Results 111 to 120 of about 13,032 (201)

Small Molecule ClpP-Agonists Degrade Mitochondrial Import Machinery, Blocking Entry of Growth-Mediating Protein GRSF1 [PDF]

Small molecule activators of the mitochondrial matrix protease, caseinolytic protease proteolytic subunit (ClpP), have recently garnered attention as a potent and effective modality for the treatment of aggressive, resilient cancers. Dordaviprone (ONC201,
Mistreanu, Andrei
core   +1 more source

ClpP [PDF]

Science-Business eXchange, 2013
openaire   +1 more source

DISSECTING THE ROLE OF CLPP IN MULTIPLE MYELOMA

, 2022
Despite the efficacy of targeted treatments, multiple myeloma (MM) is still incurable, urging to identify novel vulnerabilities to design more effective therapies. Mitochondria are emerging therapeutic targets in oncology for their crucial role not only as cellular powerhouses, but also in signalling, redox homeostasis, initiation of apoptosis ...
openaire   +1 more source

Tripartite evolutionary game and simulation analysis of cultivated land protection policies implementation in China

Cogent Food & Agriculture
China has established the world’s most stringent cultivated land protection policies (CLPP) system. However, the key to policy is its implementation.
Yanwei Zhang, Ruixin Chen, Xinhai Lu, Yucheng Zou   +3 more
doaj   +1 more source

Protein degradation by a component of the chaperonin‐linked protease ClpP

Genes to Cells
AbstractIn cells, proteins are synthesized, function, and degraded (dead). Protein synthesis (spring) is important for the life of proteins. However, how proteins die is equally important for organisms. Proteases are secreted from cells and used as nutrients to break down external proteins. Proteases degrade unwanted and harmful cellular proteins.
Fumihiro Ishikawa, Michio Homma, Genzoh Tanabe, Takayuki Uchihashi   +3 more
openaire   +2 more sources

The Effect of the Lysine Acetylation Modification of ClpP on the Virulence of Vibrio alginolyticus

Acetylation modification has become one of the most popular topics in protein post-translational modification (PTM) research and plays an important role in bacterial virulence.
Yuhang Dong, Jichang Jian, Yingying Jiang, Zhiqing Wei, Weijie Zhang, Na Wang, Huanying Pang, Yingzhu Wei, Xing Xiao, Shi Wang, Xiaoxin Wen   +10 more
core   +1 more source

Trapping and Proteomic Identification of Cellular Substrates of the ClpP Protease in Staphylococcus aureus

, 2016
In the important human pathogen Staphylococcus aureus the cytoplasmic ClpP protease is essential for mounting cellular stress responses and for virulence.
Stephan Michalik (1997962), Anders N. Varming (1997959), Lotte Jelsbak (168171), Hanne Ingmer (94052), Dirk Albrecht (256453), Michael Hecker (51971), Dorte Frees (150622), Julie H. Andersen (1997965), Stefanie Krieger (1997968), Knut Ohlsen (85866), Ulf Gerth (1997974), Jingyuan Feng (1997971)   +11 more
core   +1 more source

Synthesis and Characterization of Small Molecule Dysregulators of the Bacterial ClpP Protease [PDF]

, 2018
Caseinolytic protease P (ClpP) is a protease highly conserved in bacteria and eukaryotes. With an ATPase partner, it functions to maintain protein homeostasis and regulated elimination of folded proteins.
Zhou, Jin Lin
core  

Identification of substrates of the human mitochondrial ClpXP protease and its implications for Perrault syndrome. [PDF]

Nat Commun
Aljghami ME, Morey TM, Mabanglo MF, Meyrick JJ, Thomas HB, Yu J, Tahmasebi A, Lai KL, Raymond BBA, Trost M, Taylor RW, O'Keefe RT, Newman WG, Richter U, Houry WA.   +14 more
europepmc   +1 more source

CLPP loss confers sex-specific protection from renal ischemia reperfusion injury. [PDF]

Redox Biol
Isermann L, Rojas-Morales P, Senft K, Nair N, Baumann L, Croon M, Lauterbach VK, Göbel H, Landini F, Tuma C, Sottorff-Neculhueque I, Thevis M, Ignarski M, Brähler S, Riemer J, Müller RU, Trifunovic A.   +16 more
europepmc   +1 more source