Results 171 to 180 of about 13,300 (205)

The regulation of Porphyromonas gingivalis biofilm formation by ClpP

Biochemical and Biophysical Research Communications, 2019
Porphyromonas gingivalis is one of the most commonly detected pathogens in periodontal disease and root canal infections. Its viability and pathogenicity are greatly increased in plaque biofilms. Some caseinolytic proteases (Clp) reportedly regulate biofilm formation by various pathogenic bacteria, including P. gingivalis.
Lu, He, Hongyuan, Wang, Ru, Zhang, Hong, Li   +3 more
openaire   +2 more sources

Mitochondrial protease ClpP supplementation ameliorates diet-induced NASH in mice.

Journal of Hepatology, 2022
BACKGROUND & AIMS Mitochondrial dysfunction is considered a pathogenic linker in the development of non-alcoholic steatohepatitis (NASH). Inappropriate mitochondrial protein-quality control, possibly induced due to insufficiency of the mitochondrial ...
Sung-E Choi, Y. Hwang, S. Lee, Hyunkyung Jung, T. Shin, Y. Son, Seo-Ye Park, S. Han, H. Kim, K. Lee, Gwang Lee, J. Kemper, H. Song, Yup Kang   +13 more
semanticscholar   +1 more source

The Role of ClpP in Protein Expression of Streptococcus pneumoniae

Current Microbiology, 2011
Previous reports suggest that ClpP proteolytic activity is important not only for cell physiology but also for regulation of virulence properties of Streptococcus pneumoniae (S. pneumoniae). In order to get a more comprehensive picture of the role of ClpP protease on protein expression in S. pneumoniae D39 and how it relates to physiology and virulence,
Qun, Zhang, Yuanshuai, Huang, Hong, Wang, Wenchun, Xu, Lan, Liu, Yibing, Yin, Xuemei, Zhang   +6 more
openaire   +2 more sources

The activated ClpP peptidase forcefully grips a protein substrate

Biophysical Journal, 2022
ATPases associated with diverse cellular activities (AAA+) proteases power the maintenance of protein homeostasis by coupling ATP hydrolysis to mechanical protein unfolding, translocation, and ultimately degradation. Although ATPase activity drives a large portion of the mechanical work these molecular machines perform, how the peptidase contributes to
Steven D, Walker, Adrian O, Olivares
openaire   +2 more sources

Harnessing the Magic Methyl Effect: Discovery of CLPP-2068 as a Novel HsClpP Activator for the Treatment of Diffuse Large B-Cell Lymphoma.

Journal of Medicinal Chemistry
The "magic methyl effect" has facilitated the successful development of numerous pharmaceutical compounds. During the development of HsClpP activators, we found that incorporating methyl groups into the bicyclic imipridone scaffolds significantly ...
Mingyang Sun, Beijing Chen, Dan Teng, Hong-Su Zhao, Yilie Liao, Chun Zhang, Qi Huang, Huicong Ma, Chongyu Wang, Xinyi Lin, Peng-Cheng Yu, Qingning Yuan, Jinghua Yu, Lei Xu, Xiaobei Hu, Fei Ye, Xingxing Diao, Mingyue Zheng, Wanchao Yin, Yubo Zhou, Jia Li, Mingliang Wang   +21 more
semanticscholar   +1 more source

Structure-Guided Development of ClpP Agonists with Potent Therapeutic Activities against Staphylococcus aureus Infection.

Journal of Medicinal Chemistry
Peritonitis caused by Staphylococcus aureus poses a severe threat to patients with end-stage renal failure. Treating multidrug-resistant S. aureus infections requires the use of antibiotics with diverse mechanisms of action. Caseinolytic protease P (ClpP)
Tao Zhang, Wei Wu, Yanling Zhao, Z. Ding, Bingyan Wei, Teng Yang, Jiahui Li, Pengyu Wang, Lefu Lan, J. Gan, Cai-guang Yang   +10 more
semanticscholar   +1 more source

The mitochondrial protease ClpP is a promising target for multiple myeloma treatment.

Biochemical Pharmacology
Drug resistance and relapse are the major obstacles in multiple myeloma (MM) treatment, driving the search for novel therapeutics. The chemoactivation of mitochondrial caseinolytic protease P (ClpP) has shown to have anticancer effects on many tumors ...
Xiang Liu, Jinlong Gu, Song Liu, Jingcao Huang, Linfeng Li, Fangfang Wang, Siyao He, Ziyue Mi, Yue Zhang, Jingjing Wen, Qianwen Gao, Haonan Yang, Yu Feng, Hongmei Luo, Xinyu Zhai, Li Zhang, Yuhuan Zheng, Youfu Luo, Ting Niu   +18 more
semanticscholar   +1 more source

Selective Activation of Human Caseinolytic Protease P (ClpP)

Angewandte Chemie - International Edition, 2018
AbstractCaseinolytic protease P (ClpP) is the proteolytic component of the ClpXP protein degradation complex. Eukaryotic ClpP was recently found to act within the mitochondria‐specific unfolded protein response (UPRmt). However, its detailed function and dedicated regulation remain largely unexplored.
Leonhard M Kick, Matthias Stahl, Klaus Richter   +2 more
exaly   +3 more sources

IMP075 targeting ClpP for colon cancer therapy in vivo and in vitro.

Biochemical Pharmacology, 2022
ONC201 is a well-known caseinolytic protease (ClpP)activator with established benefits against multiple tumors, including colorectal cancer (CRC). In this study, we investigated the anticancer effects and associated mechanisms of the ClpP agonist IMP075,
Jiangnan Zhang, Baozhu Luo, Jing Sui, Zhiqiang Qiu, Jiasheng Huang, Tao Yang, Youfu Luo   +6 more
semanticscholar   +1 more source

ClpP: A structurally dynamic protease regulated by AAA+ proteins

Journal of Structural Biology, 2012
Proteolysis is an important process for many aspects of bacterial physiology. Clp proteases carry out a large proportion of protein degradation in bacteria. These enzymes assemble in complexes that combine the protease ClpP and the unfoldase, ClpA or ClpX.
John A, Alexopoulos, Alba, Guarné, Joaquin, Ortega   +2 more
openaire   +2 more sources