Results 51 to 60 of about 426,171 (247)
Cell Death and Disease, 2021 Retinal degeneration diseases (RDDs) are common and devastating eye diseases characterized by the degeneration of photoreceptors, which are highly associated with oxidative stress.
Biting Zhou +7 more
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The eIF2α kinase HRI in innate immunity, proteostasis, and mitochondrial stress [PDF]
The FEBS Journal, 2020 The integrated stress response (ISR) is an evolutionary conserved stress response pathway that leads to a global arrest in translation as well as to the expression of specific genes, such as the transcription factor ATF4, to promote cellular recovery.
Arnoult, Damien +3 more
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Biomolecules, 2023 Mitochondria play a key role in cellular functions, including energy production and oxidative stress regulation. For this reason, maintaining mitochondrial homeostasis and proteostasis (homeostasis of the proteome) is essential for cellular health ...
Paula Cilleros-Holgado +11 more
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FEBS Open Bio, 2020 The mitochondrial unfolded protein response (UPRmt) is characterized by the transcriptional induction of mitochondrial chaperone and protease genes in response to impaired mitochondrial proteostasis and is regulated by ATF5 and CHOP in mammalian cells ...
Arpit Katiyar +7 more
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Mitochondria organize the cellular proteostatic response and promote cellular senescence
Cell Stress, 2019 Mitochondria have relatively independent protein quality control systems, including their own chaperones for protein folding and AAA proteases for protein degradation.
Yanjun Li +3 more
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The Journal of Clinical Investigation, 2022 Germline mutations that activate genes in the canonical RAS/MAPK signaling pathway are responsible for rare human developmental disorders known as RASopathies.
Laetitia Dard +22 more
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Mitochondrial autophagy in the sleeping brain
Frontiers in Cell and Developmental Biology, 2022 A significant percentage of the mitochondrial mass is replaced on a daily basis via mechanisms of mitochondrial quality control. Through mitophagy (a selective type of autophagy that promotes mitochondrial proteostasis) cells keep a healthy pool of ...
Sofia Mauri +4 more
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Engineered AAA+ proteases reveal principles of proteolysis at the mitochondrial inner membrane
Nature Communications, 2016 Human YME1L is a membrane-anchored AAA+ protease that maintains proteostasis in the mitochondrial inner membrane and intermembrane space. Here the authors probe the substrate-binding and degradation activities of YME1L and suggest the existence of ...
Hui Shi +2 more
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Mitochondrial DNA variants modulate N-formylmethionine, proteostasis and risk of late-onset human diseases. [PDF]
, 2021 Mitochondrial DNA (mtDNA) variants influence the risk of late-onset human diseases, but the reasons for this are poorly understood. Undertaking a hypothesis-free analysis of 5,689 blood-derived biomarkers with mtDNA variants in 16,220 healthy donors ...
core +3 more sources
Altered transcriptome-proteome coupling indicates aberrant proteostasis in Parkinson’s disease
iScience, 2023 Summary: Aberrant proteostasis is thought to be implicated in Parkinson’s disease (PD), but patient-derived evidence is scant. We hypothesized that impaired proteostasis is reflected as altered transcriptome-proteome correlation in the PD brain.
Fiona Dick +4 more
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