Results 91 to 100 of about 13,300 (205)

Cell Division Protein FtsZ Is Unfolded for N-Terminal Degradation by Antibiotic-Activated ClpP

mBio, 2020
Antibiotic acyldepsipeptides (ADEPs) deregulate ClpP, the proteolytic core of the bacterial Clp protease, thereby inhibiting its native functions and concomitantly activating it for uncontrolled proteolysis of nonnative substrates.
Nadine Silber, Stefan Pan, Sina Schäkermann, Christian Mayer, Heike Brötz-Oesterhelt, Peter Sass   +5 more
doaj   +1 more source

Plastome Evolution and Codon Usage Dynamics in Argentina (Rosaceae): Phylogenomic Resolution and Adaptive Signatures

Ecology and Evolution, Volume 16, Issue 7, July 2026.
This study assembled chloroplast genomes for three Argentina species and compared them with 15 others to resolve long‐standing taxonomic issues. Phylogenomic analyses strongly supported the monophyly of Argentina and identified five major clades, while analyses of codon usage revealed that natural selection is the predominant force shaping codon ...
Guang‐Nan Zhang, Li‐Zhen Ling, Jie Tian, Shu‐Dong Zhang   +3 more
wiley   +1 more source

Accelerating Pediatric Oncology Drug Development: Advances in Clinical Pharmacology, Trial Design, Non‐Clinical Evidence, and Regulatory Science

The Journal of Clinical Pharmacology, Volume 66, Issue 7, July 2026.
Abstract Pediatric oncology drug development remains uniquely challenging due to the rarity and biological heterogeneity of childhood cancers, ethical considerations in trial conduct, and the limited feasibility of large, randomized studies. Despite these barriers, recent years have seen a notable acceleration in the approval of oncology therapies for ...
Ya‐Feng Wen, Xiaoning Wang, Sarandeep Boyanapalli, Lee Anderson, Thao Dang, Guan Xing, Marianna Calvet, Tiffany Hart, Sreeneeranj Kasichayanula, Xiaochen Zhao   +9 more
wiley   +1 more source

Protein degradation in bacteria: focus on the ClpP protease

Nippon Saikingaku Zasshi
Proteins in the cells are born (synthesized), work, and die (decomposed). In the life of a protein, its birth is obviously important, but how it dies is equally important in living organisms. Proteases secreted into the outside of cells are used to decompose the external proteins and the degradation products are taken as the nutrients.
Fumihiro, Ishikawa, Michio, Homma, Genzoh, Tanabe, Takayuki, Uchihashi   +3 more
openaire   +2 more sources

Cellular Senescence and Aging: Mechanisms, Disease Convergence, and Therapeutic Frontiers

MedComm, Volume 7, Issue 7, July 2026.
This schematic illustrates the hierarchical and interconnected nature of the primary molecular hallmarks of aging. The progression of aging is driven by a convergence of intrinsic molecular insults. Within the nucleus, genomic instability and telomere attrition trigger persistent DDR, accompanied by extensive epigenetic alterations.
Guowei Cai, Jia Ren, Li Wang, Yingying Wu, Huirui Wang, Xiaomeng Cao, Hao Shang, Xuben Hou, Yujiu Wang, Haibo Xue, Ting Dong   +10 more
wiley   +1 more source

Proteomic Analysis of Lactococcus lactis FM03 Under Prolonged Alkaline Stress

Environmental Microbiology, Volume 28, Issue 7, July 2026.
Overview of alkaline resistance mechanisms in Lactococcus lactis FM03. Sustained growth at pH 8 triggers extensive physiological remodelling, including activation of general stress response proteins, suppression of acid resistance, elevated amino acid production, altered cell wall biosynthesis, and doubling of the cell wall thickness.
Tamara A. L. Bendig, Tjakko Abee, Sjef Boeren, Eddy J. Smid, Oscar van Mastrigt   +4 more
wiley   +1 more source

Chemical Activators of ClpP: Turning Jekyll into Hyde

Chemistry & Biology, 2011
Casein lytic peptidase P (ClpP) is a serine peptidase that, when coupled to its cognate ATPase, facilitates the controlled degradation of both damaged and unwanted proteins in bacteria. In this issue of Chemistry & Biology, Leung et al. (2011) report a small molecule screen against ClpP, from which they identified four structurally distinct compounds ...
openaire   +2 more sources

Mitochondrial Dysfunction at the Crossroads of Necroptosis: Mechanisms, Molecular Mediators, and Therapeutic Opportunities

Journal of Cellular and Molecular Medicine, Volume 30, Issue 14, July 2026.
ABSTRACT The conceptual landscape of cell death has evolved beyond the traditional dichotomy of apoptosis and necrosis to encompass diverse regulated pathways including necroptosis, autophagy, ferroptosis, and pyroptosis. Necroptosis, a caspase‐independent inflammatory form of programmed cell death, has emerged as a critical driver of the pathogenesis ...
Fengxin Wang, Haiying Rui, Dandan Qin, Huaxiang Yu, Dan Zou, Wenyi Zou, Yuting Li, Ran Li, Yuguo Chen, Li Xue   +9 more
wiley   +1 more source

ClpAP proteolysis does not require rotation of the ClpA unfoldase relative to ClpP

eLife, 2020
AAA+ proteases perform regulated protein degradation in all kingdoms of life and consist of a hexameric AAA+ unfoldase/translocase in complex with a self-compartmentalized peptidase.
Sora Kim, Kristin L Zuromski, Tristan A Bell, Robert T Sauer, Tania A Baker   +4 more
doaj   +1 more source

KATP Channel Expression Determines ONC212 Sensitivity via Mitochondrial Dysfunction and PERK/ATF4/CHOP Activation in Glioblastoma

Journal of Cellular and Molecular Medicine, Volume 30, Issue 14, July 2026.
ABSTRACT Glioblastoma (GBM) exhibits profound metabolic plasticity and resistance to conventional therapies, partly driven by mitochondrial adaptability and stress response mechanisms. ONC212, a second‐generation imipridone, targets mitochondrial proteostasis, yet determinants of tumour sensitivity remain unclear.
Ahmet Taskesen, Ceyhan Hacioglu
wiley   +1 more source