Results 101 to 110 of about 13,032 (201)

Regulation of adipose tissue biology by mitochondrial protease CLPP [PDF]

Mitochondrien sind für die Aufrechterhaltung der zellulären Homöostase und die Orchestrierung von Signal-, Stoffwechsel- und Energieströmen von wesentlicher Bedeutung.
Kaul, Harshita
core  

Trapping and proteomic identification of cellular substrates of the ClpP protease in Staphylococcus aureus

, 2013
In the important human pathogen Staphylococcus aureus the cytoplasmic ClpP protease is essential for mounting cellular stress responses and for virulence.
Lotte Jelsbak, Stefanie Krieger, Julie H. Andersen, Dorte Frees, Anders N. Varming, Dirk Albrecht, Knut Ohlsen, Michael Hecker, Ohlsen, Knut, Hecker, Michael, Hanne Ingmer, Albrecht, Dirk, Jelsbak, Lotte, Ulf Gerth, Ingmer, Hanne, Jingyuan Feng, Krieger, Stefanie, Feng, Jingyuan, Frees, Dorte, Andersen, Julie H., Gerth, Ulf, Stephan Michalik, Michalik, Stephan, Varming, Anders Nissen   +23 more
core   +1 more source

Mitochondrial Unfolded Protein Response Gene Clpp Is Required for Oocyte Function and Female Fertility

Mitochondrial unfolded protein stress response (mtUPR) plays a critical role in regulating cellular and metabolic stress response and helps maintain protein homeostasis.
Mauro Cozzolino, Murat Basar, Cem Demirkiran, Raziye Melike Yildirim, Yagmur Ergun, Aysegul Gizem Imamoglu, Akanksha Garg, Emre Seli   +7 more
core   +1 more source

DESIGN AND SYNTHESIS OF NEW CLPP ACTIVATORS: TOWARDS THE DEVELOPMENT OF A COMPUTATIONALLY GUIDED APPROACH [PDF]

, 2016
With the rise of antibiotic-resistant bacteria, there is an urgent need to develop antibacterials with new mechanisms of action. Because of its essential role in bacterial survival and the possibility to induce unselective substrate degradation via ...
Avila, Quentin P.
core  

Struktur, Funktion und Inhibition von ClpP-Proteasen

, 2016
This work covers three main aspects of ClpP proteases: (i) Structural analysis of ClpP from pathogenic Staphylococcus aureus uncovered a regulator switch preventing uncontrolled proteolysis.
Gersch, Malte
core  

Structural insights into the Clp protein degradation machinery

mBio
The Clp protease system is important for maintaining proteostasis in bacteria. It consists of ClpP serine proteases and an AAA+ Clp-ATPase such as ClpC1.
Xiaolong Xu, Yanhui Wang, Wei Huang, Danyang Li, Zixin Deng, Feng Long   +5 more
doaj   +1 more source

Antibodies against homologous microbial caseinolytic proteases P (ClpP) characterise primary biliary cirrhosis.

, 2001
Background/Aims: Antibodies to caseinolytic protease P177-194 (ClpP(177-194)) of the proteolytic subunit of the Clp complex of Escherichia coli (E. coli) are uniquely present in primary biliary cirrhosis (PBC).
Vergani, D, Sharma, U C, Burroughs, A K, Grasso, A, Ma, Y, Baum, H, Bogdanos, D P   +6 more
core   +1 more source

Discovery of coniferaldehyde as an inhibitor of caseinolytic protease to combat Staphylococcus aureus infections

Molecular Medicine
The rising incidence of methicillin-resistant Staphylococcus aureus (MRSA) poses a significant threat to global public health, highlighting the urgent need for novel therapies and treatments in clinical settings.
Shufang Li, Yan Zhang, Jianfeng Wang, Hongfa Lv, Hongxia Ma, Lingcong Kong, Yonglin Zhou, Jingmin Gu, Wei Li, Qiaoling Zhang   +9 more
doaj   +1 more source

The ClpP protease of Streptococcus pneumoniae modulates virulence gene expression and protects against fatal pneumococcal challenge

, 2004
Copyright © 2004, American Society for Microbiology.Streptococcus pneumoniae usually colonizes the nasopharynx of humans asymptomatically but occasionally translocates from this niche to the lungs, the brain, and the blood, causing potentially fatal ...
Rhee, D., Choi, M., Pyo, S., Ogunniyi, A., Paton, J., Kwon, H.   +5 more
core   +1 more source

Harmaline to Human Mitochondrial Caseinolytic Serine Protease Activation for Pediatric Diffuse Intrinsic Pontine Glioma Treatment

Pharmaceuticals
Diffuse intrinsic pontine glioma (DIPG), affecting children aged 4–7 years, is a rare, aggressive tumor that originates in the pons and then spreads to nearby tissue.
Morena Miciaccia, Francesca Rizzo, Antonella Centonze, Gianfranco Cavallaro, Marialessandra Contino, Domenico Armenise, Olga Maria Baldelli, Roberta Solidoro, Savina Ferorelli, Pasquale Scarcia, Gennaro Agrimi, Veronica Zingales, Elisa Cimetta, Simone Ronsisvalle, Federica Maria Sipala, Paola Loguercio Polosa, Cosimo Gianluca Fortuna, Maria Grazia Perrone, Antonio Scilimati   +18 more
doaj   +1 more source