Results 11 to 20 of about 13,300 (205)
Mechanism of allosteric activation in human mitochondrial ClpP protease
Proceedings of the National Academy of Sciences of the United States of AmericaHuman ClpP protease contributes to mitochondrial protein quality control by degrading misfolded proteins. ClpP is overexpressed in cancers such as acute myeloid leukemia (AML), where its inhibition leads to the accumulation of damaged respiratory chain ...
Siavash Vahidi +2 more
exaly +4 more sources
Effects of ClpP protease on biofilm formation of Enterococcus faecalis [PDF]
Journal of Applied Oral Science, 2021 Enterococcus faecalis (E. faecalis), one of the main pathogens responsible for refractory periapical periodontitis and nosocomial infections, exhibits markedly higher pathogenicity in biofilms. Objectives Studies have shown that caseinolytic protease P
Ying FENG +4 more
doaj +6 more sources
Bacterial ClpP Protease Is a Potential Target for Methyl Gallate [PDF]
Frontiers in Microbiology, 2021 Methyl gallate (MG) is an effective microbicide with great potential application in the integrated management of plant diseases and an important potential drug for clinical application. However, its target remains unknown.
Dehong Zheng +4 more
doaj +3 more sources
Structure of the central Staphylococcus aureus AAA+ protease MecA/ClpC/ClpP [PDF]
Communications BiologyBacterial AAA+ proteases are composed of a AAA+ partner (e.g., ClpC) and an associated peptidase (e.g., ClpP). They represent ATP-fuelled and self-compartmentalized proteolytic machines that are crucial for stress resistance and virulence.
Stavros Azinas +6 more
doaj +2 more sources
Characterization of TR‐107, a novel chemical activator of the human mitochondrial protease ClpP
Pharmacology Research & Perspectives, 2022 We recently described the identification of a new class of small‐molecule activators of the mitochondrial protease ClpP. These compounds synthesized by Madera Therapeutics showed increased potency of cancer growth inhibition over the related compound ...
Emily M. J. Fennell +16 more
doaj +2 more sources
Mitochondrial ClpP-Mediated Proteolysis Induces Selective Cancer Cell Lethality
Cancer Cell, 2019 Summary The mitochondrial caseinolytic protease P (ClpP) plays a central role in mitochondrial protein quality control by degrading misfolded proteins.
Samir H Barghout +2 more
exaly +2 more sources
Cellular functions of the ClpP protease impacting bacterial virulence
Frontiers in Molecular Biosciences, 2022 Proteostasis mechanisms significantly contribute to the sculpting of the proteomes of all living organisms. ClpXP is a central AAA+ chaperone-protease complex present in both prokaryotes and eukaryotes that facilitates the unfolding and subsequent ...
Mazen E. Aljghami +4 more
semanticscholar +4 more sources
LONP1 and ClpP cooperatively regulate mitochondrial proteostasis for cancer cell survival
Oncogenesis, 2021 Mitochondrial proteases are key components in mitochondrial stress responses that maintain proteostasis and mitochondrial integrity in harsh environmental conditions, which leads to the acquisition of aggressive phenotypes, including chemoresistance and ...
Yu Geon Lee +8 more
doaj +2 more sources
Structural insights into the evolutionary simplification of human ClpP activators.
Structure, 2023 In this issue of Structure, Mabanglo et al. characterize five ClpP agonists termed TRs. The co-crystal structures reveal more robust shape and charge complementarities than the anti-cancer agent ONC201.
Lin-Lin Zhou, Cai-Guang Yang
semanticscholar +3 more sources
Cell Reports MedicineSummary: Inflammatory bowel disease (IBD) is an autoimmune disorder, and despite the availability of multiple Food and Drug Administration (FDA)-approved therapies, current clinical needs remain unmet. In this study, we find that caseinolytic protease P (
Jiangnan Zhang +13 more
doaj +2 more sources