Results 61 to 70 of about 13,032 (201)
Purification of the Caseinolytic protease ClpP.
, 2022 The caseinolytic protease P (ClpP) is an essential protein for bacteria and bacterial derived organelles. It belongs to the AAA+ family of proteases and has proteolytic activity, thereby, it plays an important role in protein digestion. This protease is involved in essential processes such as, cellular regulatory mechanisms, protein homeostasis ...
Pedrós Manzanares, Laura +1 more
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Molecular NeurodegenerationBackground Mitochondrial dysfunction and α-Synuclein (αSyn) aggregation are defining features of Parkinson’s disease (PD), yet the mechanistic link between them remains poorly understood.
Di Hu, Xiaoyan Sun, Xin Qi
doaj +1 more source
Alpha-synuclein suppresses mitochondrial protease ClpP to trigger mitochondrial oxidative damage and neurotoxicity [PDF]
, 2019 Both α-Synuclein (αSyn) accumulation and mitochondrial dysfunction have been implicated in the pathology of Parkinson's disease (PD). Although studies suggest that αSyn and its missense mutant, A53T, preferentially accumulate in the mitochondria, the ...
Zarabi, S +9 more
core +1 more source
Discrete Dynamics in Nature and Society, 2021 The effective implementation of cultivated land protection policies (CLPP) has important practical significance for improving China’s food security and ecological security.
Xinhai Lu, Yanwei Zhang, Yucheng Zou
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Targeting the Mitochondrial Protease ClpP for Anticancer Therapy
Journal of Medicinal ChemistryAbstract Cancer cells depend on mitochondrial reprogramming for growth, but this raises reactive oxygen species (ROS), increasing reliance on protein quality control (PQC) repair mechanisms. The mitochondrial proteome is maintained through a robust PQC composed of chaperones and proteases, including the mitochondrial matrix protease ...
Zhongli Xu +9 more
openaire +2 more sources
clpP full and partial duplication
, 2014 Phylip alignment of the full clpP coding sequence for Campanulastrum americanum as well as the partial duplication of the first ...
Karen B Barnard-Kubow (3326205) +5 more
core +1 more source
LONP1 and ClpP cooperatively regulate mitochondrial proteostasis for cancer cell survival
Oncogenesis, 2021 Mitochondrial proteases are key components in mitochondrial stress responses that maintain proteostasis and mitochondrial integrity in harsh environmental conditions, which leads to the acquisition of aggressive phenotypes, including chemoresistance and ...
Yu Geon Lee +8 more
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The Bacterial ClpXP-ClpB Family Is Enriched with RNA-Binding Protein Complexes
Cells, 2022 In the matrix of bacteria/mitochondria/chloroplasts, Lon acts as the degradation machine for soluble proteins. In stress periods, however, proteostasis and survival depend on the strongly conserved Clp/Hsp100 family. Currently, the targets of ATP-powered
Georg Auburger, Jana Key, Suzana Gispert
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Ecology and Evolution, Volume 16, Issue 10, October 2026.We sequenced and characterized the complete chloroplast genomes of five Ulmus pumila cultivars, which possess typical circular quadripartite structures (159,391–159,769 bp, 35.47%–35.56% GC) encoding 131–133 genes and identified abundant SSRs, long repeats, and core hypervariable molecular markers (trnH‐GUG_psbA, ndhF_rpl32), while IR boundary and ...
Ning Wang +8 more
wiley +1 more source
Data in Brief, 2021 Proteolytic subunit of the caseinolytic protease system of Plasmodium knowlesi (Pk-ClpP; EC 3.4.21.92) is considered a viable target for antimalarial drug development to eradicate P.
Raimalynah Abd Razak +6 more
doaj +1 more source