Results 41 to 50 of about 8,821,559 (269)
Mitochondrial Dysfunction in Bacterial Infections
Pathogens, 2023 Mitochondria are critical in numerous cellular processes, including energy generation. Bacterial pathogens target host cell mitochondria through various mechanisms to disturb the host response and improve bacterial survival.
Nicholas M. Maurice, Ruxana T. Sadikot
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Ubiquitin-proteasome dependent mitochondrial protein quality control [PDF]
, 2014 Dysfunctional mitochondria cause many neurodegenerative disorders and with aging in general, mechanisms of mitochondrial quality control are essential for cellular function.
Benischke, Anne-Sophie
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Evaluating and responding to mitochondrial dysfunction: the mitochondrial unfolded-protein response and beyond [PDF]
Trends in Cell Biology, 2013 During development and cellular differentiation, tissue- and cell-specific programs mediate mitochondrial biogenesis to meet physiological needs. However, environmental and disease-associated factors can perturb mitochondrial activities, requiring cells to adapt to protect mitochondria and maintain cellular homeostasis. Several mitochondrion-to-nucleus
Cole M, Haynes +2 more
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Maintenance and propagation of a deleterious mitochondrial genome by the mitochondrial unfolded protein response [PDF]
Nature, 2016 Mitochondrial genomes (mitochondrial DNA, mtDNA) encode essential oxidative phosphorylation (OXPHOS) components. Because hundreds of mtDNAs exist per cell, a deletion in a single mtDNA has little impact. However, if the deletion genome is enriched, OXPHOS declines, resulting in cellular dysfunction.
Yi-Fan, Lin +5 more
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The mitochondrial unfolded protein response (UPRmt) protects against osteoarthritis
Experimental & Molecular Medicine, 2022 AbstractThe mitochondrial unfolded protein response (UPRmt) is a mitochondrial-to-nuclear signaling pathway that is activated to maintain mitochondrial function when there is an accumulation of misfolded proteins within mitochondria. Mitochondrial function is essential for chondrocyte homeostasis, and mitochondrial dysfunction is a characteristic of ...
Zhou, Zhibin +6 more
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Mitohormesis Primes Tumor Invasion and Metastasis
Cell Reports, 2019 Summary: Moderate mitochondrial stress can lead to persistent activation of cytoprotective mechanisms – a phenomenon termed mitohormesis. Here, we show that mitohormesis primes a subpopulation of cancer cells to basally upregulate mitochondrial stress ...
Timothy C. Kenny +3 more
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The Unfolded Protein Response and its potential role in Huntington's disease [PDF]
, 2012 Huntington's disease (HD) is a progressive, neurodegenerative disease with fatal outcome. Although the disease-causing gene (huntingtin) has been known for some time, the exact cause of neuronal cell death is still unknown.
Ravi K. R. Kalathur +2 more
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Genetics, 2022 Abstract We review the findings that establish that perturbations of various aspects of mitochondrial function, including oxidative phosphorylation, can promote lifespan extension, with different types of perturbations acting sometimes independently and additively on extending lifespan.
Cole M Haynes, Siegfried Hekimi
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UPRmt and coordinated UPRER in type 2 diabetes
Frontiers in Cell and Developmental Biology, 2022 The mitochondrial unfolded protein response (UPRmt) is a molecular mechanism that maintains mitochondrial proteostasis under stress and is closely related to various metabolic diseases, such as type 2 diabetes (T2D).
Zhanfang Kang +6 more
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Bidirectional crosstalk between endoplasmic reticulum stress and mTOR signaling [PDF]
, 2012 Many cellular processes including apoptosis, autophagy, translation, energy metabolism, and inflammation are controlled by the mammalian target of rapamycin (mTOR) kinase and the endoplasmic reticulum (ER) stress pathway, also known as the unfolded ...
Appenzeller-Herzog, Christian +3 more
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