Results 21 to 30 of about 10,075 (175)

Soil Microbial Activity and Diversity in Response to Soil Chemical Factors in Agricultural Soils

Journal of Tropical Soils, 2019
The role of microbial communities in maintaining soil health is mostly influenced by chemical condition of soil. Microbial communities vary in response to soil chemical factors.
Lily Ishak, Philip Hugh Brown
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Selective activator of human ClpP triggers cell cycle arrest to inhibit lung squamous cell carcinoma

Nature Communications, 2023
Chemo-activation of mitochondrial ClpP exhibits promising anticancer properties. However, we are currently unaware of any studies using selective and potent ClpP activators in lung squamous cell carcinoma.
Lin-Lin Zhou, Tao Zhang, Yun Xue, Chuan Yue, Yihui Pan, Pengyu Wang, Teng Yang, Meixia Li, Hu Zhou, Kan Ding, Jianhua Gan, Hongbin Ji, Cai-Guang Yang   +12 more
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Ureadepsipeptides as ClpP Activators

ACS Infectious Diseases, 2019
Acyldepsipeptides are a unique class of antibiotics that act via allosterically dysregulated activation of the bacterial caseinolytic protease (ClpP). The ability of ClpP activators to kill nongrowing bacteria represents a new opportunity to combat deep-seated biofilm infections.
Elizabeth C. Griffith, Ying Zhao, Aman P. Singh, Brian P. Conlon, Rajendra Tangallapally, William R. Shadrick, Jiuyu Liu, Miranda J. Wallace, Lei Yang, John M. Elmore, Yong Li, Zhong Zheng, Darcie J. Miller, Martin N. Cheramie, Robin B. Lee, Michael D. LaFleur, Kim Lewis, Richard E. Lee   +17 more
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Catalytic Properties of Caseinolytic Protease Subunit of Plasmodium knowlesi and Its Inhibition by a Member of δ-Lactone, Hyptolide

Molecules, 2022
The caseinolytic protease (Clp) system plays an essential role in the protein homeostasis of the malaria parasite, particularly at the stage of apicoplast development. The inhibition of this protein is known to have a lethal effect on the parasite and is
Cahyo Budiman, Raimalynah Abd Razak, Angelesa Runin Anak Unggit, Rafida Razali, Meiny Suzery, Ruzaidi Azli Mohd Mokhtar, Ping-Chin Lee, Didik Huswo Utomo   +7 more
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ClpP/ClpX deficiency impairs mitochondrial functions and mTORC1 signaling during spermatogenesis

Communications Biology, 2023
Caseinolytic protease proteolytic subunit (ClpP) and caseinolytic protease X (ClpX) are mitochondrial matrix peptidases that activate mitochondrial unfolded protein response to maintain protein homeostasis in the mitochondria.
Chenxi Guo, Yuan Xiao, Jingkai Gu, Peikun Zhao, Zhe Hu, Jiahuan Zheng, Renwu Hua, Zhuo Hai, Jiaping Su, Jian V. Zhang, William S. B. Yeung, Tianren Wang   +11 more
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Complementation studies with human ClpP in Bacillus subtilis

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2020
ATP-dependent intracellular proteolysis is essential for all living organisms. ClpP, the proteolytic subunit of the ATP-dependent Clp proteases, shares 56% protein identity between B. subtilis and man. The aim of this study was to verify, whether human ClpP (HClpP) is able to substitute the bacterial pendant, BClpP, irrespectively of the huge ...
Denise, Dittmar, Alexander, Reder, Rabea, Schlüter, Katharina, Riedel, Michael, Hecker, Ulf, Gerth   +5 more
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A sensitive soil biological indicator to changes in land-use in regions with Mediterranean climate

Scientific Reports, 2022
The demand for reliable indicators to quantify soil health has increased recently. We propose and test the use of soil microbial functional diversity as an indicator of multifunctional performance in agriculturally important areas. Agricultural fields in
Yosef Steinberger, Alfred Stein, Michael Dorman, Tal Svoray, Tirza Doniger, Oshri Rinot, Eshel Gil   +6 more
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CLPP inhibition triggers apoptosis in human ovarian granulosa cells via COX5A abnormality–Mediated mitochondrial dysfunction

Frontiers in Genetics, 2023
Premature ovarian insufficiency (POI) is characterized by early loss of ovarian function before the age of 40 years. It is confirmed to have a strong and indispensable genetic component.
Xiong Yuan, Xiong Yuan, Wenjie Ma, Wenjie Ma, Shuping Chen, Shuping Chen, Huiyuan Wang, Huiyuan Wang, Chenyi Zhong, Chenyi Zhong, Li Gao, Li Gao, Yugui Cui, Yugui Cui, Danhua Pu, Danhua Pu, Rongrong Tan, Rongrong Tan, Jie Wu, Jie Wu   +19 more
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Dysregulating ClpP: From Antibiotics to Anticancer? [PDF]

Cell Chemical Biology, 2018
In this issue of Cell Chemical Biology, Wong et al. (2018) identify several dysregulators of a key mitochondrial protease: casein lytic protease P (ClpP). These dysregulators were found to trigger programmed cell death and may offer fresh avenues for the development of novel cancer therapeutics.
David A, Dougan, Ingo, Hantke, Kürşad, Turgay   +2 more
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Quercetin Reduces the Virulence of S. aureus by Targeting ClpP to Protect Mice from MRSA-Induced Lethal Pneumonia

Microbiology Spectrum, 2022
The dramatic increase of methicillin-resistant Staphylococcus aureus (MRSA) poses a great challenge to the treatment of Staphylococcus aureus (S. aureus) infections. Therefore, there is an urgent need to identify novel anti-infective agents to attack new
Shisong Jing, Xiangri Kong, Li Wang, Heming Wang, Jiaxuan Feng, Lin Wei, Ying Meng, Chang Liu, Xiren Chang, Yishen Qu, Jiyu Guan, Haimiao Yang, Chi Zhang, Yicheng Zhao, Wu Song   +14 more
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