Results 81 to 90 of about 13,300 (205)
Cells, 2022 Human Perrault syndrome (PRLTS) is autosomal, recessively inherited, and characterized by ovarian insufficiency with hearing loss. Among the genetic causes are mutations of matrix peptidase CLPP, which trigger additional azoospermia.
J. Key +13 more
semanticscholar +1 more source
Cancer Nexus, Volume 2, Issue 3, July 2026.ABSTRACT Inflammatory bowel disease (IBD), primarily Crohn's disease and ulcerative colitis, is a chronic relapsing inflammatory disorder of the gastrointestinal tract and an important risk factor for IBD‐associated cancer. Increasing evidence suggests that gut microbiota dysbiosis, epithelial barrier dysfunction, and immune microenvironment remodeling
Xue Zhang +4 more
wiley +1 more source
Acta Biochimica et Biophysica SinicaCurrently, platinum agents remain the mainstay of chemotherapy for ovarian cancer (OC). However, cisplatin (DDP) resistance is a major reason for chemotherapy failure.
Kou Xinxin +3 more
doaj +1 more source
bioRxiv, 2022 Clp proteases are antibiotic and anticancer drug targets. Composed of the proteolytic core ClpP and a regulatory Clp-ATPase, the protease machinery is important for protein homeostasis and regulatory proteolysis.
Laura Reinhardt +7 more
semanticscholar +1 more source
Complete Chloroplast Genome of Cardamine microzyga and Phylogenetic Analysis
Ecology and Evolution, Volume 16, Issue 7, July 2026.This study reports the first complete chloroplast genome of Cardamine microzyga, a perennial herb from mountainous southwestern China. The genome is 154,661 bp in length with a typical quadripartite structure and contains 129 genes. Comparative genomic analyses identified several hypervariable regions (e.g., trnS‐GCU, rrn4.5S, ycf1) as promising DNA ...
Yongming Fan +7 more
wiley +1 more source
Ecology and Evolution, Volume 16, Issue 7, July 2026.In this study, we first sequenced and characterized the complete chloroplast genome of Aster lautureanus and conducted comprehensive analyses of genome structure, codon usage, repeat sequences, phylogeny, and divergence time. ABSTRACT The genus Aster represents an important group of flowering plants with complex evolutionary relationships, yet genomic ...
Qiaoyu Zhang +9 more
wiley +1 more source
Development of Antibiotics That Dysregulate the Neisserial ClpP Protease
ACS Infectious Diseases, 2020 Evolving antimicrobial resistance has motivated the search for novel targets and alternative therapies. Caseinolytic protease (ClpP) has emerged as an enticing new target since its function is conserved and essential for bacterial fitness, and because its inhibition or dysregulation leads to bacterial cell death.
Gursonika Binepal +14 more
openaire +3 more sources
Mitochondrial ClpP serine protease-biological function and emerging target for cancer therapy
Cell Death and Disease, 2020 Mitochondrial ClpP is a serine protease located in the mitochondrial matrix. This protease participates in mitochondrial protein quality control by degrading misfolded or damaged proteins, thus maintaining normal metabolic function. Mitochondrial ClpP is
K. Nouri, Yue Feng, A. Schimmer
semanticscholar +1 more source
Ecology and Evolution, Volume 16, Issue 7, July 2026.The complete plastid genome of Astrohibiscus caesius has a typical quadripartite structure (161,092 bp) and encodes 112 unique genes with an AT‐rich bias. Phylogenomic analysis confirms that Hibiscus is polyphyletic and Astrohibiscus forms a distinct lineage outside all major Hibiscus clades, providing whole‐plastome evidence supporting this monotypic ...
Rushan Yan +8 more
wiley +1 more source
Scientific ReportsChronic lumbopelvic pain (CLPP) and its associated disabilities significantly affect women's social, professional, and personal lives. However, the specific factors contributing to CLPP in women remain unclear. To address this gap, this prospective cross-
Jasmine Kaur Chawla +4 more
doaj +1 more source