Results 21 to 30 of about 8,821,559 (269)
Insight into the mitochondrial unfolded protein response and cancer: opportunities and challenges [PDF]
Cell & Bioscience, 2022 The mitochondrial unfolded protein response (UPRmt) is an evolutionarily conserved protective transcriptional response that maintains mitochondrial proteostasis by inducing the expression of mitochondrial chaperones and proteases in response to various ...
Ge Wang, Yumei Fan, Pengxiu Cao, Ke Tan
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Activation of the Mitochondrial Unfolded Protein Response: A New Therapeutic Target?
Biomedicines, 2022 Mitochondrial dysfunction is a key hub that is common to many diseases. Mitochondria’s role in energy production, calcium homeostasis, and ROS balance makes them essential for cell survival and fitness. However, there are no effective treatments for most
Juan M. Suárez-Rivero +11 more
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Estrogen receptor mediates a distinct mitochondrial unfolded protein response [PDF]
Journal of Cell Science, 2011 Unfolded protein responses (UPRs) of the endoplasmic reticulum and mitochondrial matrix have been described. Here, we show that the accumulation of proteins in the inter-membrane space (IMS) of mitochondria in the breast cancer cell line MCF-7 activates ...
Doris Germain, Luena Papa
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Mitochondrial Activity and Unfolded Protein Response are Required for Neutrophil Differentiation [PDF]
Cellular Physiology and Biochemistry, 2018 Background/Aims: Endoplasmic reticulum (ER) stress and unfolded protein response (UPR) are involved in hematopoietic differentiation. However, the mechanistic linkage between ER stress/UPR and hematopoietic differentiation remains unclear.
Ayako Tanimura +5 more
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HSF1 is required for induction of mitochondrial chaperones during the mitochondrial unfolded protein response [PDF]
FEBS Open Bio, 2020 The mitochondrial unfolded protein response (UPRmt) is characterized by the transcriptional induction of mitochondrial chaperone and protease genes in response to impaired mitochondrial proteostasis and is regulated by ATF5 and CHOP in mammalian cells ...
Arpit Katiyar +7 more
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eLife, 2021 Mitochondrial activity determines aging rate and the onset of chronic diseases. The mitochondrial permeability transition pore (mPTP) is a pathological pore in the inner mitochondrial membrane thought to be composed of the F-ATP synthase (complex V ...
Suzanne Angeli +7 more
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Germline regulation of the intestinal mitochondrial unfolded protein response. [PDF]
GeroscienceAbstract The disposable soma theory posits that there is a trade-off between reproduction and somatic maintenance. In support of this theory, we previously identified that pharmacological inhibition of the germline has widespread protective cell non-autonomous effects on cellular protein homeostasis in the model ...
Foulger AC +6 more
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SirT3 Regulates the Mitochondrial Unfolded Protein Response [PDF]
Molecular and Cellular Biology, 2014 The mitochondria of cancer cells are characterized by elevated oxidative stress caused by reactive oxygen species (ROS). Such an elevation in ROS levels contributes to mitochondrial reprogramming and malignant transformation. However, high levels of ROS can cause irreversible damage to proteins, leading to their misfolding, mitochondrial stress, and ...
Luena, Papa, Doris, Germain
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Frontiers in Molecular Neuroscience, 2022 Aging and age-related neurodegeneration are both associated with the accumulation of unfolded and abnormally folded proteins, highlighting the importance of protein homeostasis (termed proteostasis) in maintaining organismal health.
Andrew P. K. Wodrich +7 more
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The mitochondrial unfolded protein response in mammalian physiology [PDF]
Mammalian Genome, 2014 Mitochondria, the main site of cellular energy harvesting, are derived from proteobacteria that evolved within our cells in endosymbiosis. Mitochondria retained vestiges of their proteobacterial genome, the circular mitochondrial DNA, which encodes 13 subunits of the oxidative phosphorylation multiprotein complexes in the electron transport chain (ETC),
Mottis, Adrienne +2 more
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