Effect of Gynura procumbens (Lour.) Merr. on the histopathology of the diabetic pancreas via caspase family expression [PDF]
Journal of Pharmacy & Pharmacognosy ResearchContext: Diabetes is a prominent cause of mortality globally, particularly in Indonesia. Elevated glucose levels stimulate insulin secretion from pancreatic β cells. A variety of drugs, including oral treatments and synthetic insulin, have been developed
Putri Cahaya Situmorang +4 more
doaj +1 more source
Uterine Endoplasmic Reticulum Stress and Its Unfolded Protein Response May Regulate Caspase 3 Activation in the Pregnant Mouse Uterus [PDF]
, 2013 We have previously proposed that uterine caspase-3 may modulate uterine contractility in a gestationally regulated fashion. The objective of this study was to determine the mechanism by which uterine caspase-3 is activated and consequently controlled in ...
Subedi, Kalpana +12 more
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The Docking Interaction of Caspase-9 with ERK2 Provides a Mechanism for the Selective Inhibitory Phosphorylation of Caspase-9 at Threonine 125 [PDF]
Journal of Biological Chemistry, 2008 Caspase-9 plays a critical role in the initiation of apoptosis by the mitochondrial pathway. Activation of caspase-9 is inhibited by phosphorylation at Thr(125) by ERK1/2 MAPKs in response to growth factors. Here, we show that phosphorylation of this site is specific for these classical MAPKs and is not strongly induced when JNK and p38alpha/beta MAPKs
Martin, Morag C. +3 more
openaire +4 more sources
Mechanism of zinc‐mediated inhibition of caspase‐9 [PDF]
Protein Science, 2012 AbstractZinc‐mediated inhibition is implicated in global caspase regulation, with relief of zinc‐mediated inhibition central to both small‐molecule and natively induced caspase activation. As an initiator, caspase‐9 regulates the upstream stages of the apoptotic caspase cascade, making it a critical control point.
Kristen L, Huber, Jeanne A, Hardy
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, 2022 Western blot of pro- and cleaved caspase-3 [ratio to ß-actin]. Shown are representative blots separated by location of lung tissue sampling (contusion site, ipsilateral control, and contralateral control). Lung tissue samples were homogenized, separated,
Martin Sassen (14232410) +7 more
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Cells, 2012 Persistent cell shrinkage is a major hallmark of apoptotic cell death. The early-phase shrinkage, which starts within 30−120 min after apoptotic stimulation and is called apoptotic volume decrease (AVD), is known to be accomplished by activation of K ...
Takeshi Tsubata +2 more
doaj +1 more source
Anti-GBM glomerulonephritis involves IL-1 but is independent of NLRP3/ASC inflammasome-mediated activation of caspase-1 [PDF]
, 2011 IL-1b and IL-18 are proinflammatory cytokines that contribute to renal immune complex disease, but whether IL-1b and IL-18 are mediators of intrinsic glomerular inflammation is unknown.
Volker Vielhauer +47 more
core +1 more source
Caspase-3/-6/-8 are required for Gsdme-dependent pyroptosis.
, 2022 a Images and cell viability of WT, Nlrp3-/-, Caspase-1-/- and Gsdmd-/- BMDMs left untreated or stimulated with ATP and silica. Arrowheads indicate pyroptotic cells. The scale bar represents 100 μm.
Yujie Zou (408340) +12 more
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Caspase-9 deficiency amplifies macrophage infiltration into staphylococcal abscesses.
, 2023 (A-P) Immunofluorescence microscopy-based detection of F4/80-positive macrophages in renal or liver tissues isolated 5 days after intravenous injection of 107 CFU of wild-type (WT) S.
Sebastian Koch (2234521) +4 more
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Caspase-9 plays only a minor role in TRAIL-induced apoptosis in NCI-H460 cells.
, 2018 (A) Cells were preincubated with caspase-9 inhibitor (z-LEHD-fmk, 50 μM) for 1 h, followed by stimulation with serial dilutions of Db-scTRAIL for 24 h. Viable cells were stained with crystal violet and absorbance was measured at 550 nm.
Lubna Danish (5434982) +4 more
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