Results 71 to 80 of about 10,075 (175)

Chemical Activators of ClpP: Turning Jekyll into Hyde

Chemistry & Biology, 2011
Casein lytic peptidase P (ClpP) is a serine peptidase that, when coupled to its cognate ATPase, facilitates the controlled degradation of both damaged and unwanted proteins in bacteria. In this issue of Chemistry & Biology, Leung et al. (2011) report a small molecule screen against ClpP, from which they identified four structurally distinct compounds ...
openaire   +2 more sources

Complete Chloroplast Genomes of Ranunculus arvensis and Ranunculus laetus: Comparative Analysis and Phylogenetic Insights

Ecology and Evolution, Volume 16, Issue 5, May 2026.
Here, we de novo assembled the chloroplast genomes of Ranunculus arvensis and Ranunculus laetus, providing comprehensive comparative analysis with 21 congeners. The genomes exhibited conserved quadripartite structures with no major rearrangements, though lineage‐specific variations in atpH position were detected in two species.
Hui Li, Siyue Zhang, Abdullah, Sayed Afzal Shah, Yuhua Huang, Jingjing Jia, Liya Guo, Ying Cui, Jiahui Sun, Parviz Heidari, Xiaoxuan Tian   +10 more
wiley   +1 more source

Comparative Chloroplast Genomics of Cousinia (Asteraceae) With Nine Newly Sequenced Endemic Species From Central Asia

Ecology and Evolution, Volume 16, Issue 5, May 2026.
In this study, nine complete chloroplast genomes of Cousinia species endemic to the Pamir–Alay mountain system were sequenced and analyzed together with previously published plastomes and nuclear ribosomal ITS data. ABSTRACT Cousinia (Asteraceae: Cardueae) represents one of the most species‐rich genera within the Irano–Turanian floristic region, yet ...
Bobur Karimov, Diyorjon Hamrayev, Husniddin Esanov, Alijon Eshonkulov, Oybek Omonov, Nodira Boboyeva, Damira Karimova, Abdullajon Umedov, Temur Asatulloev, Ziyoviddin Yusupov, Komiljon Sh. Tojibaev   +10 more
wiley   +1 more source

Chloroplast Phylogenomics and Barcode Discovery in Medicinal Stachys Species Reveal Evolutionary Relationships and Adaptive Signatures

Ecology and Evolution, Volume 16, Issue 5, May 2026.
This study presents the first complete chloroplast genomes of two medicinally important Stachys species, S. persica and S. germanica. Comparative phylogenomic analyses revealed highly conserved genomes with lineage‐specific variations, identified hypervariable regions as candidate DNA barcodes, and detected signatures of positive selection in the petB ...
Fatemeh Sadat Ghotbi, Aboozar Soorni
wiley   +1 more source

Discovery of CLPP-1071 as an Exceptionally Potent and Orally Efficacious Human ClpP Activator with Strong In Vivo Antitumor Activity

Journal of Medicinal Chemistry
Human sapiens caseinolytic protease P (ClpP) is essential for maintaining mitochondrial proteome homeostasis, and its activation is increasingly recognized as a promising cancer therapy strategy. Herein, based on structure-guided drug design, we discovered a series of potent ClpP activators by introducing a methyl group to the imipridone scaffold of ...
Beijing Chen, Mingyang Sun, Chun Zhang, Qi Huang, Dan Teng, Linghao Hu, Huicong Ma, Xinyi Lin, Zan Huang, Renzhao Gui, Xiaobei Hu, Lei Xu, Mingyue Zheng, Yubo Zhou, Jia Li, Mingliang Wang   +15 more
openaire   +2 more sources

The Temporal Expression of Global Regulator Protein CsrA Is Dually Regulated by ClpP During the Biphasic Life Cycle of Legionella pneumophila

Frontiers in Microbiology, 2019
Legionella pneumophila, an environmental bacterium that parasitizes protozoa, is the causative pathogen of Legionnaires' disease. L. pneumophila adopts a distinct biphasic life cycle that allows it to adapt to environmental conditions for survival ...
Zhen-huang Ge, Zhen-huang Ge, Qin-sha Long, Qin-sha Long, Pei-bo Yuan, Pei-bo Yuan, Xin Pan, Dong Shen, Dong Shen, Yong-jun Lu, Yong-jun Lu   +10 more
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Identifying Subcellular Structure Components in Escherichia Coli by Crosslinking and SEC‐MS

PROTEOMICS, Volume 26, Issue 5, Page 27-36, May 2026.
ABSTRACT Cells are comprised of a broad spectrum of structures that compartmentalize biochemical and signaling mechanisms. These structures can be comprised of many biomolecules, but especially lipids, proteins, and nucleic acids. Techniques are limited to quantify or discover new subcellular structures.
Rachel A. Victor, Austin Lipinski, Paul R. Langlais, Jacob C. Schwartz   +3 more
wiley   +1 more source

Quality control of protein import into mammalian mitochondria

Protein Science, Volume 35, Issue 5, May 2026.
Abstract Mitochondrial function depends on the continuous import of hundreds of nuclear‐encoded proteins. Targeting and translocation of mitochondrial proteins is a multistep process that is inherently vulnerable to defects in cytosolic quality control systems as well as perturbations in mitochondrial protein import machinery and organelle function ...
Madeleine Goldstein, Laurie Lee‐Glover, Hilla Weidberg   +2 more
wiley   +1 more source

ClpP: A distinctive family of cylindrical energy‐dependent serine proteases

FEBS Letters, 2007
Processes maintaining protein homeostasis in the cell are governed by the activities of molecular chaperones that mainly assist in the folding of polypeptide chains and by a large class of proteases that regulate protein levels through degradation. ClpP proteases define a distinctive family of cylindrical, energy‐dependent serine proteases that are ...
Yu, Angela Yeou Hsiung, Houry, Walid A.
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Molecular insights into the dynamic modulation of bacterial ClpP function and oligomerization by peptidomimetic boronate compounds

Scientific Reports
Bacterial caseinolytic protease P subunit (ClpP) is important and vital for cell survival and infectivity. Recent publications describe and discuss the complex structure–function relationship of ClpP and its processive activity mediated by 14 catalytic ...
Bruno Alves França, Sven Falke, Holger Rohde, Christian Betzel   +3 more
doaj   +1 more source