Results 111 to 120 of about 18,307 (208)

Discovery of CLPP-1071 as an Exceptionally Potent and Orally Efficacious Human ClpP Activator with Strong In Vivo Antitumor Activity

Journal of Medicinal Chemistry
Human sapiens caseinolytic protease P (ClpP) is essential for maintaining mitochondrial proteome homeostasis, and its activation is increasingly recognized as a promising cancer therapy strategy. Herein, based on structure-guided drug design, we discovered a series of potent ClpP activators by introducing a methyl group to the imipridone scaffold of ...
Beijing Chen, Mingyang Sun, Chun Zhang, Qi Huang, Dan Teng, Linghao Hu, Huicong Ma, Xinyi Lin, Zan Huang, Renzhao Gui, Xiaobei Hu, Lei Xu, Mingyue Zheng, Yubo Zhou, Jia Li, Mingliang Wang   +15 more
openaire   +2 more sources

Deletion of heat shock protein 60 in adult mouse cardiomyocytes perturbs mitochondrial protein homeostasis and causes heart failure. [PDF]

, 2020
To maintain healthy mitochondrial enzyme content and function, mitochondria possess a complex protein quality control system, which is composed of different endogenous sets of chaperones and proteases.
Chen, Ju, Duan, Yaoyun, Fan, Feifei, Fang, Xi, Huang, Lei, Jia, Nan, Li, Yali, Liu, Jie, Ouyang, Kunfu, Tang, Huayuan, Trexler, Christa, Wang, Gang, Wang, Hong, Yang, Feili   +13 more
core  

Single molecule fluorescence spectroscopy of ClpXP-mediated substrate degradation [PDF]

, 2009
Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2009.Includes bibliographical references (leaves 67-71).Energy-dependent proteases, such as ClpXP, are responsible for the regulated destruction of proteins in ...
Shin, Yongdae
core  

Harmaline to Human Mitochondrial Caseinolytic Serine Protease Activation for Pediatric Diffuse Intrinsic Pontine Glioma Treatment

Pharmaceuticals
Diffuse intrinsic pontine glioma (DIPG), affecting children aged 4–7 years, is a rare, aggressive tumor that originates in the pons and then spreads to nearby tissue.
Morena Miciaccia, Francesca Rizzo, Antonella Centonze, Gianfranco Cavallaro, Marialessandra Contino, Domenico Armenise, Olga Maria Baldelli, Roberta Solidoro, Savina Ferorelli, Pasquale Scarcia, Gennaro Agrimi, Veronica Zingales, Elisa Cimetta, Simone Ronsisvalle, Federica Maria Sipala, Paola Loguercio Polosa, Cosimo Gianluca Fortuna, Maria Grazia Perrone, Antonio Scilimati   +18 more
doaj   +1 more source

Community-level physiological profiling analyses show potential to identify the copiotrophic bacteria present in soil environments.

PLoS ONE, 2017
Community-level physiological profiling (CLPP) analyses from very diverse environments are frequently used with the aim of characterizing the metabolic versatility of whole environmental bacterial communities. While the limitations of the methodology for
Salvador Lladó, Petr Baldrian
doaj   +1 more source

N2 fixing trees (Acacia mangium) introduce in eucalypt plantations modify rapidly the pools of organic P and low-molecular-weight organic acids (LMWOAs) in tropical soils contrasted for their C/P stoichiometry [PDF]

, 2019
In this study, soil organic P (Po) and low-molecular-weight organic acids (LMWOAs) were quantified under different land uses in order to investigate the effect of N2 fixing tree introduction on phosphorus cycle.
Bouillet, Jean-Pierre, Deleporte, Philippe, Gonçalves, José Leonardo M., Laclau, Jean-Paul, Mareschal, Louis, Plassard, Claude, Robin, Agnès, Villeneuve, Manon, Waithaisong, Kittima   +8 more
core  

The Links Between Migration, Poverty and Health: Evidence From Khayelitsha and Mitchell's Plain [PDF]

In the mid-1950s, the City of Cape Town was part of a wider area demarcated as a Coloured Labour Preference Area. The free movement of African people into the city was strictly controlled and the residential areas were segregated along racial lines.
David Ndegwa, Dudley Horner, Faldie Esau
core   +1 more source

Tripartite evolutionary game and simulation analysis of cultivated land protection policies implementation in China

Cogent Food & Agriculture
China has established the world’s most stringent cultivated land protection policies (CLPP) system. However, the key to policy is its implementation.
Yanwei Zhang, Ruixin Chen, Xinhai Lu, Yucheng Zou   +3 more
doaj   +1 more source

The Effect of the Lysine Acetylation Modification of ClpP on the Virulence of Vibrio alginolyticus

Molecules
Acetylation modification has become one of the most popular topics in protein post-translational modification (PTM) research and plays an important role in bacterial virulence.
Shi Wang, Yingying Jiang, Weijie Zhang, Yingzhu Wei, Xing Xiao, Zhiqing Wei, Xiaoxin Wen, Yuhang Dong, Jichang Jian, Na Wang, Huanying Pang   +10 more
doaj   +1 more source

ClpP [PDF]

Science-Business eXchange, 2013
openaire   +1 more source