NLK facilitates Caspase-8 activation to drive macrophage PANoptosis in sepsis. [PDF]
Clin Transl MedMounting evidence indicates that macrophage PANoptosis—an integrated inflammatory cell‐death program comprising pyroptosis, apoptosis, and necroptosis—plays a pivotal role in sepsis pathogenesis. However, its upstream regulation remains poorly understood.
Xia Y +17 more
europepmc +4 more sources
Expressão gênica de caspases 3 e 8 em timo e baço de ratas recém-desmamadas e imunossuprimidas por glicocorticóide [PDF]
Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 2005 Determinou-se a expressão gênica das caspases 3 e 8 mediante transcrição reversa de mRNA total e reação em cadeia da polimerase (RT-PCR) para avaliar a apoptose em timo e baço de ratas imunossuprimidas por glicocorticóides.
J.J. Batista +3 more
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Downregulation of Caspase 8 in a group of Iranian breast cancer patients – A pilot study
Journal of the Egyptian National Cancer Institute, 2017 Purpose: It is now well known that evading apoptosis, as a cancer hallmark, can lead to tumour initiation, progression and metastasis. As a result of genome wide association studies, an initiator protease in this pathway, caspase 8 (CASP8), has been ...
Masoumeh Aghababazadeh +5 more
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Changes in Expression Profiles of Caspase-8 and Mixed Lineage Kinase Domain-Like Protein/Receptor-Interacting Protein Kinase 3 Mediated by Inflammation in Cerebral Arteriovenous Malformations Associated With Clinical Condition on Admission. [PDF]
J Am Heart AssocBackground Cerebral arteriovenous malformations (cAVMs) are complex vascular anomalies carrying a high risk of hemorrhage due to abnormal arteriovenous connections.
Shimada K +9 more
europepmc +2 more sources
Glutathione peroxidase 8 negatively regulates caspase‐4/11 to protect against colitis
EMBO Molecular Medicine, 2019 Human caspase‐4 and its mouse homolog caspase‐11 are receptors for cytoplasmic lipopolysaccharide. Activation of the caspase‐4/11‐dependent NLRP3 inflammasome is required for innate defense and endotoxic shock, but how caspase‐4/11 is modulated remains ...
Jye‐Lin Hsu +9 more
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Neurobiology of Disease, 2021 Retinal ganglion cells (RGCs) expanding from the retina to the brain are primary victims of neurodegeneration in glaucoma, a leading cause of blindness; however, the neighboring astroglia survive the glaucoma-related stress and promote neuroinflammation.
Xiangjun Yang, Qun Zeng, Gülgün Tezel
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Biomimetic dual-crosslinked GelMA-SilMA hydrogel microneedle for delivering DSPE-PEG2K-TAT-modified quercetin liposomes to treat rheumatoid arthritis via the caspase-8/caspase-3/GSDME pathway. [PDF]
J NanobiotechnologyRheumatoid arthritis (RA) is a chronic inflammatory disease characterized by synovitis, whose pathogenesis remains unclear. Fibroblast-like synoviocytes (FLS) are central to the pathogenesis and progression of RA. This study aims to investigate the novel
Zheng Q, Lin R, Chen R, Xu W.
europepmc +2 more sources
A Potent Inhibitor of Caspase‑8 Based on the IL-18 Tetrapeptide Sequence Reveals Shared Specificities between Inflammatory and Apoptotic Initiator Caspases. [PDF]
ACS Bio Med Chem AuBourne CM +15 more
europepmc +2 more sources
Obesity Science & Practice, 2023 Mechanisms underlying the negative effects of obesity on the brain are still unknown. Obesity is associated with oxidative stress in the brain and neuroinflammation that promotes neurodegenerative diseases.
Erick Gómez‐Apo +4 more
doaj +1 more source
Cancer Reports, 2022 Background Pyroptosis plays a dual role in the development of cancer and malignancy; as such, it may potentially be a new target for cancer treatment. However, the inflammatory response to pyroptosis may have adverse effects on the body.
Yuan‐Li Huang +4 more
doaj +1 more source