Results 1 to 10 of about 7,578,422 (291)

NLK facilitates Caspase‐8 activation to drive macrophage PANoptosis in sepsis [PDF]

Clinical and Translational Medicine
Mounting evidence indicates that macrophage PANoptosis—an integrated inflammatory cell‐death program comprising pyroptosis, apoptosis, and necroptosis—plays a pivotal role in sepsis pathogenesis. However, its upstream regulation remains poorly understood.
Yun Xia, Ren‐qi Yao, Hui‐fan Liu, Guo‐qing Jing, Delida Aidebaike, Jing Zuo, Shi‐qi Wan, Die Wu, Peng‐yue Zhao, Hai‐long Gong, Xing Wang, Hui‐min Zhou, Ning Dong, Yao Wu, Shi Liu, Xiao‐jing Wu, Yong‐ming Yao, Xue‐min Song   +17 more
doaj   +2 more sources

Adipocyte caspase-8 but not RIPK3 promotes adiposity [PDF]

Cell Death Discovery
Adipocyte death is a key event in the development of white adipose tissue (WAT) inflammation, a major driver of obesity-associated metabolic dysfunction.
Carmen K. Chan, Rukhsana Aslam, Fan Yang, Arshdeep Panesar, Anne Hakem, Razqallah Hakem, Herbert Y. Gaisano, Daniel A. Winer, Cynthia T. Luk   +8 more
doaj   +2 more sources

Loss of DNA methyltransferase 3a enhances Caspase-8 transcription and promotes cardiomyocyte pyroptosis during myocardial infarction [PDF]

Nature Communications
Aspartate-specific cysteine protease (Caspase)-8 plays a critical role in initiating pyroptosis by mediating cleavage and activation of gasdermin-D (Gsdmd) during Yersinia infection.
Ning Wang, Liling Gong, Xingmiao Zhao, Wenshuang Zhao, Ning Xu, Ximing Chen, Qingwei Zhang, Ming Li, Yijing Yao, Hang Yu, Qingsui Li, Zhen Zhang, Liwei Zhu, Long Qin, Xu Su, Zhen Zhang, Wei Li, Wanyu Zhang, Yadong Xue, Xianzhi Lang, Pengyu Li, Sijia Li, Siyu Chang, Jiamin Li, Benzhi Cai   +24 more
doaj   +2 more sources

Activation of the NLRP1B inflammasome by caspase-8. [PDF]

Commun Biol
Cleavage of the innate immune receptor NLRP1B by various microbial proteases causes the proteasomal degradation of its N-terminal fragment and the subsequent release of a C-terminal fragment that forms an inflammasome. We reported previously that metabolic stress caused by intracellular bacteria triggers NLRP1B activation, but the mechanism by which ...
Meade JJ, Stuart S, Neiman-Zenevich J, Krustev C, Girardin SE, Mogridge J.   +5 more
europepmc   +4 more sources

The CULt of Caspase-8 Ubiquitination [PDF]

Cell, 2009
Caspase-8 is activated at the plasma membrane by the death-inducing signaling complex (DISC). Jin et al. (2009) show that polyubiquitination of caspase-8, rather than targeting it for proteasomal degradation, is critical for sustaining caspase-8 activity after dissociation from the DISC.
Békés, Miklós, Salvesen, Guy S.
openaire   +3 more sources

Evaluation of the Potential Diagnostic Utility of the Determination of Selected Caspases—Markers Involved in the Regulation of Apoptosis—In Patients with Ovarian Cancer

Diagnostics, 2021
Ovarian cancer remains a major diagnostic and therapeutic problem in modern gynecological oncology. For this reason, research which focuses on the search for new diagnostic markers and the assessment of their possible usefulness in clinical practice is ...
Aleksandra Mielczarek-Palacz, Sylwia Jasińska, Anna Strzelec   +2 more
doaj   +1 more source

GENETIC POLYMORHISM OF CASPASE 8 AND 9 IN IRAQ

The Iraqi Journal of Agricultural science, 2022
This study examined the potential association between polymorphisms of Caspase 9 −293del (rs4645982) and Caspase8−652 6N ins / del (rs3834129) and the danger of acute and chronic myeloid leukaemia in Iraqi population.
Duaa Abdullah , Reema M. Aloubaidy
doaj   +1 more source

Immunohistochemical analysis of caspase expression in the brains of individuals with obesity or overweight

Obesity Science & Practice, 2023
Mechanisms underlying the negative effects of obesity on the brain are still unknown. Obesity is associated with oxidative stress in the brain and neuroinflammation that promotes neurodegenerative diseases.
Erick Gómez‐Apo, Juan Silva‐Pereyra, Virgilia Soto‐Abraham, Alejandra Mondragón‐Maya, Javier Sanchez‐Lopez   +4 more
doaj   +1 more source

Serum Interleukin-13 and Caspase 8 are Elevated in Prurigo Nodularis

Acta Dermato-Venereologica, 2023
is missing (Short communication)
Teresa Ju, Angelina Labib, Leigh Nattkemper, Sarah Engle, Autum Auxier, Nathan Hahn, Sean Sissons, Jonathan T. Sims, Zhe Sun, Angela J. Okragly, Gil Yosipovitch   +10 more
doaj   +1 more source

Caspase‐8 in Apoptosis: The Beginning of “The End”? [PDF]

IUBMB Life, 2000
AbstractCaspase‐8 is a member of the cysteine proteases, which are implicated in apoptosis and cytokine processing. Like all caspases, caspase‐8 is synthesized as an inactive single polypeptide chain zymogen procaspase and is activated by proteolytic cleavage, through either autoactivation after recruitment into a multimeric complex or trans‐cleavage ...
M, Kruidering, G I, Evan
openaire   +2 more sources