Results 91 to 100 of about 13,032 (201)

Discovery of CLPP-1071 as an Exceptionally Potent and Orally Efficacious Human ClpP Activator with Strong In Vivo Antitumor Activity

Journal of Medicinal Chemistry
Human sapiens caseinolytic protease P (ClpP) is essential for maintaining mitochondrial proteome homeostasis, and its activation is increasingly recognized as a promising cancer therapy strategy. Herein, based on structure-guided drug design, we discovered a series of potent ClpP activators by introducing a methyl group to the imipridone scaffold of ...
Beijing Chen, Mingyang Sun, Chun Zhang, Qi Huang, Dan Teng, Linghao Hu, Huicong Ma, Xinyi Lin, Zan Huang, Renzhao Gui, Xiaobei Hu, Lei Xu, Mingyue Zheng, Yubo Zhou, Jia Li, Mingliang Wang   +15 more
openaire   +2 more sources

De Novo Discovery of Bioactive Cyclic Peptides via Cellular Selection of Genetically Encoded Libraries

ChemBioChem, Volume 27, Issue 18, 28 September 2026.
Genetically encoded cyclic peptide libraries can be employed in cellular selection platforms to identify cyclic peptide inhibitors for therapeutic targets by directly selecting for desired biological activities. This review systematically summarizes representative studies and suggests future opportunities for using cellular selection for de novo cyclic
Linwei Yang, Abhijit Behera, Hannah J. Meyers, Tina Wang   +3 more
wiley   +1 more source

Impaired Mitochondrial Stress Response due to CLPP Deletion Is Associated with Altered Mitochondrial Dynamics and Increased Apoptosis in Cumulus Cells

, 2020
© 2020, Society for Reproductive Investigation. Caseinolytic peptidase P (CLPP) plays a central role in mitochondrial unfolded protein response (mtUPR) and is required for maintaining protein homeostasis in the mitochondria. Global germline Clpp deletion
Esencan, E., Seli, E., Wang, T., Jiang, Z., Zhang, M., Soylemez-Imamoglu, G.   +5 more
core   +1 more source

The Temporal Expression of Global Regulator Protein CsrA Is Dually Regulated by ClpP During the Biphasic Life Cycle of Legionella pneumophila

Frontiers in Microbiology, 2019
Legionella pneumophila, an environmental bacterium that parasitizes protozoa, is the causative pathogen of Legionnaires' disease. L. pneumophila adopts a distinct biphasic life cycle that allows it to adapt to environmental conditions for survival ...
Zhen-huang Ge, Zhen-huang Ge, Qin-sha Long, Qin-sha Long, Pei-bo Yuan, Pei-bo Yuan, Xin Pan, Dong Shen, Dong Shen, Yong-jun Lu, Yong-jun Lu   +10 more
doaj   +1 more source

Perrault syndrome type 3 caused by diverse molecular defects in CLPP [PDF]

, 2018
The maintenance of mitochondrial protein homeostasis (proteostasis) is crucial for correct cellular function. Recently, several mutations in the mitochondrial protease CLPP have been identified in patients with Perrault syndrome 3 (PRLTS3).
Dougan, David A., Zhan, Hanmiao, Saiyed, Tamanna, Truscott, Kaye N., Brodie, Erica J.   +4 more
core   +1 more source

Characterization of Gain-of-Function Mutant Provides New Insights into ClpP Structure

, 2016
ATP-dependent Clp protease (ClpP), a highly conserved serine protease in vast bacteria, could be converted into a noncontrollable enzyme capable of degrading mature proteins in the presence of acyldepsipeptides (ADEPs).
Hualiang Jiang (19452), Xing Liu (221084), Jie Zhang (64655), Jianhua Gan (1493533), Cheng Luo (48047), Hongchuan Liu (2060263), Tengfeng Ni (2745787), Yinqiang Sun (2821539), Lefu Lan (345536), Yingyi Zhang (118046), Fei Ye (339913), Jiahui Li (646449), Ao Zhang (372387), Meining Wang (1763485), Hu Zhou (54222), Cai-Guang Yang (622949)   +15 more
core   +1 more source

Ntag degradation is enhanced by ClpP and ClpS overexpression.

, 2016
Overexpression of a perturbation protein was used to test for degradation effects on Ntag-RFP. Overall degradation is reduced with the target/perturbation plasmid system as indicated by the control conditions (ΔclpP + pTrc versus WT + pTrc).
John W. Bostick (2268028), Andrew M. Gentile (2268031), Keith E. J. Tyo (2268025), Karthik Sekar (2268022)   +3 more
core   +1 more source

ClpP: A distinctive family of cylindrical energy‐dependent serine proteases

FEBS Letters, 2007
Processes maintaining protein homeostasis in the cell are governed by the activities of molecular chaperones that mainly assist in the folding of polypeptide chains and by a large class of proteases that regulate protein levels through degradation. ClpP proteases define a distinctive family of cylindrical, energy‐dependent serine proteases that are ...
Yu, Angela Yeou Hsiung, Houry, Walid A.
openaire   +2 more sources

Molecular insights into the dynamic modulation of bacterial ClpP function and oligomerization by peptidomimetic boronate compounds

Scientific Reports
Bacterial caseinolytic protease P subunit (ClpP) is important and vital for cell survival and infectivity. Recent publications describe and discuss the complex structure–function relationship of ClpP and its processive activity mediated by 14 catalytic ...
Bruno Alves França, Sven Falke, Holger Rohde, Christian Betzel   +3 more
doaj   +1 more source

Spatial optimization of cultivated land protection policy implementation effect in China using a geographically optimal zones-based heterogeneity model

GIScience & Remote Sensing
Cultivated land protection policies (CLPP) are crucial for safeguarding China's food security and promoting sustainable agricultural development; however, their implementation is prone to deviations and divergence from intended objectives.
Yanwei Zhang, Ruixin Chen, Xinhai Lu, Houbao Fan, Li Wang, Bo Xia, Douglas Baker   +6 more
doaj   +1 more source