Results 11 to 20 of about 426,171 (247)

The Role of Exercise in Maintaining Mitochondrial Proteostasis in Parkinson’s Disease [PDF]

International Journal of Molecular Sciences, 2023
Parkinson’s disease (PD) is the second most common rapidly progressive neurodegenerative disease and has serious health and socio-economic consequences. Mitochondrial dysfunction is closely related to the onset and progression of PD, and the use of
Jianshe Wei, Yuxiang Xu, Yanli Xu
exaly   +5 more sources

Mitochondrial proteostasis regulated by CRL5Ozz and Alix modulates skeletal muscle metabolism and fiber type [PDF]

Communications Biology
High-energy-demanding tissues, such as skeletal muscle, rely on mitochondrial proteostasis for proper function. Two key quality-control mechanisms -the ubiquitin proteasome system (UPS) and the release of mitochondria-derived vesicles- help maintain ...
Yvan Campos, Gustavo Palacios, Elida Gomero, Diantha van de Vlekkert, Krishnan Venkataraman, Jaison John, Jason Andrew Weesner, Randall Wakefield, Xiaohui Qiu, Ricardo Rodriguez-Enriquez, Stephanie Rockfield, Jeroen Demmers, Joseph T. Opferman, Cam Robinson, Khaled Khairy, Tulio Bertorini, Gerard C. Grosveld, Alessandra d’Azzo   +17 more
doaj   +3 more sources

Quality Control of Mitochondrial Proteostasis [PDF]

Cold Spring Harbor Perspectives in Biology, 2011
A decline in mitochondrial activity has been associated with aging and is a hallmark of many neurological diseases. Surveillance mechanisms acting at the molecular, organellar, and cellular level monitor mitochondrial integrity and ensure the maintenance
T. Tatsuta, M. J. Baker, Tatsuta, T., Langer, T., Baker, M., T. Langer   +5 more
core   +4 more sources

Mitochondrial Proteostasis Requires Genes Encoded in a Neurodevelopmental Syndrome Locus. [PDF]

J Neurosci, 2021
Eukaryotic cells maintain proteostasis through mechanisms that require cytoplasmic and mitochondrial translation. Genetic defects affecting cytoplasmic translation perturb synapse development, neurotransmission, and are causative of neurodevelopmental ...
Gokhale A, Lee CE, Zlatic SA, Freeman AAH, Shearing N, Hartwig C, Ogunbona O, Bassell JL, Wynne ME, Werner E, Xu C, Wen Z, Duong D, Seyfried NT, Bearden CE, Oláh VJ, Rowan MJM, Glausier JR, Lewis DA, Faundez V.   +19 more
europepmc   +7 more sources

Mitochondrial Inorganic Polyphosphate Is Required to Maintain Proteostasis Within the Organelle [PDF]

Frontiers in Cell and Developmental Biology
The existing literature points towards the presence of robust mitochondrial mechanisms aimed at mitigating protein dyshomeostasis within the organelle. However, the precise molecular composition of these mechanisms remains unclear.
Ernest R Scoma, Renata T da Costa, Pia A Elustondo   +2 more
exaly   +4 more sources

Immunoproteasome-specific subunit PSMB9 induction is required to regulate cellular proteostasis upon mitochondrial dysfunction [PDF]

Nature Communications, 2023
Perturbed cellular protein homeostasis (proteostasis) and mitochondrial dysfunction play an important role in neurodegenerative diseases, however, the interplay between these two phenomena remains unclear.
Minji Kim, Remigiusz A. Serwa, Lukasz Samluk, Ida Suppanz, Agata Kodroń, Tomasz M. Stępkowski, Praveenraj Elancheliyan, Biniyam Tsegaye, Silke Oeljeklaus, Michal Wasilewski, Bettina Warscheid, Agnieszka Chacinska   +11 more
doaj   +2 more sources

Enhancing Mitochondrial Proteostasis Reduces Amyloid-β Proteotoxicity [PDF]

Nature, 2017
Alzheimer's disease is a common and devastating disease characterized by aggregation of the amyloid-β peptide. However, we know relatively little about the underlying molecular mechanisms or how to treat patients with Alzheimer's disease. Here we provide bioinformatic and experimental evidence of a conserved mitochondrial stress response signature ...
John S Beck, Hongbo Zhang, Johan Auwerx
exaly   +7 more sources

Neurodegenerative stress related mitochondrial proteostasis [PDF]

, 2015
1.1 Background: Mitochondria are the main site of energy production in most cells. Furthermore, they are involved in a multitude of other essential cellular processes, such as regulating the cellular calcium pool, lipid metabolism and programmed cell ...
Fang, Lei
core   +3 more sources

Proteostasis and Mitochondrial Role on Psychiatric and Neurodegenerative Disorders: Current Perspectives

Neural Plasticity, 2018
Proteostasis involves processes that are fundamental for neural viability. Thus, protein misfolding and the formation of toxic aggregates at neural level, secondary to dysregulation of the conservative mechanisms of proteostasis, are associated with ...
Pablo Olivero, Carlo Lozano, Ramón Sotomayor-Zárate, Nicolás Meza-Concha, Marcelo Arancibia, Claudio Córdova, Wilfredo González-Arriagada, Ricardo Ramírez-Barrantes, Ivanny Marchant   +8 more
doaj   +2 more sources

Unveiling the intercompartmental signaling axis: Mitochondrial to ER Stress Response (MERSR) and its impact on proteostasis. [PDF]

PLoS Genetics
Maintaining protein homeostasis is essential for cellular health. Our previous research uncovered a cross-compartmental Mitochondrial to Cytosolic Stress Response, activated by the perturbation of mitochondrial proteostasis, which ultimately results in ...
Jeson J Li, Nan Xin, Chunxia Yang, Bo G Kim, Larissa A Tavizon, Ruth Hong, Jina Park, Travis I Moore, Rebecca George Tharyan, Adam Antebi, Hyun-Eui Kim   +10 more
doaj   +5 more sources