Results 1 to 10 of about 4,575,594 (299)
Caspase-8 and Caspase-9 Functioned Differently at Different Stages of the Cyclic Stretch-Induced Apoptosis in Human Periodontal Ligament Cells. [PDF]
PLoS ONE, 2016 Human periodontal ligament (PDL) cells underwent apoptosis after mechanical stretch loading. However, the exact signalling pathway remains unknown.
Yaqin Wu +4 more
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Journal of Pharmacological Sciences, 2011 The present study investigated the function of caspase-4 in endoplasmic reticulum (ER) stress–induced apoptosis in human neuronal cell line SH-SY5Y.
Akiko Yamamuro +6 more
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Oncogene-dependent apoptosis is mediated by caspase-9 [PDF]
Proceedings of the National Academy of Sciences, 1998 Understanding how oncogenic transformation sensitizes cells to apoptosis may provide a strategy to kill tumor cells selectively. We previously developed a cell-free system that recapitulates oncogene dependent apoptosis as reflected by activation of caspases, the core of the apoptotic machinery.
H O, Fearnhead +6 more
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Effect of chlorpyrifos on the level of hippocampal caspase 9 in male rats: Short Commuincation
مجله دانشگاه علوم پزشکی بیرجند, 2023 Chlorpyrifos (CPF) is an organophosphate pesticide that can damage the nervous system of insects by causing neurotoxicity. Although the molecular mechanisms related to it are not fully understood, some studies have suggested that apoptotic processes are ...
Sina Nikbin +3 more
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Expression of caspase 9 and p53 in uterine leiomyosarcomas
Polish Gynaecology, 2014 Uterine sarcomas are heterogeneous malignancies, both clinically and histologically. The process of oncogenesis depends on gene mutations and uncontrolled mitotic cell division that is promoted by blocking pathways of apoptosis. Caspase 9 and p53 protein play an important role in the process of cell apoptosis.The aim of the study was to assess the ...
Krzysztof, Kułak +5 more
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Prediction of the tertiary structure of a caspase‐9/inhibitor complex [PDF]
FEBS Letters, 2000 Apoptosis, or programmed cell death, plays a central role in the development and homeostasis of an organism. The breakdown of cellular proteins in apoptosis is mediated by caspases, which comprise a highly conserved family of cysteine proteases with specificity for aspartic acid residues at the P1 positions of their substrates.
Chou, Kuo-Chen +2 more
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Vaccinia Virus Protein F1L Is a Caspase-9 Inhibitor [PDF]
Journal of Biological Chemistry, 2010 Apoptosis plays important roles in host defense, including the elimination of virus-infected cells. The executioners of apoptosis are caspase family proteases. We report that vaccinia virus-encoded F1L protein, previously recognized as anti-apoptotic viral Bcl-2 family protein, is a caspase-9 inhibitor. F1L binds to and specifically inhibits caspase-9,
Dayong, Zhai +8 more
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Veterinární Medicína, 2013 The aim of this study was to examine the expression of caspase-3, caspase-7, caspase-9 and cytokeratin AE-1/AE-3 using the avidin-biotin complex (ABC) immunoperoxidase technique in 20 goats with enzootic nasal adenocarcinoma (ENA).
A. Aydogan, M. Haligur, O. Ozmen
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A non-apoptotic role for caspase-9 in muscle differentiation [PDF]
Journal of Cell Science, 2008 Caspases, a family of cysteine proteases most often investigated for their roles in apoptosis, have also been demonstrated to have functions that are vital for the efficient execution of cell differentiation. One such role that has been described is the requirement of caspase-3 for the differentiation of skeletal myoblasts into myotubes but, as yet ...
Murray, Thomas VA +7 more
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Caspase-9 Can Be Activated without Proteolytic Processing [PDF]
Journal of Biological Chemistry, 1999 The recombinant form of the proapoptotic caspase-9 purified following expression in Escherichia coli is processed at Asp315, but largely inactive; however, when added to cytosolic extracts of human 293 cells it is activated 2000-fold in the presence of cytochrome c and dATP.
H R, Stennicke +5 more
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