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Signaling and Regulation of the Mitochondrial Unfolded Protein Response [PDF]

Cold Spring Harbor Perspectives in Biology, 2019
The mitochondrial proteome encompasses more than a thousand proteins, which are encoded by the mitochondrial and nuclear genomes. Mitochondrial biogenesis and network health relies on maintenance of protein import pathways and the protein-folding environment.
Nandhitha Uma, Naresh, Cole M, Haynes
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Open questions on the mitochondrial unfolded protein response [PDF]

The FEBS Journal, 2020
Mitochondrial protein homeostasis is crucial for cellular health, and perturbations have been linked to a plethora of human diseases. Proteostasis is maintained mainly by a network of mitochondrial chaperones and proteases, that assist in protein folding and degrade nonfunctional or superfluous proteins.
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mtDNA, Metastasis, and the Mitochondrial Unfolded Protein Response (UPRmt) [PDF]

Frontiers in Cell and Developmental Biology, 2017
While several studies have confirmed a link between mitochondrial DNA (mtDNA) mutations and cancer cell metastasis, much debate remains regarding the nature of the alternations in mtDNA leading to this effect. Meanwhile, the mitochondrial unfolded protein response (UPRmt) has gained much attention in recent years, with most studies of this pathway ...
Kenny, Timothy C., Germain, Doris
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Cardioprotection by the mitochondrial unfolded protein response requires ATF5 [PDF]

American Journal of Physiology-Heart and Circulatory Physiology, 2019
The mitochondrial unfolded protein response (UPR mt ) is a cytoprotective signaling pathway triggered by mitochondrial dysfunction. UPR mt activation upregulates chaperones, proteases, antioxidants, and glycolysis at the gene level to restore ...
Yves T. Wang, Yunki Lim, Matthew N. McCall, Kai-Ting Huang, Cole M. Haynes, Keith Nehrke, Paul S. Brookes   +6 more
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Surveillance-activated defenses block the ROS-induced mitochondrial unfolded protein response. [PDF]

PLoS Genetics, 2013
Disturbance of cellular functions results in the activation of stress-signaling pathways that aim at restoring homeostasis. We performed a genome-wide screen to identify components of the signal transduction of the mitochondrial unfolded protein response
Eva D Runkel, Shu Liu, Ralf Baumeister, Ekkehard Schulze   +3 more
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Rosmarinic Acid Inhibits Mitochondrial Damage by Alleviating Unfolded Protein Response

Frontiers in Pharmacology, 2022
Mitochondria are essential organelles that perform important roles in cell biologies such as ATP synthesis, metabolic regulation, immunomodulatory, and apoptosis.
Guoen Cai, Fabin Lin, Fabin Lin, Dihang Wu, Dihang Wu, Chenxin Lin, Chenxin Lin, Huiyun Chen, Yicong Wei, Huidan Weng, Zhiting Chen, Minxia Wu, En Huang, Zucheng Ye, Qinyong Ye   +14 more
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UPRmt scales mitochondrial network expansion with protein synthesis via mitochondrial import in Caenorhabditis elegans

Nature Communications, 2021
The mitochondrial network expands to accommodate cell growth, but how scaling occurs is unclear. Here, the authors show in C. elegans that ATFS-1 mitochondrial import is reduced when mitochondrial proteins are highly expressed, activating the unfolded ...
Tomer Shpilka, YunGuang Du, Qiyuan Yang, Andrew Melber, Nandhitha Uma Naresh, Joshua Lavelle, Sookyung Kim, Pengpeng Liu, Hilla Weidberg, Rui Li, Jun Yu, Lihua Julie Zhu, Lara Strittmatter, Cole M. Haynes   +13 more
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Signaling the mitochondrial unfolded protein response

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2013
Mitochondria are compartmentalized organelles essential for numerous cellular functions including ATP generation, iron-sulfur cluster biogenesis, nucleotide and amino acid metabolism as well as apoptosis. To promote biogenesis and proper function, mitochondria have a dedicated repertoire of molecular chaperones to facilitate protein folding and quality
Pellegrino, Mark W., Nargund, Amrita M., Haynes, Cole M.   +2 more
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Decreased Mitochondrial Membrane Potential Activates the Mitochondrial Unfolded Protein Response

microPublication biology, 2021
Mitochondria are organelles that make ATP by generating a proton gradient across the inner membrane through the action of the electron transport chain (ETC). The gradient is composed of a membrane potential (Δψm) and a concentration gradient (ΔpH). In addition to energy production, mitochondria are recognized as signaling organelles (Chandel 2015), and
Berry, Brandon J., Nieves, Tyrone O., Wojtovich, Andrew P.   +2 more
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Proteomic Analysis of the Mitochondrial Responses in P19 Embryonic Stem Cells Exposed to Florfenicol

Toxics, 2023
Florfenicol (FLO) has been shown to elicit diverse toxic effects in plants, insects, and mammals. Previously, our investigations revealed that FLO induced abnormal cardiac development and early embryonic mortality in chicken embryos.
Zhihua Dong, Xueke Hou, Xueying Wang, Zihui Shen, Huiqing Pang, Lingli Chen, Zhihong Yin, Fei Ren, Weiguo Li, Yaming Ge, Hongmei Ning, Dongfang Hu   +11 more
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