Frontiers in Cell and Developmental Biology, 2021 Several studies reported that mitochondrial stress induces cytosolic proteostasis. How mitochondrial stress activates proteostasis in the cytosol remains unclear.
Doris Germain, Mrittika Chattopadhyay
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Exercise alters the mitochondrial proteostasis and induces the mitonuclear imbalance and UPRmt in the hypothalamus of mice [PDF]
Scientific Reports, 2021 The maintenance of mitochondrial activity in hypothalamic neurons is determinant to the control of energy homeostasis in mammals. Disturbs in the mitochondrial proteostasis can trigger the mitonuclear imbalance and mitochondrial unfolded protein response
Renata R. Braga +11 more
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CLPX acquires an iron-sulfur cluster to sustain mitochondrial proteostasis in cancer cells [PDF]
Nature CommunicationsMitochondrial proteostasis-maintaining mechanisms are crucial for protecting cells from the toxicity of misfolded protein accumulation. Although excessive stress is known to inactivate these mechanisms and thereby induce mitophagy in cancer cells, the ...
Chengquan Huang +9 more
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Caloric Restriction Induces MicroRNAs to Improve Mitochondrial Proteostasis [PDF]
iScience, 2019 Summary: Both caloric restriction (CR) and mitochondrial proteostasis are linked to longevity, but how CR maintains mitochondrial proteostasis in mammals remains elusive. MicroRNAs (miRNAs) are well known for gene silencing in cytoplasm and have recently
Ran Zhang +17 more
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Molecular Perspectives of Mitochondrial Adaptations and Their Role in Cardiac Proteostasis
Frontiers in Physiology, 2020 Mitochondria are the key to properly functioning energy generation in the metabolically demanding cardiomyocytes and thus essential to healthy heart contractility on a beat-to-beat basis.
Chowdhury S Abdullah +2 more
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Imbalanced Skeletal Muscle Mitochondrial Proteostasis Causes Bone Loss [PDF]
ResearchAlthough microgravity has been implicated in osteoporosis, the precise molecular mechanism remains elusive. Here, we found that microgravity might induce mitochondrial protein buildup in skeletal muscle, alongside reduced levels of LONP1 protein.
Zhen Jin +14 more
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HAX1-dependent control of mitochondrial proteostasis governs neutrophil granulocyte differentiation [PDF]
The Journal of Clinical Investigation, 2022 The relevance of molecular mechanisms governing mitochondrial proteostasis to the differentiation and function of hematopoietic and immune cells is largely elusive. Through dissection of the network of proteins related to HCLS1-associated protein X-1, we
Yanxin Fan +16 more
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Unraveling sex differences in age-related hippocampal decline: differential mitochondrial dysfunction, Lonp1-dependent mitochondrial proteostasis and mtROS production in aged C57BL/6 mice [PDF]
Cell Death and DiseaseAging is a progressive process characterized by cellular and molecular damage leading to mitochondrial dysfunction and cognitive decline. Mitochondrial dysfunction is a critical factor in memory impairment in aging and neurodegenerative diseases.
Karina A. Cicali +11 more
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Cell Reports, 2017 Summary: In Caenorhabditis elegans, the programmed repression of the heat shock response (HSR) accompanies the transition to reproductive maturity, leaving cells vulnerable to environmental stress and protein aggregation with age. To identify the factors
Johnathan Labbadia +2 more
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LONP1 and ClpP cooperatively regulate mitochondrial proteostasis for cancer cell survival [PDF]
Oncogenesis, 2021 Mitochondrial proteases are key components in mitochondrial stress responses that maintain proteostasis and mitochondrial integrity in harsh environmental conditions, which leads to the acquisition of aggressive phenotypes, including chemoresistance and ...
Yu Geon Lee +8 more
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