Results 151 to 160 of about 10,075 (175)

The development of small-molecule modulators for ClpP protease activity

Molecular BioSystems, 2016
Abstract The global spread of antibiotic resistance among important human pathogens emphasizes the need to find new antibacterial drugs with a novel mode of action. The ClpP protease has been shown to demonstrate its pivotal importance to both the survival and the virulence of pathogenic bacteria during host infection.
Fei, Ye, Jiahui, Li, Cai-Guang, Yang
openaire   +2 more sources

The Role of ClpP Protease in Bacterial Pathogenesis and Human Diseases

ACS Chemical Biology, 2018
In prokaryotic cells and eukaryotic organelles, the ClpP protease plays an important role in proteostasis. The disruption of the ClpP function has been shown to influence the infectivity and virulence of a number of bacterial pathogens. More recently, ClpP has been found to be involved in various forms of carcinomas and in Perrault syndrome, which is ...
Vaibhav Bhandari, Keith S. Wong, Jin Lin Zhou, Mark F. Mabanglo, Robert A. Batey, Walid A. Houry   +5 more
openaire   +2 more sources

Patenting perspective of modulators of ClpP endopeptidase: 2019-present

Expert Opinion on Therapeutic Patents
ClpP is a highly conserved serine protease that plays a crucial role in maintaining protein homeostasis in both bacterial cells and human mitochondria. Several studies have demonstrated the potential of ClpP as a drug target, with ClpP modulators, including both inhibitors and activators, showing promise in treating a range of conditions such as drug ...
Zhenyu, Wang, Liqing, He, Ziheng, Fan, Youfu, Luo   +3 more
openaire   +2 more sources

ClpP Peptidase as a Plausible Target for the Discovery of Novel Antibiotics

Current Drug Targets
Abstract: Antimicrobial resistance (AMR) to currently available antibiotics/drugs is a global threat. It is desirable to develop new drugs that work through a novel target(s) to avoid drug resistance. This review discusses the potential of the caseinolytic protease P (ClpP) peptidase complex as a novel target for finding novel antibiotics, emphasising
Smriti Bhardwaj, Kuldeep K. Roy
openaire   +2 more sources

Potent ClpP agonists with anticancer properties bind with improved structural complementarity and alter the mitochondrial N-terminome

Structure, 2023
Mark F Mabanglo, Elisa Leung, Walid A Houry   +2 more
exaly  

Aberrant human ClpP activation disturbs mitochondrial proteome homeostasis to suppress pancreatic ductal adenocarcinoma

Cell Chemical Biology, 2022
Xiongxiong Lu, Cai-Guang Yang
exaly  

Assessing CLPPs using MicroResp™

Journal of Soils and Sediments, 2007
Stephen J. Chapman, Colin D. Campbell, Rebekka R. E. Artz   +2 more
openaire   +1 more source

Assessment of the structure-activity relationship and antileukemic activity of diacylpyramide compounds as human ClpP agonists

European Journal of Medicinal Chemistry, 2023
Pengyu Wang, Yihui Pan, Jianhua Gan
exaly  

ClpP: a new Achilles' heel in myeloma

Blood
Antonio Sacco, Aldo M. Roccaro
openaire   +2 more sources

Mitochondrial ClpP-Mediated Proteolysis Induces Selective Cancer Cell Lethality

Cancer Cell, 2019
Jo Ishizawa, Ondřej Halgas, Ran Zhao
exaly