Results 91 to 100 of about 8,821,559 (269)

Senescent Hepatocytes in Decompensated Liver Show Reduced UPRMT and Its Key Player, CLPP, Attenuates Senescence In VitroSummary

Cellular and Molecular Gastroenterology and Hepatology, 2019
Background and Aims: Non-dividing hepatocytes in end-stage liver disease indicates permanent growth arrest similar to senescence. Identifying senescence in vivo is often challenging and mechanisms inhibiting senescence are poorly understood.
Bijoya Sen, Archana Rastogi, Rhisita Nath, Saggere M. Shasthry, Viniyendra Pamecha, Sonika Pandey, Kapuganti Jagadis Gupta, Shiv K. Sarin, Nirupma Trehanpati, Gayatri Ramakrishna   +9 more
doaj   +1 more source

A multi-omics analysis reveals the unfolded protein response regulon and stress-induced resistance to folate-based antimetabolites

Nature Communications, 2020
The unfolded protein response (UPR) is a stress response pathway implicated in numerous diseases and chemotherapy resistance. Here, the authors define the UPR regulon with a multi-omics strategy, uncovering changes to mitochondrial one-carbon metabolism ...
Stefan Reich, Chi D. L. Nguyen, Canan Has, Sascha Steltgens, Himanshu Soni, Cristina Coman, Moritz Freyberg, Anna Bichler, Nicole Seifert, Dominik Conrad, Christiane B. Knobbe-Thomsen, Björn Tews, Grischa Toedt, Robert Ahrends, Jan Medenbach   +14 more
doaj   +1 more source

The mitochondrial unfolded protein response: acting near and far

Biological Chemistry
Abstract Mitochondria are central hubs of cellular metabolism and their dysfunction has been implicated in a variety of human pathologies and the onset of aging. To ensure proper mitochondrial function under misfolding stress, a retrograde mitochondrial signaling pathway known as UPRmt is activated.
Nikolaos Charmpilas, Qiaochu Li, Thorsten Hoppe   +2 more
openaire   +2 more sources

Temporal Trajectories of the Tau Aggregate Interactome Reveal Stage‐Specific Vulnerabilities in Alzheimer's Disease

Advanced Science, EarlyView.
Tau populations with different aggregation states associate with distinct sets of proteins in the Alzheimer's disease brain. Proteomic discovery combined with single‐molecule analysis in neurons reveals dynamic associations involving proteostasis, metabolism and RNA biology.
Dorothea Böken, Paula Beltran Lobo, Yunzhao Wu, Lyla A. Rowe, Emre Fertan, Cara L. Croft, Maria Jimenez‐Sanchez, Dezerae Cox, David Klenerman   +8 more
wiley   +1 more source

Persistent Zn2+ Influx‐Mediated Deacetylation of ANXA2 Regulates the “Zn2+‐Autophagic Flux” and Alleviates Intervertebral Disc Degeneration

Advanced Science, EarlyView.
Zinc transporter SLC39A14 sustains intracellular Zn2+ levels to activate SIRT3‑dependent ANXA2 deacetylation at K302. This modification weakens ANXA2‑mTOR binding and releases autophagic‑flux suppression in nucleus pulposus cells. Dysregulated Zn2+ homeostasis disrupts this axis to drive intervertebral disc degeneration.
Yuxin Jin, Yongcheng Chen, Yihao Xie, Dongyang Hu, Longhui Gong, Zhihua Chen, Linjie Chen, Minhao Gao, Qizhu Chen, Morgan Jones, Hui Wang, Xiuling You, Kenny Yat Hong Kwan, Shoutao Weng, Taidong Lyu, Xiang Chen, Yuxiao Zhu, Yusheng Wang, Bin Li, Xiangyang Wang, Xiaofeng Jia, Kailiang Zhou, Ouqiang Wu, Aimin Wu   +23 more
wiley   +1 more source

Multiple Molecular Mechanisms Rescue mtDNA Disease in C. elegans

Cell Reports, 2018
Summary: Genetic instability of the mitochondrial genome (mtDNA) plays an important role in human aging and disease. Thus far, it has proven difficult to develop successful treatment strategies for diseases that are caused by mtDNA instability.
Suraiya Haroon, Annie Li, Jaye L. Weinert, Clark Fritsch, Nolan G. Ericson, Jasmine Alexander-Floyd, Bart P. Braeckman, Cole M. Haynes, Jason H. Bielas, Tali Gidalevitz, Marc Vermulst   +10 more
doaj   +1 more source

Consensus clustering and functional interpretation of gene-expression data [PDF]

, 2004
Microarray analysis using clustering algorithms can suffer from lack of inter-method consistency in assigning related gene-expression profiles to clusters.
Liu, X, Orengo, Christine, Martin, N, Kellam, P., Paul Kellam, Liu, X., Swift, Stephen, Swift, S, Orengo, C.A., Tucker, Allan, Tucker, A., Tucker, A, Liu, XH, Allan Tucker, Vinciotti, Veronica, Christine Orengo, Veronica Vinciotti, Vinciotti, V., Xiaohui Liu, Swift, S., Kellam, P, Liu, Xiaohui, Vinciotti, V, Stephen Swift, Kellam, Paul, Orengo, C, Martin, Nigel, Nigel Martin   +27 more
core   +1 more source

Salvianolic Acid a Disrupts the HSP90α‐AKT‐PERK Ternary Complex to Alleviate Atherosclerosis by Activating Endoplasmic Reticulum Stress of Senescent Vascular Smooth Muscle Cells

Advanced Science, EarlyView.
Salvianolic acid A (SAA) selectively induces senescent vascular smooth muscle cell apoptosis, alleviating atherosclerosis. Mechanistically, SAA targets heat shock protein 90 alpha (HSP90α) to disrupt the protein inase B (AKT)‐PRKR‐Like Endoplasmic Reticulum Kinase (PERK) scaffold, driving ubiquitin‐proteasome‐dependent AKT degradation.
Xiuya Guan, Mengkai Lu, Xinhai Cui, Dawei Zhang, Lei Zhang, Lin Lin, Yuan Li, Yuanlong Hu, Chao Li   +8 more
wiley   +1 more source

Mitochondrial heat shock protein 70, a molecular chaperone for proteins encoded by mitochondrial DNA [PDF]

, 1994
Mitochondrial heat shock protein 70 (mt-Hsp70) has been shown to play an important role in facilitating import into, as well as folding and assembly of nuclear-encoded proteins in the mitochondrial matrix.
Herrmann, Johannes M., Stuart, Rosemary A., Neupert, Walter, Craig, Elisabeth A.   +3 more
core   +2 more sources

The loss of LRPPRC function induces the mitochondrial unfolded protein response

Aging, 2015
The inactivation of the LRPPRC gene, which has previously been associated with the neurodegenerative French Canadian Leigh Syndrome, results in a decrease in the production of mitochondria-encoded subunits of complex IV, thereby causing a reduction in complex IV activity.
Fabian, Köhler, Anne Kathrin, Müller-Rischart, Barbara, Conradt, Stéphane Guy, Rolland   +3 more
openaire   +2 more sources