Results 81 to 90 of about 10,075 (175)

Spatial optimization of cultivated land protection policy implementation effect in China using a geographically optimal zones-based heterogeneity model

GIScience & Remote Sensing
Cultivated land protection policies (CLPP) are crucial for safeguarding China's food security and promoting sustainable agricultural development; however, their implementation is prone to deviations and divergence from intended objectives.
Yanwei Zhang, Ruixin Chen, Xinhai Lu, Houbao Fan, Li Wang, Bo Xia, Douglas Baker   +6 more
doaj   +1 more source

Mechanism of allosteric activation in human mitochondrial ClpP protease

Proceedings of the National Academy of Sciences
Abstract Human ClpP protease contributes to mitochondrial protein quality control by degrading misfolded proteins. ClpP is overexpressed in cancers such as acute myeloid leukemia (AML), where its inhibition leads to the accumulation of damaged respiratory chain subunits and cell death.
Monica M. Goncalves, Adwaith B. Uday, Taylor J. B. Forrester, S. Quinn W. Currie, Angelina S. Kim, Yue Feng, Yulia Jitkova, Algirdas Velyvis, Robert W. Harkness, Matthew S. Kimber, Aaron D. Schimmer, Natalie Zeytuni, Siavash Vahidi   +12 more
openaire   +2 more sources

Structural insights into the Clp protein degradation machinery

mBio
The Clp protease system is important for maintaining proteostasis in bacteria. It consists of ClpP serine proteases and an AAA+ Clp-ATPase such as ClpC1.
Xiaolong Xu, Yanhui Wang, Wei Huang, Danyang Li, Zixin Deng, Feng Long   +5 more
doaj   +1 more source

Discovery of coniferaldehyde as an inhibitor of caseinolytic protease to combat Staphylococcus aureus infections

Molecular Medicine
The rising incidence of methicillin-resistant Staphylococcus aureus (MRSA) poses a significant threat to global public health, highlighting the urgent need for novel therapies and treatments in clinical settings.
Shufang Li, Yan Zhang, Jianfeng Wang, Hongfa Lv, Hongxia Ma, Lingcong Kong, Yonglin Zhou, Jingmin Gu, Wei Li, Qiaoling Zhang   +9 more
doaj   +1 more source

Harmaline to Human Mitochondrial Caseinolytic Serine Protease Activation for Pediatric Diffuse Intrinsic Pontine Glioma Treatment

Pharmaceuticals
Diffuse intrinsic pontine glioma (DIPG), affecting children aged 4–7 years, is a rare, aggressive tumor that originates in the pons and then spreads to nearby tissue.
Morena Miciaccia, Francesca Rizzo, Antonella Centonze, Gianfranco Cavallaro, Marialessandra Contino, Domenico Armenise, Olga Maria Baldelli, Roberta Solidoro, Savina Ferorelli, Pasquale Scarcia, Gennaro Agrimi, Veronica Zingales, Elisa Cimetta, Simone Ronsisvalle, Federica Maria Sipala, Paola Loguercio Polosa, Cosimo Gianluca Fortuna, Maria Grazia Perrone, Antonio Scilimati   +18 more
doaj   +1 more source

Community-level physiological profiling analyses show potential to identify the copiotrophic bacteria present in soil environments.

PLoS ONE, 2017
Community-level physiological profiling (CLPP) analyses from very diverse environments are frequently used with the aim of characterizing the metabolic versatility of whole environmental bacterial communities. While the limitations of the methodology for
Salvador Lladó, Petr Baldrian
doaj   +1 more source

Tripartite evolutionary game and simulation analysis of cultivated land protection policies implementation in China

Cogent Food & Agriculture
China has established the world’s most stringent cultivated land protection policies (CLPP) system. However, the key to policy is its implementation.
Yanwei Zhang, Ruixin Chen, Xinhai Lu, Yucheng Zou   +3 more
doaj   +1 more source

Protein degradation by a component of the chaperonin‐linked protease ClpP

Genes to Cells
AbstractIn cells, proteins are synthesized, function, and degraded (dead). Protein synthesis (spring) is important for the life of proteins. However, how proteins die is equally important for organisms. Proteases are secreted from cells and used as nutrients to break down external proteins. Proteases degrade unwanted and harmful cellular proteins.
Fumihiro Ishikawa, Michio Homma, Genzoh Tanabe, Takayuki Uchihashi   +3 more
openaire   +2 more sources

DISSECTING THE ROLE OF CLPP IN MULTIPLE MYELOMA

, 2022
Despite the efficacy of targeted treatments, multiple myeloma (MM) is still incurable, urging to identify novel vulnerabilities to design more effective therapies. Mitochondria are emerging therapeutic targets in oncology for their crucial role not only as cellular powerhouses, but also in signalling, redox homeostasis, initiation of apoptosis ...
openaire   +1 more source

ClpP [PDF]

Science-Business eXchange, 2013
openaire   +1 more source