Results 101 to 110 of about 13,300 (205)

Decoding GUN1 in plastid‐to‐nucleus signaling: what it doesn't, what it does, and why it matters

New Phytologist, Volume 251, Issue 1, Page 81-88, July 2026.
Publication history of plant GUN1 research. Summary Plastid‐to‐nucleus retrograde signaling coordinates nuclear gene expression with the developmental and physiological state of plastids. GENOMES UNCOUPLED 1 (GUN1), a chloroplast‐localized PPR‐SMR protein, remains a central yet poorly understood component of this network.
Marco Wendler, Dario Leister, Tatjana Kleine   +2 more
wiley   +1 more source

The Temporal Expression of Global Regulator Protein CsrA Is Dually Regulated by ClpP During the Biphasic Life Cycle of Legionella pneumophila

Frontiers in Microbiology, 2019
Legionella pneumophila, an environmental bacterium that parasitizes protozoa, is the causative pathogen of Legionnaires' disease. L. pneumophila adopts a distinct biphasic life cycle that allows it to adapt to environmental conditions for survival ...
Zhen-huang Ge, Zhen-huang Ge, Qin-sha Long, Qin-sha Long, Pei-bo Yuan, Pei-bo Yuan, Xin Pan, Dong Shen, Dong Shen, Yong-jun Lu, Yong-jun Lu   +10 more
doaj   +1 more source

Mitochondrial Enzymes Mimetic Ultrasmall Palladium Nanozymes Prevent Senescence and Neurodegeneration Through Metabolic Reprogramming

Advanced Science, Volume 13, Issue 32, 9 June 2026.
Simply constructed polyvinylpyrrolidone (PVP) modified palladium nanoparticles (PdP NPs) as cytochrome c oxidase (CcO) and superoxide dismutase (SOD) mimic are promising multifunctional nanoreactors to boost mitochondrial respiration chain function and refine homeostasis via regulation of mitochondrial dynamics and proteostasis sensor UPRmt, which ...
Wenshu Cong, Haiming Jing, Zinan Li, Wenjing Zhang, Nan Zhang, Yingqiu Xie, Shan Gao, Yuanyu Huang, Junyu Ning   +8 more
wiley   +1 more source

Molecular insights into the dynamic modulation of bacterial ClpP function and oligomerization by peptidomimetic boronate compounds

Scientific Reports
Bacterial caseinolytic protease P subunit (ClpP) is important and vital for cell survival and infectivity. Recent publications describe and discuss the complex structure–function relationship of ClpP and its processive activity mediated by 14 catalytic ...
Bruno Alves França, Sven Falke, Holger Rohde, Christian Betzel   +3 more
doaj   +1 more source

Spatial optimization of cultivated land protection policy implementation effect in China using a geographically optimal zones-based heterogeneity model

GIScience & Remote Sensing
Cultivated land protection policies (CLPP) are crucial for safeguarding China's food security and promoting sustainable agricultural development; however, their implementation is prone to deviations and divergence from intended objectives.
Yanwei Zhang, Ruixin Chen, Xinhai Lu, Houbao Fan, Li Wang, Bo Xia, Douglas Baker   +6 more
doaj   +1 more source

Mitochondrial Protease ClpP is a Target for the Anticancer Compounds ONC201 and Related Analogues

ACS Chemical Biology, 2019
ONC201 is a first-in-class imipridone molecule currently in clinical trials for the treatment of multiple cancers. Despite enormous clinical potential, the mechanism of action is controversial.
P. Graves, Lucas J. Aponte-Collazo, E. Fennell, Adam C Graves, Andrew E. Hale, Nedyalka N Dicheva, Laura E. Herring, T. S. Gilbert, Michael P. East, Ian M. McDonald, Matthew R. Lockett, H. Ashamalla, Nathaniel J. Moorman, D. Karanewsky, E. Iwanowicz, E. Holmuhamedov, L. Graves   +16 more
semanticscholar   +1 more source

ClpP: A distinctive family of cylindrical energy‐dependent serine proteases

FEBS Letters, 2007
Processes maintaining protein homeostasis in the cell are governed by the activities of molecular chaperones that mainly assist in the folding of polypeptide chains and by a large class of proteases that regulate protein levels through degradation. ClpP proteases define a distinctive family of cylindrical, energy‐dependent serine proteases that are ...
Yu, Angela Yeou Hsiung, Houry, Walid A.
openaire   +2 more sources

Structural insights into the Clp protein degradation machinery

mBio
The Clp protease system is important for maintaining proteostasis in bacteria. It consists of ClpP serine proteases and an AAA+ Clp-ATPase such as ClpC1.
Xiaolong Xu, Yanhui Wang, Wei Huang, Danyang Li, Zixin Deng, Feng Long   +5 more
doaj   +1 more source

Discovery of coniferaldehyde as an inhibitor of caseinolytic protease to combat Staphylococcus aureus infections

Molecular Medicine
The rising incidence of methicillin-resistant Staphylococcus aureus (MRSA) poses a significant threat to global public health, highlighting the urgent need for novel therapies and treatments in clinical settings.
Shufang Li, Yan Zhang, Jianfeng Wang, Hongfa Lv, Hongxia Ma, Lingcong Kong, Yonglin Zhou, Jingmin Gu, Wei Li, Qiaoling Zhang   +9 more
doaj   +1 more source

Harmaline to Human Mitochondrial Caseinolytic Serine Protease Activation for Pediatric Diffuse Intrinsic Pontine Glioma Treatment

Pharmaceuticals
Diffuse intrinsic pontine glioma (DIPG), affecting children aged 4–7 years, is a rare, aggressive tumor that originates in the pons and then spreads to nearby tissue.
Morena Miciaccia, Francesca Rizzo, Antonella Centonze, Gianfranco Cavallaro, Marialessandra Contino, Domenico Armenise, Olga Maria Baldelli, Roberta Solidoro, Savina Ferorelli, Pasquale Scarcia, Gennaro Agrimi, Veronica Zingales, Elisa Cimetta, Simone Ronsisvalle, Federica Maria Sipala, Paola Loguercio Polosa, Cosimo Gianluca Fortuna, Maria Grazia Perrone, Antonio Scilimati   +18 more
doaj   +1 more source