Results 71 to 80 of about 13,300 (205)

Cancer pain: current practice and emerging targets

British Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye, Marcin Chwistek, Zhiting Gong, Vanessa Uzonwanne, Xiaojie Shi, Arpad Szallasi   +5 more
wiley   +1 more source

Molybdopterin biosynthesis pathway contributes to the regulation of SaeRS two-component system by ClpP in Staphylococcus aureus

Virulence, 2022
In Staphylococcus aureus, the SaeRS two-component system is essential for the bacterium’s hemolytic activity and virulence. The Newman strain of S. aureus contains a variant of SaeS sensor kinase, SaeS L18P.
Na Zhao, Yanan Wang, Junlan Liu, Ziyu Yang, Ying Jian, Hua Wang, Mahmoud Ahmed, Min Li, Taeok Bae, Qian Liu   +9 more
doaj   +1 more source

Knockout Mouse Studies Show That Mitochondrial CLPP Peptidase and CLPX Unfoldase Act in Matrix Condensates near IMM, as Fast Stress Response in Protein Assemblies for Transcript Processing, Translation, and Heme Production

Genes
LONP1 is the principal AAA+ unfoldase and bulk protease in the mitochondrial matrix, so its deletion causes embryonic lethality. The AAA+ unfoldase CLPX and the peptidase CLPP also act in the matrix, especially during stress periods, but their substrates
J. Key, S. Gispert, Georg Auburger
semanticscholar   +1 more source

Mitochondrial Matrix Protease ClpP Agonists Inhibit Cancer Stem Cell Function in Breast Cancer Cells by Disrupting Mitochondrial Homeostasis

bioRxiv, 2022
Mitochondria are multifaceted organelles which are important for bioenergetics, biosynthesis and signaling in metazoans. Mitochondrial functions are frequently altered in cancer to promote both the energy and the necessary metabolic intermediates for ...
Y. Greer, L. Hernandez, E. Fennell, D. Voeller, R. Chari, Samuel F Gilbert, Binwu Tang, Markus Hafner, C. Annunziata, E. Iwanowicz, L. Graves, S. Lipkowitz   +11 more
semanticscholar   +1 more source

Dissection of Mitochondrial Function via Chemical Perturbation and Single‐Cell Profiling

Cell Proliferation, EarlyView.
We establish a systematic framework to dissect mitochondrial function at the module level by combining targeted chemical perturbations with scRNA‐seq. This approach reveals shared and module‐specific programs linking mitochondrial activity to mito‐nuclear communication, stress response, and cell cycle, highlighting the tight coupling between ...
Hao Luo, Xiaona Yin, Hongxin He, Yaning Wang, Hongbo Zhang   +4 more
wiley   +1 more source

The Bacterial ClpXP-ClpB Family Is Enriched with RNA-Binding Protein Complexes

Cells, 2022
In the matrix of bacteria/mitochondria/chloroplasts, Lon acts as the degradation machine for soluble proteins. In stress periods, however, proteostasis and survival depend on the strongly conserved Clp/Hsp100 family. Currently, the targets of ATP-powered
Georg Auburger, Jana Key, Suzana Gispert
doaj   +1 more source

Placental mitochondrial metabolic adaptation maintains cellular energy balance in pregnancy complicated by gestational hypoxia

The Journal of Physiology, EarlyView.
Abstract figure legend Placental mitochondrial adaptation to gestational hypoxia. Hypoxic pregnancy in sheep increases placental insulin like growth factor 2 (IGF2) signalling (1), which is associated with a shift in capacity away from β‐oxidation (2) and complex I‐mediated respiration (3), while maintaining total oxidative phosphorylation capacity (4).
Wen Tong, Beth J. Allison, Kirsty L. Brain, Olga V. Patey, Youguo Niu, Kimberley J. Botting, Sage G. Ford, Tess A. Garrud, Peter F. B. Wooding, Qiang Lyu, Lin Zhang, Jin Ma, Alice P. Sowton, Katie A. O'Brien, Tereza Cindrova‐Davies, Hong Wa Yung, Graham J. Burton, Andrew J. Murray, Dino A. Giussani   +18 more
wiley   +1 more source

Purification of the Caseinolytic protease ClpP.

, 2022
The caseinolytic protease P (ClpP) is an essential protein for bacteria and bacterial derived organelles. It belongs to the AAA+ family of proteases and has proteolytic activity, thereby, it plays an important role in protein digestion. This protease is involved in essential processes such as, cellular regulatory mechanisms, protein homeostasis ...
Pedrós Manzanares, Laura, Brötz-Oesterhelt, Heike   +1 more
openaire   +1 more source

Mitochondrial Unfolded Protein Response Gene Clpp Is Required for Oocyte Function and Female Fertility

International Journal of Molecular Sciences
Mitochondrial unfolded protein stress response (mtUPR) plays a critical role in regulating cellular and metabolic stress response and helps maintain protein homeostasis.
Yagmur Ergun, Aysegul Gizem Imamoglu, M. Cozzolino, Cem Demirkiran, Murat Başar, A. Garg, R. M. Yildirim, E. Seli   +7 more
semanticscholar   +1 more source

Phylogenetics of Clusia sect. Criuva (Clusiaceae) unveils a new species, reinstates an old name and clarifies sectional circumscription

TAXON, Volume 75, Issue 4, August 2026.
Abstract Clusia sect. Criuva has long been a taxonomic catch‐all, particularly in the final decades of the 20th century, when misapplications conflated eastern Brazilian taxa with species from the Guiana Shield. We combine herbarium‐based genome skimming, targeted fieldwork, and critical examination of historical literature and types to reassess ...
José E. do Nascimento Jr, Volker Bittrich, Maria do Carmo Estanislau do Amaral   +2 more
wiley   +1 more source