Results 101 to 110 of about 8,821,559 (269)

Bioenergetic Materials for Tissue Regeneration: Modulating Metabolism to Promote Cellular Anabolism

Advanced Science, EarlyView.
Bioenergetic materials (BEMs) modulate cellular metabolism to promote tissue regeneration. Their principal mechanisms of action include metabolic substrate supplementation, metabolic enzyme modulation, organelle transfer, electrical current regulation, redox homeostasis modulation, and oxygen tension modulation.
Yuchen He, Yuwen Wang, Jonathan F. Gong, Yiting Lei, Fei Jin, Weihong Zhu, Rocky S. Tuan, Zhong Alan Li   +7 more
wiley   +1 more source

A morphological view on mitochondrial protein targeting [PDF]

, 1994
Mitochondrial protein targeting includes both intramitochondrial sorting of proteins encoded by the organellar genome and import and subsequent sorting of nuclear encoded precursor proteins. Only a few proteins are encoded by the mitochondrial genome and
Ida J. van der Klei, Walter Neupert, Neupert, Walter, Marten Veenhuis, Veenhuis, Marten, Klei, Ida J. van der   +5 more
core   +1 more source

Glutaminolysis Blockade‐Empowered Bimodal Nanodepot for Spatially Complementary Sono‐Thermal Ablation via PANoptosis and STING Activation Against Large Tumors

Advanced Science, EarlyView.
An injectable bimodal TCPD nanodepot disrupts glutaminolysis and TCA metabolism, sensitizing large tumors to spatially complementary sono‐thermal ablation for complete treatment coverage. This intervention induces mitochondrial and endoplasmic reticulum dysfunction, genotoxicity, and NAD+ depletion, converging to trigger PANoptosome assembly and ...
Yi‐Ming Liu, Juan Qin, Si‐Yuan Wu, Xue‐Zhen Zhu, Yun‐Fei Cai, Pei‐Yao Sun, Hao Yang, Xing‐Yue Wang, Shu Li, Duo Wang, Hai‐Dong Zhu   +10 more
wiley   +1 more source

Mitochondrial Unfolded Protein Response Gene Clpp Is Required for Oocyte Function and Female Fertility. [PDF]

Int J Mol Sci
Mitochondrial unfolded protein stress response (mtUPR) plays a critical role in regulating cellular and metabolic stress response and helps maintain protein homeostasis.
Ergun Y, Imamoglu AG, Cozzolino M, Demirkiran C, Basar M, Garg A, Yildirim RM, Seli E.   +7 more
europepmc   +2 more sources

Green fluorescent protein-based monitoring of endoplasmic reticulum redox poise [PDF]

, 2013
Pathological endoplasmic reticulum (ER) stress is tightly linked to the accumulation of reactive oxidants, which can be both upstream and downstream of ER stress.
Julia Birk, Thomas Ramming, Alex Odermatt, Julia eBirk, Thomas eRamming, Alex eOdermatt, Birk, Julia, Christian eAppenzeller-Herzog, Ramming, Thomas, Appenzeller-Herzog, Christian, Odermatt, Alex, Christian Appenzeller-Herzog, Ramming T, Appenzeller-Herzog C, Birk J, Odermatt A   +15 more
core   +1 more source

Molecular Landscapes of Tumor Dormancy in Gynecologic Malignancies: From Survival Mechanisms to Precision Interception

Advanced Science, EarlyView.
This Review outlines the biological framework of entry, maintenance, and awakening in dormant minimal residual disease across gynecologic cancers. By mapping critical biological dependencies—from metabolic plasticity to microenvironment interactions—it evaluates novel interception concepts and presents a translational framework combining single‐cell ...
Shih‐Hsuan Cheng, Ren‐Wang Peng, Chang‐Cheng Wu, Chi‐Wen Luo, Emmanuel Naveen Raj, Zhi‐Hong Wen, Tzu‐Hung Hsiao, Chia‐Jung Li   +7 more
wiley   +1 more source

Eliciting the mitochondrial unfolded protein response via NAD(+) repletion reverses fatty liver disease [PDF]

, 2015
With no approved pharmacological treatment, non-alcoholic fatty liver disease (NAFLD) is now the most common cause of chronic liver disease in western countries and its worldwide prevalence continues to increase along with the growing obesity epidemic ...
Karim Gariani, Pham, Tho X, Siah Ku, Chai, Wang, Xu, Perino, Alessia, Norman Moullan, Koo, Sung I, Moullan, Norman, Cantó, Carlos, Anthony A. Sauve, Dongryeol Ryu, Auwerx, Johan, Zhang, Hongbo, Vera Lemos, Kristina Schoonjans, Piersigilli, Alessandra, Ropelle, Eduardo R, Eduardo R. Ropelle, Lemos, Vera, Johan Auwerx, Wegner, Casey J, Anna Fomitchova, Schoonjans, Kristina, Alessia Perino, Park, Young-Ki, Gariani, Karim, Menzies, Keir J, Lee, Ji-Young, Hongbo Zhang, Bohkyung Kim, Carlos Cantó, Kim, Bohkyung, Ji‐Young Lee, Casey J. Wegner, Alessandra Piersigilli, Sauve, Anthony A, Ryu, Dongryeol, Yue Yang, Chai Siah Ku, Keir J. Menzies, Xu Wang, Ku, Chai Siah, Tho X. Pham, Fomitchova, Anna, Young‐Ki Park, Yang, Yue, Sung I. Koo, Menzies, Keir Joe, Zhang H, Sung I.; Fomitchova, A; Canto, Pham TX, Park YK, Perino A, CJ; Wang, Canto Alvarez, Carlos, Cantó C, Auwerx J, Young-Ki; Piersigilli, Ryu D, Casey J.; Wang, Carlos; Schoonjans, Menzies, Keir J., Chai Siah; Koo, Kim B, YK; Piersigilli, Eduardo R.; Moullan, J, K; Menzies, ER; Moullan, Menzies KJ, Pham, Tho X., Gariani, Alessia; Lemos, Johan, Sauve AA, B; Park, Koo SI, Kristina; Sauve, Gariani, Karim Laurent, A; Lemos, Y; Ku, Lee JY, Wenger, Casey J, Dongryeol; Wegner, Gariani K, A; Pham, KJ; Ryu, D; Wegner, K; Sauve, Piersigilli A, C; Schoonjans, TX; Yang, Ku CS, Moullan N, Karim; Menzies, Wang X, Bohkyung; Park, CS; Koo, Anna; Canto, Sauve, Anthony A., Xu; Ropelle, Ropelle ER, H; Perino, SI; Fomitchova, Yang Y, Keir J.; Ryu, Wegner CJ, V; Kim, Wegner, Casey J., AA; Lee, Anthony A.; Lee, Tho X.; Yang, Ji-Young; Auwerx, Vera; Kim, Yue; Ku, Fomitchova A, Lemos V, Lemos Da Silva, Vera Monica, Norman; Zhang, N; Zhang, Koo, Sung I., Schoonjans K, Hongbo; Perino, JY; Auwerx, X; Ropelle, Alessandra; Pham, Ropelle, Eduardo R.   +127 more
core   +2 more sources

AARS2‐SIRT5‐Driven DLD K445 Lactylation Promotes Cuproptosis Resistance in Glioblastoma Stem Cells

Advanced Science, EarlyView.
Lactylation of DLD at K445 by AARS2 suppresses PDH complex activity and reduces DLAT lipoylation, thereby conferring cuproptosis resistance in glioblastoma stem cells. SIRT5‐mediated delactylation restores PDH function and enhances cuproptosis sensitivity.
Mingtian Ding, Haibiao Xu, Cen Liu, Yangyin Ding, Shuai Wang, Jun Yin, Tao Fu, Xiao Jiang, Yuning Chen, Hui Luo, Rui Li, Zhengxin Chen, Huibo Wang   +12 more
wiley   +1 more source

Single-molecule fluorescence studies of Protein Folding and Molecular Chaperones [PDF]

, 2011
Folding of newly synthesized proteins is an essential part of protein biosynthesis and misfolding can result in protein aggregation which can also lead to several severe diseases.
Sikor, Martin
core   +1 more source

Photoactivated Platinum Complexes: Targeting Membrane Proteins and Organelles for Precision Cancer Therapy

Angewandte Chemie, EarlyView.
This review highlights an emerging anticancer approach integrating platinum agents into photodynamic therapy (PDT) and photoactivated chemotherapy (PACT) systems, further augmented by cancer cell membrane‐ and organelle‐targeting. By directing photoactivated platinum complexes from nontargeted distribution to cancer cells or defined subcellular sites ...
Shu Chen, Qiyuan Zhou, Jiaqian Xu, Guangyu Zhu   +3 more
wiley   +2 more sources