Results 21 to 30 of about 13,032 (201)

Metabolic Perturbations in a Bacillus subtilis clpP Mutant during Glucose Starvation [PDF]

Metabolites, 2017
Proteolysis is essential for all living organisms to maintain the protein homeostasis and to adapt to changing environmental conditions. ClpP is the main protease in Bacillus subtilis, and forms complexes with different Clp ATPases.
Daniel Schultz, Rabea Schlüter, Ulf Gerth, Michael Lalk   +3 more
doaj   +2 more sources

Allosteric inhibition of human mitochondrial ClpP by hijacking the dordaviprone (ONC201) binding site [PDF]

Nature Communications
ClpP protease maintains proteostasis in human mitochondria and is overexpressed in cancers such as acute myeloid leukemia (AML). While activators such as dordaviprone (ONC201) have reached the clinic, the development of ClpP inhibitors has been hampered ...
Monica M. Goncalves, Adwaith B. Uday, Iain D. G. Watson, Anh M. Chau, Shiva Kalhor-Monfared, Benson Wan, Taira Kiyota, S. Quinn W. Currie, Yulia Jitkova, Yue Feng, Matthew Diamandas, Dakai Ling, Mary Ma, Ross S. Mancini, Zhezhou Wang, Matias Casás-Selves, Dhananjay Joshi, Mohammed Mohammed, Ratheesh Subramaniam, Evelyne Lima Fernandes, Yongran Yan, Neil Pomroy, Rose Hurren, Marcela Gronda, Algirdas Velyvis, Andrei K. Yudin, Mark A. Reed, Gil Prive, Ahmed Aman, Methvin Isaac, Richard Marcellus, David Uehling, Aaron D. Schimmer, Natalie Zeytuni, Siavash Vahidi   +34 more
doaj   +2 more sources

The ClpP protease homologue is required for the transmission traits and cell division of the pathogen Legionella pneumophila [PDF]

BMC Microbiology, 2010
Background Legionella pneumophila, the intracellular bacterial pathogen that causes Legionnaires' disease, exhibit characteristic transmission traits such as elevated stress tolerance, shortened length and virulence during the transition from the ...
Zhang Qin-fen, Zheng Xiao-cong, Gao Ye, Zeng Yong-lun, Li Xiang-hui, Zhou Shi-ning, Lu Yong-jun   +6 more
doaj   +2 more sources

Mode of action guided metagenomic natural product discovery reveals convergent evolution of a ClpP-targeting motif [PDF]

Nature Communications
The discovery of natural products with specific modes of action from metagenomes remains challenging. Here, we present resistance-CONKAT-seq, a pipeline that links biosynthetic gene clusters (BGCs) to self-resistance genes, enabling identification of ...
Jingbo Kan, Kaylyn Spotton, Adrian Morales-Amador, Yozen Hernandez, Ján Burian, Cecilia Panfil, Melinda A. Ternei, Robert E. Boer, Abir Bhattacharjee, Sean F. Brady   +9 more
doaj   +2 more sources

The cryo-EM structure of the chloroplast ClpP complex [PDF]

Nature Plants, 2021
Protein homoeostasis in plastids is strategically regulated by the protein quality control system involving multiple chaperones and proteases, among them the Clp protease. Here, we determined the structure of the chloroplast ClpP complex from Chlamydomonas reinhardtii by cryo-electron microscopy. ClpP contains two heptameric catalytic rings without any
Wang, Ning, Wang, Yifan, Zhao, Qian, Zhang, Xiang, Peng, Chao, Zhang, Wenjuan, Liu, Yanan, Vallon, Olivier, Schroda, Michael, Cong, Yao, Liu, Cuimin   +10 more
openaire   +3 more sources

Turned on for degradation: ATPase-independent degradation by ClpP [PDF]

Journal of Structural Biology, 2009
Clp is a barrel-shaped hetero-oligomeric ATP-dependent protease comprising a hexameric ATPase (ClpX or ClpA) that unfolds protein substrates and translocates them into the central chamber of the tetradecameric proteolytic component (ClpP) where they are degraded processively to short peptides. Chamber access is controlled by the N-terminal 20 residues (
Maria C, Bewley, Vito, Graziano, Kathleen, Griffin, John M, Flanagan   +3 more
openaire   +2 more sources

Regulation of cyclic lipopeptide biosynthesis in Pseudomonas fluorescens by the ClpP protease [PDF]

, 2009
Cyclic lipopeptides produced by Pseudomonas species exhibit potent surfactant and broad-spectrum antibiotic properties. Their biosynthesis is governed by large multimodular nonribosomal peptide synthetases, but little is known about the genetic ...
Bruijn, I., de, Raaijmakers, J.M.
core   +1 more source

CLPX and CLPP proteins are required for regulation of ALAS2

, 2021
Yien, YvetteHeme synthesis consists of a series of eight enzymatic steps that result in the synthesis of porphyrin products, which in turn can be used to generate other tetrapyrrole compounds.
Carter, Stashauna S.
core   +1 more source

Complementation studies with human ClpP in Bacillus subtilis

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2020
ATP-dependent intracellular proteolysis is essential for all living organisms. ClpP, the proteolytic subunit of the ATP-dependent Clp proteases, shares 56% protein identity between B. subtilis and man. The aim of this study was to verify, whether human ClpP (HClpP) is able to substitute the bacterial pendant, BClpP, irrespectively of the huge ...
Denise, Dittmar, Alexander, Reder, Rabea, Schlüter, Katharina, Riedel, Michael, Hecker, Ulf, Gerth   +5 more
openaire   +2 more sources

Mitochondrial protease ClpP supplementation ameliorates diet-induced NASH in mice

, 2022
BACKGROUND & AIMS: Mitochondrial dysfunction is considered a pathogenic linker in the development of non-alcoholic steatohepatitis (NASH). Inappropriate mitochondrial protein-quality control, possibly induced by insufficiency of the mitochondrial matrix ...
Lee, SJ, Jung, H, Kang, Y, Son, Y, Park, S, Song, HK, Hwang, Y, Han, SJ, Lee, G, Kemper, JK, Kim, HJ, Choi, SE, Lee, KW, Shin, TH, Hyunkyung Jung, Gwang Lee, Tae Hwan Shin, Seung Jin Han, Kwan Woo Lee, Yoonjung Hwang, Yup Kang, Hae Jin Kim, Hyun Kyu Song, Jongsook Kim Kemper, Seokho Park, Soo-Jin Lee, Youngho Son, Sung-E Choi   +27 more
core   +1 more source