Results 61 to 70 of about 426,171 (247)

MitoTraP: mitochondrial protection for cellular proteostasis

Trends in Biochemical Sciences
Cells depend on the efficient import of thousands of nuclear-encoded mitochondrial proteins to maintain mitochondrial function. A new study by Flohr et al. reveals a quality control strategy that traps a subset of mitochondrial precursors in the intermembrane space during energy stress, preventing their toxic accumulation in the cytosol or nucleus.
Michaela Oborská-Oplová, Michael A. Ruoss, Vikram G. Panse   +2 more
openaire   +2 more sources

Control of mitochondrial biogenesis and function by the ubiquitin–proteasome system [PDF]

Open Biology, 2017
Mitochondria are pivotal organelles in eukaryotic cells. The complex proteome of mitochondria comprises proteins that are encoded by nuclear and mitochondrial genomes. The biogenesis of mitochondrial proteins requires their transport in an unfolded state
Piotr Bragoszewski, Michal Turek, Agnieszka Chacinska   +2 more
doaj   +1 more source

Phytochemical compound PB125 attenuates skeletal muscle mitochondrial dysfunction and impaired proteostasis in a model of musculoskeletal decline [PDF]

, 2023
Impaired mitochondrial function and disrupted proteostasis contribute to musculoskeletal dysfunction. However, few interventions simultaneously target these two drivers to prevent musculoskeletal decline. Nuclear factor erythroid 2-related factor 2 (Nrf2)
Walsh, Maureen A., Hamilton, Karyn L., Musci, Robert V., Bork, Sydney, Martinez, Richard, Wist, Sara, Murrell, Meredith D., Javors, Martin A., Santangelo, Kelly S., Nguyen, Tessa, Zhang, Qian, McCord, Joe M., Valenti, Zackary J., Afzali, Maryam F., Campbell, Margaret, Sanford, Joseph, Kail, Thomas E., Andrie, Kendra M., Hybertson, Brooks M., Johnson, Taylor, Linden, Melissa A.   +20 more
core  

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Sirt1 coordinates the mitochondrial UPR and myocellular proteostasis to preserve muscle integrity during muscle atrophy in zebrafish

Frontiers in Cell and Developmental Biology
IntroductionThe decline of mitochondrial homeostasis and proteostasis, the two key cell quality control mechanisms, is the hallmark of aging and age-related diseases.
Qing Chen, Yu-Lun Chang, Miao-Wen Hung, Po-Lin Lee, Chen Hsin, Yi-Fan Lin, Yi-Fan Lin   +6 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Lipid-polymer nanoparticles to probe the native-like environment of intramembrane rhomboid protease GlpG and its activity

Nature Communications
Polymers can facilitate detergent-free extraction of membrane proteins into nanodiscs (e.g., SMALPs, DIBMALPs), incorporating both integral membrane proteins as well as co-extracted native membrane lipids.
Henry Sawczyc, Takashi Tatsuta, Carl Öster, Spyridon Kosteletos, Sascha Lange, Claudia Bohg, Thomas Langer, Adam Lange   +7 more
doaj   +1 more source

Mitochondrial function in neuronal cells depends on p97/VCP/Cdc48-mediated quality control

Frontiers in Cellular Neuroscience, 2015
Maintaining mitochondrial function is essential for neuronal survival and offers protection against neurodegeneration. Ubiquitin-mediated, proteasome-dependent protein degradation in the form of outer mitochondrial membrane associated degradation (OMMAD)
Lei eFang, Charles eHemion, Ana Catarina Pinho Ferreira Bento, Claudia C Bippes, Josef eFlammer, Albert eNeutzner, Albert eNeutzner   +6 more
doaj   +1 more source

Mitochondrial cross-compartmental signalling to maintain proteostasis and longevity

Philosophical Transactions of the Royal Society B: Biological Sciences, 2020
Lifespan in eukaryotic species can be prolonged by shifting from cellular states favouring growth to those favouring maintenance and stress resistance. For instance, perturbations in mitochondrial oxidative phosphorylation (OXPHOS) can shift cells into this latter state and extend lifespan. Because mitochondria rely on proteins synthesized from nuclear
Marte Molenaars, Eileen G. Daniels, Amber Meurs, Georges E. Janssens, Riekelt H. Houtkooper   +4 more
openaire   +3 more sources

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source