Results 131 to 140 of about 13,032 (201)

The role of mitochondrial proteases in inflammation and immunity. [PDF]

Front Immunol
Ferreira ARO, Day EA.
europepmc   +1 more source

Targeting ClpP Protease: Emerging Therapeutic Strategies and Small-Molecule Modulators in Drug Discovery. [PDF]

Med Res Rev
Liu L, Yu M, Li X, Xu J, Xie S, Xu S, Yao H.   +6 more
europepmc   +1 more source

TARGETING HUMAN MITOCHONDRIAL ClpP AS A NOVEL THERAPEUTIC APPROACH TO H3K27-ALTERED DIFFUSE MIDLINE GLIOMA

H3K27-altered diffuse midline glioma (DMG) is one of the most aggressive pediatric brain tumors, with a median overall survival of less than 12 months.
Morena Miciaccia, Paola Loguercio Polosa, Maria Grazia Perrone, Cosimo Gianluca Fortuna, Francesco Bruni, Antonio Scilimati, Anselma Liturri, Olga Maria Baldelli, Gianfranco Cavallaro, Savina Ferorelli, Domenico Armenise   +10 more
core  

ONC206 demonstrates potent antitumorigenic activity and is a potential novel therapeutic strategy for high-risk medulloblastoma. [PDF]

Neuro Oncol
Tzaridis T, Liu J, Chien FL, Malhotra A, Zhu D, Gershon I, Zhang H, Velazquez Vega JE, Schniederjan M, Sposito T, Adams PD, Allen JE, Prabhu VV, Wechsler-Reya RJ, MacDonald TJ.   +14 more
europepmc   +1 more source

Repurposing Birabresib to target Gram‑positive bacteria. [PDF]

NPJ Antimicrob Resist
Koly HK, Razzaq R, Hossain T, Butzin NC.
europepmc   +1 more source

Multi-ancestry colocalization approaches. [PDF]

PLoS Genet
Shen C, Dupuis J, Zhang Q.
europepmc   +1 more source

Developing a library of HaloPROTACs targeting the ClpP protease

Proteolysis-targeting chimeras (PROTACs) have received recent attention as a new therapeutic agent that have the potential to have a great impact in drug discovery.
Nani, Alexandra
core  

Daptomycin Overcomes <i>Listeria monocytogenes</i> Persister Cells Through Strain-Dependent Efficacy and clpP-Mediated Stress Response. [PDF]

Infect Drug Resist
Zeinivand Y, Pakzad I, Asadinezhad M, Omidi N, Sadeghi Kalani B.   +4 more
europepmc   +1 more source

Exercise elicits mitonuclear protein imbalance and UPR^mt in the liver of mice with obesity. [PDF]

J Physiol Biochem
Rocha MB, de Araujo IM, Coleta SGDND, Junior SJA, Peres SF, Braga RR, Brícola RS, Carneiro FS, Crisol BM, da Costa RG, Mori MAS, Cintra DE, da Silva ASR, Pauli JR, Ropelle ER.   +14 more
europepmc   +1 more source

ONC201/dordaviprone for H3 K27M-mutant tumors: Discovery, mechanisms, therapeutic potential, and future directions. [PDF]

Genes Dis
Pimentel JM, Zhou JY, Wu GS.
europepmc   +1 more source