Results 121 to 130 of about 18,307 (208)

Chemical activation of mitochondrial ClpP to modulate energy metabolism of CD4+ T cell for inflammatory bowel diseases treatment

Cell Reports Medicine
Summary: Inflammatory bowel disease (IBD) is an autoimmune disorder, and despite the availability of multiple Food and Drug Administration (FDA)-approved therapies, current clinical needs remain unmet. In this study, we find that caseinolytic protease P (
Jiangnan Zhang, Yunhan Jiang, Dongmei Fan, Zhiqiang Qiu, Xinlian He, Song Liu, Linjie Li, Zhengyi Dai, Lidan Zhang, Ziyi Shu, Lili Li, Hu Zhang, Tao Yang, Youfu Luo   +13 more
doaj   +1 more source

Local and systemic delivery of mRNA encoding survivin-T34A by lipoplex for efficient colon cancer gene therapy

International Journal of Nanomedicine, 2019
Xueyan Zhang,1 Ke Men,1 Yuanfa Zhang,1 Rui Zhang,1 Li Yang,1 Xingmei Duan21State Key Laboratory of Biotherapy and Cancer Center/Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, People’s ...
Zhang X, Men K, Zhang Y, Zhang R, Yang L, Duan X   +5 more
doaj  

DISSECTING THE ROLE OF CLPP IN MULTIPLE MYELOMA

, 2022
Despite the efficacy of targeted treatments, multiple myeloma (MM) is still incurable, urging to identify novel vulnerabilities to design more effective therapies. Mitochondria are emerging therapeutic targets in oncology for their crucial role not only as cellular powerhouses, but also in signalling, redox homeostasis, initiation of apoptosis ...
openaire   +1 more source

Polydatin as a natural ClpP modulator for combating methicillin-resistant <i>Staphylococcus aureus</i> infection. [PDF]

Front Cell Infect Microbiol
Qin Y, Yang J, Wang G, Yang L, Wang D, Luan Y.   +5 more
europepmc   +1 more source

Fred Goldberg machines in the pathogenesis of Mycobacterium tuberculosis. [PDF]

J Biol Chem
Darwin KH.
europepmc   +1 more source

Differential contributions of ClpX and ClpP to pulmonary virulence in classical and hypervirulent <i>Klebsiella pneumoniae</i>. [PDF]

Infect Immun
Lin NM, Marino EC, Schlotmann JM, Rosen DA.   +3 more
europepmc   +1 more source

Abdominal Leak Point Pressures During Cough and Valsalva: What Do the Different Maneuvers Hide? [PDF]

Cureus
Veiga E Moura C, Lopes A, Candoso B.
europepmc   +1 more source

Deficiency of MecA in Streptococcus mutans causes major defects in cell envelope biogenesis, cell division, and biofilm formation [PDF]

, 2018
Beatty, Wandy L, De, Arpan, Jorgensen, Ashton N, Lemos, Jose, Wen, Zezhang T   +4 more
core   +1 more source

ATP-dependent Clp protease proteolytic subunit (clpP) [PDF]

Science-Business eXchange, 2011
openaire   +1 more source

Regulation of proteolysis of the sigma factor RpoS by the Gac-Rsm signal transduction system in <i>Azotobacter vinelandii</i>. [PDF]

Microbiology (Reading)
Rojo-Rodríguez JB, Moreno S, Espin G.
europepmc   +1 more source