Results 181 to 190 of about 13,300 (205)

The Structural Basis for the Activation and Peptide Recognition of Bacterial ClpP

Journal of Molecular Biology, 2008
ClpP and its ATPase compartment, ClpX or ClpA, remove misfolded proteins in cells and are of utmost importance in protein quality control. The ring hexamers of ClpA or ClpX recognize, unfold, and translocate target substrates into the degradation chamber of the double-ring tetradecamer of ClpP.
Dong Young, Kim, Kyeong Kyu, Kim
openaire   +2 more sources

Characterization of mouse Clpp protease cDNA, gene, and protein

Mammalian Genome, 2000
Mutations that cause accumulation or rapid degradation owing to protein misfolding are a frequent cause of inherited disease in humans. In Escherichia coli, Clpp protease is one of the components of the protein quality control system that handles misfolded proteins.
Andresen, B S, Corydon, T J; id_orcid 0000-0003-3588-6350, Wilsbech, M, Bross, P; id_orcid 0000-0001-9526-8525, Hindkjaer, T F, Bolund, L, Gregersen, N, Schroeder, L D   +7 more
openaire   +3 more sources

Role of ClpP in biofilm formation and virulence of Staphylococcus epidermidis

Microbes and Infection, 2007
Infections caused by the leading nosocomial pathogen Staphylococcus epidermidis are characterized by biofilm formation on implanted medical devices. However, the molecular basis of biofilm formation and its regulation are not completely understood.
Chongzhen, Wang, Min, Li, Dandan, Dong, Jianping, Wang, Jun, Ren, Michael, Otto, Qian, Gao   +6 more
openaire   +2 more sources

The development of small-molecule modulators for ClpP protease activity

Molecular BioSystems, 2016
Abstract The global spread of antibiotic resistance among important human pathogens emphasizes the need to find new antibacterial drugs with a novel mode of action. The ClpP protease has been shown to demonstrate its pivotal importance to both the survival and the virulence of pathogenic bacteria during host infection.
Fei, Ye, Jiahui, Li, Cai-Guang, Yang
openaire   +2 more sources

Bioinformatic evaluation of ClpP as a vaccine target in Streptococcus pneumoniae

Biotechnology Letters
To conduct a comprehensive bioinformatic analysis to assess the immunogenicity and conservation profiles of ClpP in Streptococcus pneumoniae, thereby verifying its feasibility as a candidate vaccine target.The nucleotide and amino acid sequences of the clpP gene were obtained from the NCBI database.
Yanying Huang, Liyan Zhu, Weihua Li, Shilei Dong   +3 more
openaire   +2 more sources

The Role of ClpP Protease in Bacterial Pathogenesis and Human Diseases

ACS Chemical Biology, 2018
In prokaryotic cells and eukaryotic organelles, the ClpP protease plays an important role in proteostasis. The disruption of the ClpP function has been shown to influence the infectivity and virulence of a number of bacterial pathogens. More recently, ClpP has been found to be involved in various forms of carcinomas and in Perrault syndrome, which is ...
Vaibhav Bhandari, Keith S. Wong, Jin Lin Zhou, Mark F. Mabanglo, Robert A. Batey, Walid A. Houry   +5 more
openaire   +2 more sources

Potent ClpP agonists with anticancer properties bind with improved structural complementarity and alter the mitochondrial N-terminome

Structure, 2023
Walid Houry, Elisa Leung, Mark F Mabanglo   +2 more
exaly  

Substrates and interactors of the ClpP protease in the mitochondria

Current Opinion in Chemical Biology, 2022
Walid Houry, Vaibhav Bhandari, Mark F Mabanglo   +2 more
exaly  

ClpP: a new Achilles' heel in myeloma

Blood
Antonio Sacco, Aldo M. Roccaro
openaire   +2 more sources

Assessing CLPPs using MicroResp™

Journal of Soils and Sediments, 2007
Stephen J. Chapman, Colin D. Campbell, Rebekka R. E. Artz   +2 more
openaire   +1 more source