Results 11 to 20 of about 8,821,559 (269)
Effect of the mitochondrial unfolded protein response on hypoxic death and mitochondrial protein aggregation [PDF]
Cell Death and Disease, 2021 Mitochondria are the main oxygen consumers in cells and as such are the primary organelle affected by hypoxia. All hypoxia pathology presumably derives from the initial mitochondrial dysfunction. An early event in hypoxic pathology in C.
Junyi Yan +4 more
doaj +6 more sources
Nature Communications, 2023 Accumulating evidence indicates that mitochondria play crucial roles in immunity. However, the role of the mitochondrial Krebs cycle in immunity remains largely unknown, in particular at the organism level.
Eunah Kim +13 more
doaj +5 more sources
The different axes of the mammalian mitochondrial unfolded protein response [PDF]
BMC Biology, 2018 Mitochondria are sensitive to numerous environmental stresses, which can lead to activation of mitochondrial stress responses (MSRs). Of particular recent interest has been the mitochondrial unfolded protein response (UPRmt), activated to restore protein
Christian Münch
doaj +4 more sources
Mitochondrial unfolded protein response gene CLPP changes mitochondrial dynamics and affects mitochondrial function [PDF]
PeerJ, 2019 Mitochondrial dynamics is associated with mitochondrial function, which is associated with diabetes. Although an important indicator of the mitochondrial unfolded protein response, to the best of our knowledge, CLPP and its effects on mitochondrial ...
GuiJun Wu +10 more
doaj +5 more sources
Cells, 2022 The development and application of high-throughput omics technologies have enabled a more in-depth understanding of mitochondrial biosynthesis metabolism and the pathogenesis of mitochondrial diseases.
Hedong Lu +9 more
doaj +4 more sources
The mitochondrial unfolded protein response - synchronizing genomes [PDF]
Current Opinion in Cell Biology, 2015 Maintenance of the mitochondrial proteome is performed primarily by chaperones, which fold and assemble proteins, and by proteases, which degrade excess damaged proteins.
Jovaisaite, Virginija +3 more
core +5 more sources
Folding Mitochondrial-Mediated Cytosolic Proteostasis Into the Mitochondrial Unfolded Protein Response [PDF]
Frontiers in Cell and Developmental Biology, 2021 Several studies reported that mitochondrial stress induces cytosolic proteostasis. How mitochondrial stress activates proteostasis in the cytosol remains unclear.
Edmund Charles Jenkins +2 more
doaj +3 more sources
Cell Reports, 2018 Summary: Endoplasmic reticulum (ER) stress is transmitted to mitochondria and is associated with pathologic mitochondrial dysfunction in diverse diseases.
Justine Lebeau +6 more
doaj +2 more sources
The chop gene contains an element for the positive regulation of the mitochondrial unfolded protein response. [PDF]
PLoS ONE, 2007 We have previously reported on the discovery of a mitochondrial specific unfolded protein response (mtUPR) in mammalian cells, in which the accumulation of unfolded protein within the mitochondrial matrix results in the transcriptional activation of ...
Tomohisa Horibe, Nicholas J Hoogenraad
doaj +2 more sources
TDP-43 induces mitochondrial damage and activates the mitochondrial unfolded protein response.
PLoS Genetics, 2019 Mutations in or dys-regulation of the TDP-43 gene have been associated with TDP-43 proteinopathy, a spectrum of neurodegenerative diseases including Frontotemporal Lobar Degeneration (FTLD) and Amyotrophic Lateral Sclerosis (ALS).
Peng Wang +14 more
doaj +3 more sources