Results 21 to 30 of about 426,171 (247)

Mitochondrial Proteostasis and Hypoxic Injury

, 2018
Despite considerable effort to develop neuro and cardioprotective drugs there remains no treatment other than restoration of blood flow to treat hypoxic/ischemic injuries such as strokes and myocardial infarctions.
Kaufman, Daniel Martin
core   +3 more sources

Anakinra restores cellular proteostasis by coupling mitochondrial redox balance to autophagy [PDF]

The Journal of Clinical Investigation, 2022
Autophagy selectively degrades aggregation-prone misfolded proteins caused by defective cellular proteostasis. However, the complexity of autophagy may prevent the full appreciation of how its modulation could be used as a therapeutic strategy in disease
Frank L. van de Veerdonk, Giorgia Renga, Marilena Pariano, Marina M. Bellet, Giuseppe Servillo, Francesca Fallarino, Antonella De Luca, Rossana G. Iannitti, Danilo Piobbico, Marco Gargaro, Giorgia Manni, Fiorella D’Onofrio, Claudia Stincardini, Luigi Sforna, Monica Borghi, Marilena Castelli, Stefania Pieroni, Vasileios Oikonomou, Valeria R. Villella, Matteo Puccetti, Stefano Giovagnoli, Roberta Galarini, Carolina Barola, Luigi Maiuri, Maria Agnese Della Fazia, Barbara Cellini, Vincenzo Nicola Talesa, Charles A. Dinarello, Claudio Costantini, Luigina Romani   +29 more
doaj   +2 more sources

Temporal landscape of mitochondrial proteostasis governed by the UPRmt

, 2023
<p>Breakdown of mitochondrial proteostasis activates quality control pathways including the mitochondrial unfolded protein response (UPR^mt) and PINK1/Parkin mitophagy.
Lindblom, Runa, Lazarou, Michael, Skulsuppaisarn, Marvin, Khuu, Grace, Lam, Wai Kit, Schittenhelm, Ralf, Filipovska, Aleksandra, Rudler, Danielle, Uoselis, Louise, Küng, Catharina, Nguyen, Thanh   +10 more
core   +3 more sources

Regulation of mitochondrial proteostasis by the proton gradient. [PDF]

EMBO J, 2022
Mitochondria adapt to different energetic demands reshaping their proteome. Mitochondrial proteases are emerging as key regulators of these adaptive processes. Here, we use a multiproteomic approach to demonstrate the regulation of the m-AAA protease AFG3L2 by the mitochondrial proton gradient, coupling mitochondrial protein turnover to the energetic ...
Patron M, Tarasenko D, Nolte H, Kroczek L, Ghosh M, Ohba Y, Lasarzewski Y, Ahmadi ZA, Cabrera-Orefice A, Eyiama A, Kellermann T, Rugarli EI, Brandt U, Meinecke M, Langer T.   +14 more
europepmc   +9 more sources

Failed mitochondrial import and impaired proteostasis trigger SUMOylation of mitochondrial proteins [PDF]

Journal of Biological Chemistry, 2018
Modification by the ubiquitin-like protein SUMO affects hundreds of cellular substrate proteins and regulates a wide variety of physiological processes.
Pfander, B., Florian Paasch, Fabian den Brave, den Brave, F., Psakhye, I., Paasch, F., Jentsch, S., Boris Pfander, Ivan Psakhye, Stefan Jentsch   +9 more
core   +5 more sources

Inhibition of stress-inducible HSP70 impairs mitochondrial proteostasis and function [PDF]

Oncotarget, 2017
Protein quality control is an important component of survival for all cells. The use of proteasome inhibitors for cancer therapy derives from the fact that tumor cells generally exhibit greater levels of proteotoxic stress than do normal cells, and thus ...
Gao Zhang, George, Donna L., Thibaut Barnoud, Julia I-Ju Leu, Zhang, Gao, Wei, Zhi, Tian Tian, Barnoud, Thibaut, Tian, Tian, Zhi Wei, Maureen E. Murphy, Donna L. George, Leu, Julia I.Ju, Meenhard Herlyn, Murphy, Maureen E., Herlyn, Meenhard   +15 more
core   +4 more sources

Mutant CHCHD10 disrupts cytochrome c oxidation and activates mitochondrial retrograde signaling

EMBO Molecular Medicine
Mutations in CHCHD10, a mitochondrial intermembrane space (IMS) protein implicated in proteostasis and cristae maintenance, cause mitochondrial disease. Knock-in mice modeling the human CHCHD10 S59L variant associated with ALS–FTD develop a mitochondrial
Márcio Augusto Campos-Ribeiro, Erminia Donnarumma, Hendrik Nolte, Paul Cobine, Elodie Vimont, Dusanka Milenkovic, Juan Diego Hernandez-Camacho, Francina Langa-Vives, Etienne Kornobis, Esthel Pénard, Sonny Yde, Thomas Langer, Véronique Paquis-Flucklinger, Timothy Wai   +13 more
doaj   +2 more sources

Mitochondrial quality control in cardiac diseases.

Frontiers in Physiology, 2016
Disruption of mitochondrial homeostasis is a hallmark of cardiac diseases. Therefore, maintenance of mitochondrial integrity through different surveillance mechanisms is critical for cardiomyocyte survival.
Juliane Campos, Luiz Bozi, Luiz Bechara, Vanessa Lima, Julio Cesar Batista Ferreira   +4 more
doaj   +2 more sources

Temporal landscape of mitochondrial proteostasis governed by the UPR^mt. [PDF]

Sci Adv, 2023
Breakdown of mitochondrial proteostasis activates quality control pathways including the mitochondrial unfolded protein response (UPR mt ) and PINK1/Parkin mitophagy. However, beyond the up-regulation of chaperones and proteases, we have a limited understanding of how the UPR
Uoselis L, Lindblom R, Lam WK, Küng CJ, Skulsuppaisarn M, Khuu G, Nguyen TN, Rudler DL, Filipovska A, Schittenhelm RB, Lazarou M.   +10 more
europepmc   +3 more sources

Editorial: Mitophagy and mitochondrial proteostasis in cardiovascular diseases. [PDF]

Front Cardiovasc Med, 2022
Dymkowska D, Parra V.
europepmc   +4 more sources