Results 71 to 80 of about 8,821,559 (269)

Roles of mitochondrial unfolded protein response in mammalian stem cells

World Journal of Stem Cells, 2021
The mitochondrial unfolded protein response (UPRmt) is an evolutionarily conserved adaptive mechanism for improving cell survival under mitochondrial stress. Under physiological and pathological conditions, the UPRmt is the key to maintaining intracellular homeostasis and proteostasis. Important roles of the UPRmt have been demonstrated in a variety of
Gu, Li-Fang, Chen, Jia-Qi, Lin, Qing-Yin, Yang, Yan-Zhou   +3 more
openaire   +2 more sources

Rab1A Promotes Hepatic Steatosis by Suppressing Mitophagy via the Raf‐1/ERK1/2/PINK1 Signaling Axis

Advanced Science, EarlyView.
Why does fat accumulate in the liver? Our study reveals Rab1A as the molecular switch that silences the cell's mitochondrial cleanup crew. Turning Rab1A off reactivates mitophagy, clears excess fat, and reverses fatty liver disease in mice—offering a promising new therapeutic target for MASLD, a growing global health challenge.
Li Zhang, Jianhua Li, Huilu Zhang, Qi Qin, Yichen Huang, Xiaofan Tian, Chao Sun, Binbin Li, Zhengxin Wang, Xin Zhang   +9 more
wiley   +1 more source

Compromised Mitochondrial Protein Import Acts as a Signal for UPRmt

Cell Reports, 2019
Summary: The induction of the mitochondrial unfolded protein response (UPRmt) results in increased transcription of the gene encoding the mitochondrial chaperone HSP70. We systematically screened the C.
Stéphane G. Rolland, Sandra Schneid, Melanie Schwarz, Elisabeth Rackles, Christian Fischer, Simon Haeussler, Saroj G. Regmi, Assa Yeroslaviz, Bianca Habermann, Dejana Mokranjac, Eric Lambie, Barbara Conradt   +11 more
doaj   +1 more source

Silencing of Poly(ADP-Ribose) Polymerase-2 Induces Mitochondrial Reactive Species Production and Mitochondrial Fragmentation

Cells, 2021
PARP2 is a DNA repair protein. The deletion of PARP2 induces mitochondrial biogenesis and mitochondrial activity by increasing NAD+ levels and inducing SIRT1 activity.
Laura Jankó, Tünde Kovács, Miklós Laczik, Zsanett Sári, Gyula Ujlaki, Gréta Kis, Ibolya Horváth, Miklós Antal, László Vígh, Bálint L. Bálint, Karen Uray, Péter Bai   +11 more
doaj   +1 more source

PKR Mediates the Mitochondrial Unfolded Protein Response through Double-Stranded RNA Accumulation under Mitochondrial Stress. [PDF]

Int J Mol Sci
Mitochondrial stress, resulting from dysfunction and proteostasis disturbances, triggers the mitochondrial unfolded protein response (UPRMT), which activates gene encoding chaperones and proteases to restore mitochondrial function.
Kusuma F, Park S, Nguyen KA, Elvira R, Lee D, Han J.   +5 more
europepmc   +2 more sources

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source

The Mitochondrial Unfolded Protein Response Protects against Anoxia in Caenorhabditis elegans. [PDF]

PLoS ONE, 2016
The mitochondrial unfolded protein response (UPRmt) is a surveillance pathway that defends proteostasis in the "powerhouse" of the cell. Activation of the UPRmt protects against stresses imposed by reactive oxygen species, respiratory chain deficits, and
Salvador Peña, Teresa Sherman, Paul S Brookes, Keith Nehrke   +3 more
doaj   +1 more source

The Role of Mitochondrial Dysfunction and ER Stress in TDP-43 and C9ORF72 ALS

Frontiers in Cellular Neuroscience, 2021
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease of the motor system with complex determinants, including genetic and non-genetic factors.
Ruxandra Dafinca, Paola Barbagallo, Kevin Talbot   +2 more
doaj   +1 more source

Mitophagy and the mitochondrial unfolded protein response in neurodegeneration and bacterial infection [PDF]

BMC Biology, 2015
Mitochondria are highly dynamic and structurally complex organelles that provide multiple essential metabolic functions. Mitochondrial dysfunction is associated with neurodegenerative conditions such as Parkinson's disease, as well as bacterial infection.
Pellegrino, Mark W, Haynes, Cole M
openaire   +2 more sources

Dual‐Organelle Secretome Conjugation and Organ‐Uptake Tracking (DuO‐SCOUT) Enables Deep and Sensitive Mapping of the Secreted Proteins

Advanced Science, EarlyView.
A novel dual‐organelle proximity labeling platform, DuO‐SCOUT, decodes the complex landscape of systemic organ‐organ communication by capturing both classical and unconventional secretomes. Application in metabolic models maps the adipose‐to‐brain secretory relay, identifying selective extra‐hypothalamic sites for adipose‐derived factors and expanding ...
Fenglian Yang, Rui Qian, Jiaxing Song, Xingqi Meng, Jin Young Kim, Kwok On Lai, Li Wang, Liang Zhang   +7 more
wiley   +1 more source