Results 91 to 100 of about 10,075 (175)

The Effect of the Lysine Acetylation Modification of ClpP on the Virulence of Vibrio alginolyticus

Molecules
Acetylation modification has become one of the most popular topics in protein post-translational modification (PTM) research and plays an important role in bacterial virulence.
Shi Wang, Yingying Jiang, Weijie Zhang, Yingzhu Wei, Xing Xiao, Zhiqing Wei, Xiaoxin Wen, Yuhang Dong, Jichang Jian, Na Wang, Huanying Pang   +10 more
doaj   +1 more source

Chemical activation of mitochondrial ClpP to modulate energy metabolism of CD4+ T cell for inflammatory bowel diseases treatment

Cell Reports Medicine
Summary: Inflammatory bowel disease (IBD) is an autoimmune disorder, and despite the availability of multiple Food and Drug Administration (FDA)-approved therapies, current clinical needs remain unmet. In this study, we find that caseinolytic protease P (
Jiangnan Zhang, Yunhan Jiang, Dongmei Fan, Zhiqiang Qiu, Xinlian He, Song Liu, Linjie Li, Zhengyi Dai, Lidan Zhang, Ziyi Shu, Lili Li, Hu Zhang, Tao Yang, Youfu Luo   +13 more
doaj   +1 more source

Local and systemic delivery of mRNA encoding survivin-T34A by lipoplex for efficient colon cancer gene therapy

International Journal of Nanomedicine, 2019
Xueyan Zhang,1 Ke Men,1 Yuanfa Zhang,1 Rui Zhang,1 Li Yang,1 Xingmei Duan21State Key Laboratory of Biotherapy and Cancer Center/Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, People’s ...
Zhang X, Men K, Zhang Y, Zhang R, Yang L, Duan X   +5 more
doaj  

Repurposing Birabresib to target Gram‑positive bacteria. [PDF]

NPJ Antimicrob Resist
Koly HK, Razzaq R, Hossain T, Butzin NC.
europepmc   +1 more source

Bacterial warfare at the molecular level: <i>Pseudoalteromonas</i> sp. H2 disrupts <i>Vibrio splendidus</i> membrane integrity via ClpP-CheW2 regulation. [PDF]

Curr Res Microb Sci
Li Y, Dai F, Shi W, Sun Z, Hong H, Huang Y, Han Q, Zhang L, Zhang W.   +8 more
europepmc   +1 more source

The role of dordaviprone in the multidisciplinary management of diffuse midline glioma. [PDF]

Surg Neurol Int
Al Lawati AM, Al Suleimani MK, Al Rasbi IA, Al Hinai MA, Al Marbouai SB, Al Barhi HB, Al Lawati HM, Al Sideiri GS.   +7 more
europepmc   +1 more source

Mode of action guided metagenomic natural product discovery reveals convergent evolution of a ClpP-targeting motif. [PDF]

Nat Commun
Kan J, Spotton K, Morales-Amador A, Hernandez Y, Burian J, Panfil C, Ternei MA, Boer RE, Bhattacharjee A, Brady SF.   +9 more
europepmc   +1 more source

Structure-function analysis of the bacterial ClpE-ClpP AAA+ protease. [PDF]

J Biol Chem
De Rosa M, Maag L, Flemming D, Sinning I, Carroni M, Mogk A.   +5 more
europepmc   +1 more source

Polydatin as a natural ClpP modulator for combating methicillin-resistant <i>Staphylococcus aureus</i> infection. [PDF]

Front Cell Infect Microbiol
Qin Y, Yang J, Wang G, Yang L, Wang D, Luan Y.   +5 more
europepmc   +1 more source

Development and evaluation of mitochondria-targeted caseinolytic protease (ClpP) agonist chemical probes in in vitro breast cancer models. [PDF]

Med Chem Res
Hao X, Purohit G, Jayasinghe YP, Ronning DR, Khalimonchuk O, Trippier PC.   +5 more
europepmc   +1 more source