Results 91 to 100 of about 18,307 (208)

Isolation of highly heat-resistant Listeria monocytogenes variants by use of a kinetic modeling-based sampling scheme [PDF]

, 2011
Stable high-hydrostatic-pressure (HHP)-resistant Listeria monocytogenes LO28 variants were previously isolated and characterized. These HHP variants were also more resistant to heat.
Boeijen, K.H., van, Francke, C., Moezelaar, H.R., Abee, T., Zwietering, M.H.   +4 more
core   +1 more source

Pharmacodynamics of ClpP-Activating Antibiotic Combinations against Gram-Positive Pathogens [PDF]

Antimicrobial Agents and Chemotherapy, 2019
It is often difficult to cure endocarditis, osteomyelitis, and device-associated infections caused by Gram-positive pathogens, despite therapy with clinically appropriate antibiotics. This may be due to antibiotic tolerance or resistance development. Acyldepsipeptides (ADEPs) are a class of bactericidal compounds active against a variety of clinically ...
Nader, Mroue, Anu, Arya, Autumn, Brown Gandt, Cameron, Russell, Angel, Han, Ekaterina, Gavrish, Michael, LaFleur   +6 more
openaire   +2 more sources

TrxR2 Lactylation Facilitates Mitochondrial Protection and Endothelial Ferroptosis Resistance in Diabetic Cardiomyopathy

Advanced Science, Volume 13, Issue 22, 17 April 2026.
TrxR2 deletion in diabetic mice suppresses TUFM‐AMPK‐FUNDC1‐dependent mitophagy in endothelial cells, resulting in SCP2 upregulation and mitochondrial translocation of ACSL4. Mitochondrial ACSL4 promotes mitochondrial eicosanoid biosynthesis and ferroptosis, thereby aggravating cardiac microvascular injury and diabetic cardiomyopathy.
Su Li, Muyin Liu, Chao Chen, Xinyan Li, Xiaopei Yan, Wentao Zhu, Wenyan Qiu, Qiyu Li, Xiangyu Sun, Chao Huang, Ming Yin, Zhangwei Chen, Yao Lu, Junbo Ge, Xiangqing Kong, Juying Qian, Yuqiong Chen   +16 more
wiley   +1 more source

Mutation in human CLPX elevates levels of δ-aminolevulinate synthase and protoporphyrin IX to promote erythropoietic protoporphyria [PDF]

, 2017
Loss-of-function mutations in genes for heme biosynthetic enzymes can give rise to congenital porphyrias, eight forms of which have been described. The genetic penetrance of the porphyrias is clinically variable, underscoring the role of additional ...
Baker, Tania, Bergonia, Hector A., Ducamp, Sarah, Gouya, Laurent, Kafina, Martin D., Kannengiesser, Caroline, Kardon, Julia R., Karim, Zoubida, Manceau, Hana, Nicolas, Gaël, Paw, Barry H., Phillips, John D., Puy, Hervé, van der Vorm, Lisa N., Yien, Yvette Y.   +14 more
core   +3 more sources

The Temporal Expression of Global Regulator Protein CsrA Is Dually Regulated by ClpP During the Biphasic Life Cycle of Legionella pneumophila

Frontiers in Microbiology, 2019
Legionella pneumophila, an environmental bacterium that parasitizes protozoa, is the causative pathogen of Legionnaires' disease. L. pneumophila adopts a distinct biphasic life cycle that allows it to adapt to environmental conditions for survival ...
Zhen-huang Ge, Zhen-huang Ge, Qin-sha Long, Qin-sha Long, Pei-bo Yuan, Pei-bo Yuan, Xin Pan, Dong Shen, Dong Shen, Yong-jun Lu, Yong-jun Lu   +10 more
doaj   +1 more source

Systemic microRNA profiles associated with coronary plaque stability and clinical phenotypes in patients with coronary artery disease

Clinical and Translational Discovery, Volume 6, Issue 2, April 2026.
This study identifies circulating microRNAs associated with plaque destabilization in cardiovascular disease, highlighting their potential as non‐invasive biomarkers and therapeutic targets. Abstract Background The development of coronary artery disease (CAD) and plaque destabilization are caused by endothelial dysfunction, inflammation and hypoxia ...
Souhir Wassaifi, Nadia Rahali, Josef Finsterer, Dhaker Lahidheb, Bertrand Kaeffer, Sinda Zarrouk   +5 more
wiley   +1 more source

The Influence of the Toxin/Antitoxin mazEF on Growth and Survival of Listeria monocytogenes under Stress [PDF]

, 2017
A major factor in the resilience of Listeria monocytogenes is the alternative sigma factor B (σB). Type II Toxin/Antitoxin (TA) systems are also known to have a role in the bacterial stress response upon activation via the ClpP or Lon proteases. Directly
Curtis, Thomas, Gram, Lone, Knudsen, Gitte Maegaard, Takeuchi, Ippei   +3 more
core   +2 more sources

Chloroplast Genomes of Croton alabamensis and Croton bonplandianus (Euphorbiaceae): Comparative Analysis With Related Croton Species

Ecology and Evolution, Volume 16, Issue 4, April 2026.
Croton chloroplast genomes exhibit substantial structural diversity driven mainly by asymmetric inverted repeats (IRs) contraction and expansion, despite highly conserved gene content. IR boundary shifts predominantly involved the LSC region, indicating an LSC‐driven evolutionary pattern. The preliminary phylogenomic analyses confirmed the monophyly of
Rushan Yan, Abdullah, Yujie Zeng, Abdul Sammad, Parviz Heidari, Jingjing Liu, Xiaoxuan Tian   +6 more
wiley   +1 more source

Pelvic floor muscle behavior during Valsalva leak point pressure measurement in males and females affected by stress urinary incontinence. [PDF]

, 2003
PURPOSE: We evaluated pelvic floor muscle (PFM) behavior during Valsalva leak point pressure (VLPP) measurement in males and females affected by stress urinary incontinence and investigated whether VLPP results are influenced by PFM contraction ...
Bini, V, Cucchi, A, Di Stasi, SM, Giannantoni, A, Mearini, E, Porena, M   +5 more
core   +1 more source

Plastid Genome Evolution Across the Roridulaceae–Sarraceniaceae Clade (Ericales) in Relation to Carnivorous Strategies

Ecology and Evolution, Volume 16, Issue 4, April 2026.
The Roridulaceae–Sarraceniaceae clade exhibits strikingly divergent carnivorous strategies, providing a framework to examine how trophic shifts influence plastid genome evolution. Comparative plastome analyses reveal recurrent ndh gene disruption across species, while Roridula gorgonias shows pronounced genomic restructuring, including elevated ...
Shengxin Chang, Peng Wang, Wei Han, Baiyin Yu, Chunxia Li   +4 more
wiley   +1 more source