Results 11 to 20 of about 10,075 (175)
The cryo-EM structure of the chloroplast ClpP complex [PDF]
Nature Plants, 2021 Protein homoeostasis in plastids is strategically regulated by the protein quality control system involving multiple chaperones and proteases, among them the Clp protease. Here, we determined the structure of the chloroplast ClpP complex from Chlamydomonas reinhardtii by cryo-electron microscopy. ClpP contains two heptameric catalytic rings without any
Wang, Ning +10 more
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Generation of Lasso Peptide-Based ClpP Binders [PDF]
International Journal of Molecular Sciences, 2021 The Clp protease system fulfills a plethora of important functions in bacteria. It consists of a tetradecameric ClpP barrel holding the proteolytic centers and two hexameric Clp-ATPase rings, which recognize, unfold, and then feed substrate proteins into the ClpP barrel for proteolytic degradation.
Imran T. Malik +2 more
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ClpP regulates breast cancer cell proliferation, invasion and apoptosis by modulating the Src/PI3K/Akt signaling pathway [PDF]
PeerJ, 2020 Background Caseinolytic protease P (ClpP), which is located on the inner mitochondrial membrane, degrades mitochondrial proteins damaged by oxidative stress. The role of ClpP varies among tumor types.
Juan Luo +4 more
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Modeling and Simulation of Dissemination of Cultivated Land Protection Policies in China
Land, 2021 Cultivated land protection is the top priority of the national economy in China and the livelihood of people. Cultivated land protection policies (CLPP) play an important role in the protection of cultivated land. However, the process of dissemination of
Xinhai Lu, Yanwei Zhang, Handong Tang
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Human CLPP reverts the longevity phenotype of a fungal ClpP deletion strain [PDF]
Nature Communications, 2013 Mitochondrial maintenance crucially depends on the quality control of proteins by various chaperones, proteases and repair enzymes. While most of the involved components have been studied in some detail, little is known on the biological role of the CLPXP protease complex located in the mitochondrial matrix.
Fischer, Fabian +3 more
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Virulence, 2022 The resistance of Staphylococcus aureus (S. aureus) to various antibiotics has increased dramatically due to the misuse of antibiotics, and thus the development of new anti-infective drugs with new targets is urgently needed to combat resistance ...
Shisong Jing +12 more
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Mitochondrial Stress Response Gene Clpp Is Not Required for Granulosa Cell Function
Antioxidants, 2020 Mitochondrial unfolded protein response (UPRmt) is a highly conserved mechanism, which is activated upon cellular or metabolic stress and aims to help cells maintain homeostasis.
Ecem Esencan +3 more
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The ClpP protease is required for the stress tolerance and biofilm formation in Actinobacillus pleuropneumoniae. [PDF]
PLoS ONE, 2013 In the respiratory tract and lung tissue, a balanced physiological response is essential for Actinobacillus pleuropneumoniae to survive various types of challenges.
Fang Xie +5 more
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Turned on for degradation: ATPase-independent degradation by ClpP [PDF]
Journal of Structural Biology, 2009 Clp is a barrel-shaped hetero-oligomeric ATP-dependent protease comprising a hexameric ATPase (ClpX or ClpA) that unfolds protein substrates and translocates them into the central chamber of the tetradecameric proteolytic component (ClpP) where they are degraded processively to short peptides. Chamber access is controlled by the N-terminal 20 residues (
Maria C, Bewley +3 more
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Ecological Indicators, 2021 The evaluation of the effects of cultivated land protection policies (CLPP) is an important issue in China’s food security and land policy regulation. This article first analyzes the historical evolution of CLPP in China and divides it into five stages ...
Xinhai Lu, Yanwei Zhang, Yucheng Zou
doaj +1 more source