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FLICE Is Predominantly Expressed as Two Functionally Active Isoforms, Caspase-8/a and Caspase-8/b [PDF]
Journal of Biological Chemistry, 1997 Induction of apoptosis by the cell surface receptor CD95 (APO-1/Fas) has been shown to involve activation of a family of cysteine proteases (caspases). Recently, a new member of this family has been identified, designated FLICE (caspase-8/MACH/Mch5). FLICE is part of the CD95 death-inducing signaling complex and is therefore the most upstream caspase ...
Scaffidi, C. +3 more
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TNF-α contributes to sarcopenia through caspase-8/caspase-3/GSDME-mediated pyroptosis
Cell Death Discovery, 2023 Sarcopenia has become a leading cause of disability and mortality in the elderly. It has been reported that programmed cell death (PCD) is associated with the development of sarcopenia that is characterized by reduction of muscle fiber size and number ...
Jingying Wu +9 more
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Frontiers in Microbiology, 2022 Programmed cell death (PCD) is an important mechanism of innate immunity against bacterial pathogens. The innate immune PCD pathway involves the molecules caspase-7 and caspase-8, among others.
Raiany A. Santos +5 more
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Journal of Translational Autoimmunity, 2020 Glucocorticoids promote thymocyte apoptosis and modulate transcription of numerous regulators of thymic apoptosis. Among these, glucocorticoid-induced leucine zipper (GILZ) is strongly upregulated in the thymus.
Isabella Muscari +8 more
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Caspase‐8: not so silently deadly
Clinical & Translational Immunology, 2017 Apoptosis is a caspase‐dependent programmed form of cell death, which is commonly believed to be an immunologically silent process, required for mammalian development and maintenance of cellular homoeostasis. In contrast, lytic forms of cell death, such as RIPK3‐ and MLKL‐driven necroptosis, and caspase‐1/11‐dependent pyroptosis, are postulated to be ...
Feltham, R, Vince, JE, Lawlor, KE
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Tyrosine Phosphorylation of Caspase-8 Abrogates Its Apoptotic Activity and Promotes Activation of c-Src. [PDF]
PLoS ONE, 2016 Src family tyrosine kinases (SFKs) phosphorylate caspase-8A at tyrosine (Y) 397 resulting in suppression of apoptosis. In addition, the phosphorylation of caspase-8A at other sites including Y465 has been implicated in the regulation of caspase-8 ...
Jennifer Ly Tsang +8 more
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Cell Death and Disease, 2021 Caspase-8 is a unique member of caspases with a dual role in cell death and survival. Caspase-8 expression is often lost in some tumors, but increased in others, indicating a potential pro-survival function in cancer.
Jia Xia +10 more
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Functions of caspase 8: The identified and the mysterious [PDF]
Seminars in Immunology, 2014 Initially discovered as an initiator protease in apoptosis mediated by death receptors, caspase-8 is now known to have an apparently confounding opposing effect in securing cell survival. It is required to allow mouse embryo survival, and the survival of hematopoietic cells during their development and activation.
Salvesen, Guy S, Walsh, Craig M
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Irisin Protects Against Hind Limb Ischemia Reperfusion Injury
Drug Design, Development and Therapy, 2021 Ayşegül Küçük,1,* Yücel Polat,2 Aydan Kılıçarslan,3 Nuran Süngü,3 Hakan Kartal,4 Ali Doğan Dursun,5,* Mustafa Arslan6 1Kutahya Health Sciences University, Medical Faculty, Department of Physiology, Kutahya ...
Küçük A +6 more
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Neurobiology of Disease, 2003 Abnormal Tau protein is known to be closely associated with several neurodegenerative diseases. Previously, we showed that Tau was cleaved by caspase-3 to generate the cleavage product lacking the C-terminus (ΔTau-1) during neuronal cell death.
Chul-Woong Chung +6 more
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