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Bioinformatic evaluation of ClpP as a vaccine target in Streptococcus pneumoniae
Biotechnology LettersTo conduct a comprehensive bioinformatic analysis to assess the immunogenicity and conservation profiles of ClpP in Streptococcus pneumoniae, thereby verifying its feasibility as a candidate vaccine target.The nucleotide and amino acid sequences of the clpP gene were obtained from the NCBI database.
Yanying Huang +3 more
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Patenting perspective of modulators of ClpP endopeptidase: 2019-present
Expert Opinion on Therapeutic PatentsClpP is a highly conserved serine protease that plays a crucial role in maintaining protein homeostasis in both bacterial cells and human mitochondria. Several studies have demonstrated the potential of ClpP as a drug target, with ClpP modulators, including both inhibitors and activators, showing promise in treating a range of conditions such as drug ...
Zhenyu, Wang +3 more
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ClpP Peptidase as a Plausible Target for the Discovery of Novel Antibiotics
Current Drug TargetsAbstract: Antimicrobial resistance (AMR) to currently available antibiotics/drugs is a global threat. It is desirable to develop new drugs that work through a novel target(s) to avoid drug resistance. This review discusses the potential of the caseinolytic protease P (ClpP) peptidase complex as a novel target for finding novel antibiotics, emphasising
Smriti Bhardwaj, Kuldeep K. Roy
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Assessing CLPPs using MicroResp™
Journal of Soils and Sediments, 2007Stephen J. Chapman +2 more
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Mitochondrial ClpP-Mediated Proteolysis Induces Selective Cancer Cell Lethality
Cancer Cell, 2019Samir H Barghout +2 more
exaly
The Antibiotic ADEP Reprogrammes ClpP, Switching It From a Regulated to an Uncontrolled Protease
EMBO Molecular Medicine, 2009Heike Brötz-Oesterhelt +2 more
exaly