Results 141 to 150 of about 10,075 (175)
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Selective Activation of Human Caseinolytic Protease P (ClpP)
Angewandte Chemie - International Edition, 2018AbstractCaseinolytic protease P (ClpP) is the proteolytic component of the ClpXP protein degradation complex. Eukaryotic ClpP was recently found to act within the mitochondria‐specific unfolded protein response (UPRmt). However, its detailed function and dedicated regulation remain largely unexplored.
Matthias Stahl +2 more
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The Mechanism of Caseinolytic Protease (ClpP) Inhibition
Angewandte Chemie - International Edition, 2013Malte Gersch +2 more
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Structural insights into the evolutionary simplification of human ClpP activators
Structure, 2023In this issue of Structure, Mabanglo et al. characterize five ClpP agonists termed TRs. The co-crystal structures reveal more robust shape and charge complementarities than the anti-cancer agent ONC201. These novel compounds are of potential therapeutic interest because they enhance ClpP proteolytic activity and have an inhibitory effect on tumor cell ...
Lin-Lin, Zhou, Cai-Guang, Yang
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The activated ClpP peptidase forcefully grips a protein substrate
Biophysical Journal, 2022ATPases associated with diverse cellular activities (AAA+) proteases power the maintenance of protein homeostasis by coupling ATP hydrolysis to mechanical protein unfolding, translocation, and ultimately degradation. Although ATPase activity drives a large portion of the mechanical work these molecular machines perform, how the peptidase contributes to
Steven D, Walker, Adrian O, Olivares
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The regulation of Porphyromonas gingivalis biofilm formation by ClpP
Biochemical and Biophysical Research Communications, 2019Porphyromonas gingivalis is one of the most commonly detected pathogens in periodontal disease and root canal infections. Its viability and pathogenicity are greatly increased in plaque biofilms. Some caseinolytic proteases (Clp) reportedly regulate biofilm formation by various pathogenic bacteria, including P. gingivalis.
Lu, He +3 more
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The Role of ClpP in Protein Expression of Streptococcus pneumoniae
Current Microbiology, 2011Previous reports suggest that ClpP proteolytic activity is important not only for cell physiology but also for regulation of virulence properties of Streptococcus pneumoniae (S. pneumoniae). In order to get a more comprehensive picture of the role of ClpP protease on protein expression in S. pneumoniae D39 and how it relates to physiology and virulence,
Qun, Zhang +6 more
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The Structural Basis for the Activation and Peptide Recognition of Bacterial ClpP
Journal of Molecular Biology, 2008ClpP and its ATPase compartment, ClpX or ClpA, remove misfolded proteins in cells and are of utmost importance in protein quality control. The ring hexamers of ClpA or ClpX recognize, unfold, and translocate target substrates into the degradation chamber of the double-ring tetradecamer of ClpP.
Dong Young, Kim, Kyeong Kyu, Kim
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ClpP: A structurally dynamic protease regulated by AAA+ proteins
Journal of Structural Biology, 2012Proteolysis is an important process for many aspects of bacterial physiology. Clp proteases carry out a large proportion of protein degradation in bacteria. These enzymes assemble in complexes that combine the protease ClpP and the unfoldase, ClpA or ClpX.
John A, Alexopoulos +2 more
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Characterization of mouse Clpp protease cDNA, gene, and protein
Mammalian Genome, 2000Mutations that cause accumulation or rapid degradation owing to protein misfolding are a frequent cause of inherited disease in humans. In Escherichia coli, Clpp protease is one of the components of the protein quality control system that handles misfolded proteins.
Andresen, B S +7 more
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Role of ClpP in biofilm formation and virulence of Staphylococcus epidermidis
Microbes and Infection, 2007Infections caused by the leading nosocomial pathogen Staphylococcus epidermidis are characterized by biofilm formation on implanted medical devices. However, the molecular basis of biofilm formation and its regulation are not completely understood.
Chongzhen, Wang +6 more
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