that serve as fundamental units of structure and evolution. While individual domains have been extensively cataloged, their collective distribution across the lineages of life has remained poorly resolved.
Rui Guo +5 more
wiley +1 more source
Data in Brief, 2021 Proteolytic subunit of the caseinolytic protease system of Plasmodium knowlesi (Pk-ClpP; EC 3.4.21.92) is considered a viable target for antimalarial drug development to eradicate P.
Raimalynah Abd Razak +6 more
doaj +1 more source