Results 51 to 60 of about 8,821,559 (269)
Metabolic consequences of neuronal mitochondrial fission ablation [PDF]
, 2016 Dynamin-related protein 1 (Drp1), the main mammalian mediator of mitochondrial fission, has an especially important role in neuronal development, such that its deletion gives rise to pre- or perinatal lethality.
Restelli, Lisa Michelle
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Histone deacetylase HDA-1 modulates mitochondrial stress response and longevity
Nature Communications, 2020 Caenorhabditis elegans responds to mitochondrial stress by activating the mitochondrial unfolded protein response (UPRmt). Here the authors show that HDA-1, the C.
Li-Wa Shao +7 more
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Sensing the Stress: A Role for the UPRmt and UPRam in the Quality Control of Mitochondria
Frontiers in Cell and Developmental Biology, 2018 Mitochondria exist as compartmentalized units, surrounded by a selectively permeable double membrane. Within is contained the mitochondrial genome and protein synthesis machinery, required for the synthesis of OXPHOS components and ultimately, ATP ...
Sylvie Callegari, Sven Dennerlein
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Mitochondrial unfolded protein response: A novel pathway in metabolism and immunity
Pharmacological Research, 2021 Mitochondrial unfolded protein response (mitoUPR) is a mitochondria stress response to maintain mitochondrial proteostasis during stress. Increasing evidence suggests that mitoUPR participates in diverse physiological processes especially metabolism and immunity.
Li Zhu, Xuling Luo, Nian Fu, Linxi Chen
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Kaohsiung Journal of Medical Sciences, 2020 Accumulation of oxidative proteins within mitochondria leads to loss of mitochondrial function, which may lead to age‐related degenerative diseases. Mitochondrial antioxidant defense capacity reflects the expression of mitochondrial unfolded protein ...
Tzu‐Ying Lee +5 more
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Protein translocation across mitochondrial membranes [PDF]
, 1992 Protein translocation across biological membranes is of fundamental importance for the biogenesis of organelles and in protein secretion. We will give an overview of the recent achievements in the understanding of protein translocation across ...
Walter Neupert +3 more
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Inhibition of mitochondrial genome expression triggers the activation of CHOP-10 by a cell signaling dependent on the integrated stress response but not the mitochondrial unfolded protein response [PDF]
, 2015 Mitochondria-to-nucleus communication, known as retrograde signaling, is important to adjust the nuclear gene expression in response to organelle dysfunction.
Arnould, Thierry +3 more
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Mitochondrial stress signaling in longevity: A new role for mitochondrial function in aging
Redox Biology, 2014 Mitochondria are principal regulators of cellular function and metabolism through production of ATP for energy homeostasis, maintenance of calcium homeostasis, regulation of apoptosis and fatty acid oxidation to provide acetyl CoA for fueling the ...
Shauna Hill, Holly Van Remmen
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Journal of Hematology & Oncology, 2022 Mitochondria are essential for tumor growth and progression. However, the heavy demand for mitochondrial activity in cancer leads to increased production of mitochondrial reactive oxygen species (mtROS), accumulation of mutations in mitochondrial DNA ...
Joseph R. Inigo, Dhyan Chandra
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Mitochondrial Metabolic Signatures in Hepatocellular Carcinoma
Cells, 2021 Hepatocellular carcinoma (HCC) is one of the leading causes of cancer death worldwide. HCC progression and metastasis are closely related to altered mitochondrial metabolism, including mitochondrial stress responses, metabolic reprogramming, and ...
Ho-Yeop Lee +3 more
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