Results 61 to 70 of about 18,307 (208)
Proteins: Structure, Function, and Bioinformatics, EarlyView.ABSTRACT Proteins are built from modular domains that serve as fundamental units of structure and evolution. While individual domains have been extensively cataloged, their collective distribution across the lineages of life has remained poorly resolved.
Rui Guo +5 more
wiley +1 more source
Impact of soil management on the functional activity of microbial communities associated to cork oak rhizosphere [PDF]
, 2007 The microbial ecology of cork oak rhizosphere was investigated using the Biolog community level physiological profile (CLPP) that provides a unique metabolic fingerprint helpful for the characterization of complex microbial communities.
Caredda, Marco +3 more
core
A Simple Fragment of Cyclic Acyldepsipeptides Is Necessary and Sufficient for ClpP Activation and Antibacterial Activity [PDF]
, 2014 The development of new antibacterial agents, particularly those with unique biological targets, is essential to keep pace with the inevitable emergence of drug resistance in pathogenic bacteria.
Carney, Daniel W. +5 more
core +1 more source
Cancer pain: current practice and emerging targets
British Journal of Pharmacology, EarlyView.Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye +5 more
wiley +1 more source
CLPP deficiency ameliorates neurodegeneration caused by impaired mitochondrial protein synthesis
Brain, 2022 Abstract Mitochondria are essential organelles found in every eukaryotic cell, required to convert food into usable energy. Therefore, it is not surprising that mutations in either mtDNA or nuclear DNA-encoded genes of mitochondrial proteins cause diseases affecting the oxidative phosphorylation system, which are heterogeneous from a ...
Anastasia Rumyantseva +2 more
openaire +2 more sources
The Bacterial ClpXP-ClpB Family Is Enriched with RNA-Binding Protein Complexes
Cells, 2022 In the matrix of bacteria/mitochondria/chloroplasts, Lon acts as the degradation machine for soluble proteins. In stress periods, however, proteostasis and survival depend on the strongly conserved Clp/Hsp100 family. Currently, the targets of ATP-powered
Georg Auburger, Jana Key, Suzana Gispert
doaj +1 more source
Dissection of Mitochondrial Function via Chemical Perturbation and Single‐Cell Profiling
Cell Proliferation, EarlyView.We establish a systematic framework to dissect mitochondrial function at the module level by combining targeted chemical perturbations with scRNA‐seq. This approach reveals shared and module‐specific programs linking mitochondrial activity to mito‐nuclear communication, stress response, and cell cycle, highlighting the tight coupling between ...
Hao Luo +4 more
wiley +1 more source
Cohesin cleavage by separase is enhanced by a substrate motif distinct from the cleavage site. [PDF]
, 2019 Chromosome segregation begins when the cysteine protease, separase, cleaves the Scc1 subunit of cohesin at the metaphase-to-anaphase transition.
Asfaha, Jonathan B +6 more
core +1 more source
Segregation of molecules at cell division reveals native protein localization [PDF]
, 2014 We introduce a non-intrusive method exploiting post-division single-cell variability to validate protein localization. The results show that Clp proteases, widely reported to form biologically relevant foci, are in fact uniformly distributed inside ...
Baker, Tania A. +4 more
core +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Placental mitochondrial adaptation to gestational hypoxia. Hypoxic pregnancy in sheep increases placental insulin like growth factor 2 (IGF2) signalling (1), which is associated with a shift in capacity away from β‐oxidation (2) and complex I‐mediated respiration (3), while maintaining total oxidative phosphorylation capacity (4).
Wen Tong +18 more
wiley +1 more source