Results 101 to 110 of about 18,307 (208)

Protein degradation in bacteria: focus on the ClpP protease

Nippon Saikingaku Zasshi
Proteins in the cells are born (synthesized), work, and die (decomposed). In the life of a protein, its birth is obviously important, but how it dies is equally important in living organisms. Proteases secreted into the outside of cells are used to decompose the external proteins and the degradation products are taken as the nutrients.
Fumihiro, Ishikawa, Michio, Homma, Genzoh, Tanabe, Takayuki, Uchihashi   +3 more
openaire   +2 more sources

Mechanochemical basis of protein degradation by a double-ring AAA+ machine [PDF]

, 2014
Molecular machines containing double or single AAA+ rings power energy-dependent protein degradation and other critical cellular processes, including disaggregation and remodeling of macromolecular complexes.
A Martin, A Martin, A Roll-Mecak, Adrian O Olivares, AF Neuwald, Andrew R Nager, AR Nager, BM Stinson, C Zhao, CM Farrell, DA Dougan, DH Wolf, DM Smith, E Gur, E Gur, EM De La Cruz, EU Weber-Ban, F Guo, F Wang, J Hinnerwisch, J Liu, JA Kenniston, JC Cordova, JM Flynn, JM Miller, JW Kerssemakers, M Carrion-Vazquez, M Sen, MC Bewley, ME Aubin-Tam, ME Aubin-Tam, MR Maurizi, ND Werbeck, Ohad Iosefson, P Koodathingal, R Grimaud, RA Maillard, Robert T Sauer, RT Sauer, S Cranz-Mileva, SD Moore, SE Glynn, SM Doyle, T Ogura, Tania A Baker, W Kress, Y Katayama, YI Kim, Z Maglica   +48 more
core   +1 more source

Mechanism of allosteric activation in human mitochondrial ClpP protease

Proceedings of the National Academy of Sciences
AbstractHuman ClpP protease contributes to mitochondrial protein quality control by degrading misfolded proteins. ClpP is overexpressed in cancers such as acute myeloid leukemia (AML), where its inhibition leads to the accumulation of damaged respiratory chain subunits and cell death.
Monica M. Goncalves, Adwaith B. Uday, Taylor J. B. Forrester, S. Quinn W. Currie, Angelina S. Kim, Yue Feng, Yulia Jitkova, Algirdas Velyvis, Robert W. Harkness, Matthew S. Kimber, Aaron D. Schimmer, Natalie Zeytuni, Siavash Vahidi   +12 more
openaire   +2 more sources

A LON-ClpP Proteolytic Axis Degrades Complex I to Extinguish ROS Production in Depolarized Mitochondria [PDF]

, 2016
Mitochondrial dysfunction is implicated in numerous neurodegenerative disorders and in Parkinson’s disease (PD) in particular. PINK1 and Parkin gene mutations are causes of autosomal recessive PD, and these respective proteins function cooperatively to ...
Pryde, KR, Schapira, AH, Taanman, JW
core   +1 more source

Subunit asymmetry and roles of conformational switching in the hexameric AAA+ ring of ClpX [PDF]

, 2015
The hexameric AAA+ ring of Escherichia coli ClpX, an ATP-dependent machine for protein unfolding and translocation, functions with the ClpP peptidase to degrade target substrates.
A Martin, Benjamin M Stinson, BM Stinson, DM Smith, G Thibault, GC Lander, GL Hersch, I Chen, JA Kenniston, JA Kenniston, JC Cordova, JG Nørby, JJ Lavinder, JW Taraska, Karl R Schmitz, M Sen, M-E Aubin-Tam, ME Matyskiela, MW Popp, R Beckwith, RA Maillard, RE Burton, Robert T Sauer, RT Sauer, SA Joshi, SE Glynn, TA Baker, Tania A Baker, TP Geladopoulos, UA Wojtyra, Vladimir Baytshtok, YI Kim, YI Kim   +32 more
core   +2 more sources

Overstory and understory vegetation interact to alter soil community composition and activity [PDF]

, 2011
Aim: To test if there is an interactive effect between tree and understory species on the soil microbial community (SMC), community level physiological profiles (CLPP) and soil micro-fauna.
Dawson, Lorna A., Keith, Aidan M., Mitchell, Ruth Joy, Potts, Jackie M., Reid, Eileen, Ross, Jasmine   +5 more
core   +1 more source

Molecular insights into the dynamic modulation of bacterial ClpP function and oligomerization by peptidomimetic boronate compounds

Scientific Reports
Bacterial caseinolytic protease P subunit (ClpP) is important and vital for cell survival and infectivity. Recent publications describe and discuss the complex structure–function relationship of ClpP and its processive activity mediated by 14 catalytic ...
Bruno Alves França, Sven Falke, Holger Rohde, Christian Betzel   +3 more
doaj   +1 more source

A Note on the Dimension of the Projection Space in a Latent Factor Regression Model with Application to Business Cycle Classification [PDF]

In this paper it is shown that the number of latent factors in a multiple multivariate regression model need not be larger than the number of the response variables in order to achieve an optimal prediction.
Luebke, Karsten, Weihs, Claus
core  

Structural insights into the Clp protein degradation machinery

mBio
The Clp protease system is important for maintaining proteostasis in bacteria. It consists of ClpP serine proteases and an AAA+ Clp-ATPase such as ClpC1.
Xiaolong Xu, Yanhui Wang, Wei Huang, Danyang Li, Zixin Deng, Feng Long   +5 more
doaj   +1 more source

Omnipresent Maxwell’s demons orchestrate information management in living cells [PDF]

, 2019
The development of synthetic biology calls for accurate understanding of the critical functions that allow construction and operation of a living cell.
Danchin, Antoine, Gregory Boel, Olivier Danot, Victor de Lorenzo, Antoine Danchin   +1 more
core