Cell Reports, 2018 Summary: The mitochondrial unfolded protein response (UPRmt) is critical for maintaining mitochondrial protein homeostasis in response to mitochondrial stress, but early steps in UPRmt activation are not well understood.
Sungjin Kim, Derek Sieburth
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Glutamine supplementation reverses manganese neurotoxicity by eliciting the mitochondrial unfolded protein response [PDF]
iScience, 2023 Summary: Excessive exposure to manganese (Mn) can cause neurological abnormalities, but the mechanism of Mn neurotoxicity remains unclear. Previous studies have shown that abnormal mitochondrial metabolism is a crucial mechanism underlying Mn ...
Shixuan Zhang +5 more
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Mitochondrial unfolded protein response (UPRmt): what we know thus far [PDF]
Frontiers in Cell and Developmental BiologyMitochondria are key organelles for the optimal function of the cell. Among their many functions, they maintain protein homeostasis through their own proteostatic machinery, which involves proteases and chaperones that regulate protein import and folding
Angie K. Torres +4 more
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Mitochondrial Quality Control via Mitochondrial Unfolded Protein Response (mtUPR) in Ageing and Neurodegenerative Diseases [PDF]
Biomolecules, 2023 Mitochondria play a key role in cellular functions, including energy production and oxidative stress regulation. For this reason, maintaining mitochondrial homeostasis and proteostasis (homeostasis of the proteome) is essential for cellular health ...
Paula Cilleros-Holgado +11 more
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Unraveling the role of mitochondrial unfolded protein response in colorectal cancer [PDF]
Biochemistry and Biophysics ReportsColorectal cancer (CRC) ranks among the most prevalent malignancies globally and is the third leading cause of cancer - related deaths. Despite advancements in diagnosis and treatment, prognosis for CRC patients, especially those with advanced or ...
Jihao Shi +3 more
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Proteasome activity contributes to pro-survival response upon mild mitochondrial stress in Caenorhabditis elegans. [PDF]
PLoS Biology, 2021 Defects in mitochondrial function activate compensatory responses in the cell. Mitochondrial stress that is caused by unfolded proteins inside the organelle induces a transcriptional response (termed the "mitochondrial unfolded protein response" [UPRmt])
Maria Sladowska +8 more
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Identification of Mitochondrial Unfolded Protein Response-Related Genes and Diagnostic Biomarkers in Atherosclerosis by Integrative Multidimensional Analysis and Experimental Validation [PDF]
Journal of Inflammation ResearchShuguang Wu,1,2 Yanhong Liu,3 Yu Li,2 Junyu Lai,3 Qiang Wan,3 Jianguang Wu,2,3 Yirong Ma2 1Jiangxi Province Hospital of Integrated Chinese & Western Medicine, Nanchang, People’s Republic of ...
Wu S +6 more
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The mitochondrial unfolded protein response regulates hippocampal neural stem cell aging. [PDF]
Cell Metab, 2023 Wang CL +11 more
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PKR activation in mitochondrial unfolded protein response-mitochondrial dsRNA might do the trick [PDF]
Frontiers in Cell and Developmental Biology, 2023 Eva Rath
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Activation of mitochondrial unfolded protein response protects against multiple exogenous stressors
Life Science Alliance, 2021 This work highlights the importance of the mitochondrial unfolded protein response in allowing organisms to survive external stressors through up-regulation of other stress response pathways.
Sonja K Soo +4 more
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