Aerobic Exercise Delays Alzheimer’s Disease by Regulating Mitochondrial Proteostasis in the Cerebral Cortex and Hippocampus [PDF]
Life, 2023 Guoliang Fang, Kaiyin Cui
exaly +2 more sources
Minor Phytocannabinoids as Candidate Multi-Target Modulators of Endoplasmic Reticulum Stress-Linked Proteostasis Failure in Alzheimer’s Disease: A Mechanistic Review [PDF]
BiomoleculesAlzheimer’s disease (AD) involves pathological processes that may limit single-target therapeutic strategies. Endoplasmic reticulum (ER) stress and unfolded protein response (UPR) dysregulation may contribute to proteostasis failure. This review examines
Hyewon Lee +2 more
doaj +2 more sources
SBK2 Links Cardiac Stress Signaling to Mitochondrial Proteostasis. [PDF]
Circ ResCoughlin TM, Makarewich CA.
europepmc +3 more sources
Role of IRE1α in podocyte proteostasis and mitochondrial health [PDF]
Cell Death Discovery, 2020 Abstract Glomerular epithelial cell (GEC)/podocyte proteostasis is dysregulated in glomerular diseases. The unfolded protein response (UPR) is an adaptive pathway in the endoplasmic reticulum (ER) that upregulates proteostasis resources.
José R. Navarro-Betancourt +5 more
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MitoCPR: Meticulous Monitoring of Mitochondrial Proteostasis [PDF]
Molecular Cell, 2018 Mitochondrial protein import stress compromises functioning of the organelles, due to inadequate supply of inner mitochondrial proteins. Weidberg and Amon (2018) describe a new monitoring pathway in budding yeast, which restores mitochondrial function following the clearing of accumulated unfolded pre-transported mitochondrial proteins, by devising a ...
Desai, Radha, Campanella, Michelangelo
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Mitochondrial Proteostasis in the Control of Aging and Longevity [PDF]
Cell Metabolism, 2014 Mitochondria play a central role in the aging process. Studies in model organisms have started to integrate mitochondrial effects on aging with the maintenance of protein homeostasis. These findings center on the mitochondrial unfolded protein response (UPR(mt)), which has been implicated in lifespan extension in worms, flies, and mice, suggesting a ...
Jensen, Martin Borch, Jasper, Heinrich
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BMC Biology, 2020 Background The mitochondrial intermembrane space (IMS) is home to proteins fulfilling numerous essential cellular processes, particularly in metabolism and mitochondrial function.
Lena Maria Murschall +7 more
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Targeting mitochondrial function and proteostasis to mitigate dynapenia [PDF]
European Journal of Applied Physiology, 2017 Traditionally, interventions to treat skeletal muscle aging have largely targeted sarcopenia-the age-related loss of skeletal muscle mass. Dynapenia refers to the age-related loss in skeletal muscle function due to factors outside of muscle mass, which helps to inform treatment strategies for aging skeletal muscle.
Robert V, Musci +2 more
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Quality control at the powerhouse: mitochondrial proteostasis dysfunction and disease. [PDF]
Biochem Soc TransIntrinsic protein quality control (QC) mechanisms are essential in maintaining mitochondrial health and function. These sophisticated molecular machineries govern protein trafficking and import, processing, folding, maturation and degradation, ensuring the organelle’s health.
Baker MJ, Yek KQ, Stojanovski D.
europepmc +4 more sources
Protein Import Assay into Mitochondria Isolated from Human Cells
Bio-Protocol, 2021 Mitochondria are essential organelles containing approximately 1,500 proteins. Only approximately 1% of these proteins are synthesized inside mitochondria, whereas the remaining 99% are synthesized as precursors on cytosolic ribosomes and imported into ...
Lena Murschall +4 more
doaj +1 more source