Results 81 to 90 of about 13,032 (201)

Chemical Activators of ClpP: Turning Jekyll into Hyde

Chemistry & Biology, 2011
Casein lytic peptidase P (ClpP) is a serine peptidase that, when coupled to its cognate ATPase, facilitates the controlled degradation of both damaged and unwanted proteins in bacteria. In this issue of Chemistry & Biology, Leung et al. (2011) report a small molecule screen against ClpP, from which they identified four structurally distinct compounds ...
openaire   +2 more sources

Development of prediction model for risks of musculoskeletal chronic lumbopelvic pain in Indian women

Scientific Reports
Chronic lumbopelvic pain (CLPP) and its associated disabilities significantly affect women's social, professional, and personal lives. However, the specific factors contributing to CLPP in women remain unclear. To address this gap, this prospective cross-
Jasmine Kaur Chawla, Priyanka Sushil, Pragya Kumar, Manish Singh, Roshani Sharma   +4 more
doaj   +1 more source

Complete Chloroplast Genome of Nepeta griffithii and Comparative Genomics of 10 Nepeta Species

Ecology and Evolution, Volume 16, Issue 10, October 2026.
This study reports the first complete chloroplast genome of Nepeta griffithii and compares it with nine previously published Nepeta plastomes. Comparative analyses revealed conserved plastome structure, gene content, inverted repeat boundaries, codon usage, and SSR distribution across the genus, while identifying highly variable loci for future ...
Xinyi Li, Abdul Sammad, Sayed Afzal Shah, Jiahui Sun, Aman Karim, Bartholomew Yir‐erong, Xiaoxuan Tian, Abdullah   +7 more
wiley   +1 more source

Cell Division Protein FtsZ Is Unfolded for N-Terminal Degradation by Antibiotic-Activated ClpP

mBio, 2020
Antibiotic acyldepsipeptides (ADEPs) deregulate ClpP, the proteolytic core of the bacterial Clp protease, thereby inhibiting its native functions and concomitantly activating it for uncontrolled proteolysis of nonnative substrates.
Nadine Silber, Stefan Pan, Sina Schäkermann, Christian Mayer, Heike Brötz-Oesterhelt, Peter Sass   +5 more
doaj   +1 more source

First Report of blaCTX‐M‐15 in a Marine Thermotolerant Enterobacter Isolate From Bangladesh: Genomic Insights Into Halotolerance and Antimicrobial Resistance

MicrobiologyOpen, Volume 15, Issue 5, October 2026.
Marine‐derived Enterobacter kobei, exhibiting thermotolerance and salt tolerance, is ESBL‐producing and harbors AMR genes (blaCTX‐M‐15, qnrS1) and mobile genetic elements, indicating environmental spread of antimicrobial resistance. ABSTRACT Marine ecosystems are becoming important reservoirs for antimicrobial resistance (AMR). However, genomic data on
Md. Arifur Rahman, Rafid Muntasir Ul Azam, Md. Sazib Hossain, Samina Momtaz, Anowara Begum, Munawar Sultana   +5 more
wiley   +1 more source

Healthy Participant Versus Patient Selection for Clinical Pharmacology Studies in Small‐Molecule Oncology Drug Development

Clinical and Translational Science, Volume 19, Issue 11, November 2026.
Paridhi Gupta, Zheyi Hu, Li Zhu, Lora Hamuro   +3 more
wiley   +1 more source

Osteomyelitis: Epidemiology, Classification, Pathophysiology, Clinical Features, Diagnosis, and Management

MedComm, Volume 7, Issue 10, October 2026.
The immunosuppressive in OM Staphylococcus aureus employs multiple physical barriers to evade host immunity during skeletal infection, including biofilm formation on implant surfaces and necrotic bone tissues, invasion into the osteocyte lacuno‐canalicular network (OLCN), intracellular persistence within osteoblasts, osteoclasts, and osteocytes, and ...
Qingqiang Lei, Liangbin Lin, Peidong Pu, Jie Chen, Xianchao Su, Shubao Liu, Yanli Tong, Hui Yu   +7 more
wiley   +1 more source

????????????????????? ?????????????????? ??????????????? LONP1??? ClpP??? ?????? ??????

, 2020
Department of Biological SciencesHostile microenvironmental conditions within tumor masses, such as nutrient deprivation, oxygen limitation, high metabolic demand, and oxidative stress are provoking an adaptive mechanism.
Nam, Yeji
core  

ClpAP proteolysis does not require rotation of the ClpA unfoldase relative to ClpP

eLife, 2020
AAA+ proteases perform regulated protein degradation in all kingdoms of life and consist of a hexameric AAA+ unfoldase/translocase in complex with a self-compartmentalized peptidase.
Sora Kim, Kristin L Zuromski, Tristan A Bell, Robert T Sauer, Tania A Baker   +4 more
doaj   +1 more source

Universal and Lineage‐Specific Patterns in the Distribution of ECOD Domain Homology Groups Across Superkingdoms

Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 10, Page 1644-1657, October 2026.
ABSTRACT Proteins are built from modular domains that serve as fundamental units of structure and evolution. While individual domains have been extensively cataloged, their collective distribution across the lineages of life has remained poorly resolved.
Rui Guo, Jimin Pei, Jing Zhang, Qian Cong, Nick V. Grishin, R. Dustin Schaeffer   +5 more
wiley   +1 more source