Structure and Activation Mechanism of the Drosophila Initiator Caspase Dronc [PDF]
, 2006 Activation of an initiator caspase is essential to the execution of apoptosis. The molecular mechanisms by which initiator caspases are activated remain poorly understood.
Demeler, Borries +5 more
core +1 more source
Thy-1 interaction with Fas in lipid rafts regulates fibroblast apoptosis and lung injury resolution. [PDF]
, 2017 Thy-1-negative lung fibroblasts are resistant to apoptosis. The mechanisms governing this process and its relevance to fibrotic remodeling remain poorly understood. By using either sorted or transfected lung fibroblasts, we found that Thy-1 expression is
Bradley, John E +11 more
core +1 more source
Apoptosome activation, an important molecular instigator in 6-mercaptopurine induced Leydig cell death. [PDF]
, 2015 Leydig cells are crucial to the production of testosterone in males. It is unknown if the cancer chemotherapeutic drug, 6-mercaptopurine (6 MP), produces Leydig cell failure among adult survivors of childhood acute lymphoblastic leukemia. Moreover, it is
Bao, Ju +11 more
core +1 more source
Small inhibitor of Bcl-2, HA14-1, selectively enhanced the apoptotic effect of cisplatin by modulating Bcl-2 family members in MDA-MB-231 breast cancer cells [PDF]
, 2010 Inhibition or downregulation of Bcl-2 represents a new therapeutic approach to by-pass chemoresistance in cancer cells. Therefore, we explored the potential of this approach in breast cancer cells.
A Letai +34 more
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Caspase-9: structure, mechanisms and clinical application
Oncotarget, 2017 As the most intensively studied initiator caspase, caspase-9 is a key player in the intrinsic or mitochondrial pathway which is involved in various stimuli, including chemotherapies, stress agents and radiation. Caspase-9 is activated on the apoptosome complex to remain catalytic status and is thought of involving homo-dimerization monomeric zymogens ...
Li, Ping +7 more
openaire +3 more sources
ROS‐dependent caspase‐9 activation in hypoxic cell death [PDF]
FEBS Letters, 2003 Mitochondria are known to play a fundamental role in apoptosis by releasing apoptogenic molecules such as cytochrome c into the cytoplasm, thereby sequentially activating initiator caspase‐9. However, the mechanisms of cytochrome c release or caspase‐9 activation in response to hypoxia are unclear. In this report, we show that caspase‐9 is activated by
Kim, Jee-Youn, Park, Jae-Hoon
openaire +2 more sources
Monoamine oxidase A expression is vital for embryonic brain development by modulating developmental apoptosis [PDF]
, 2011 Monoamine oxidases (MAO-A, MAO-B) metabolize biogenic amines and have been implicated in neuronal apoptosis. Although apoptosis is an important process in embryo development, the role of MAO isoenzymes has not been investigated in detail.
Alwan +45 more
core +1 more source
Caspase-9 cleavage, do you need it? [PDF]
Biochemical Journal, 2007 Caspase-9, which is activated by association with the Apaf-1 (apoptotic protease-activating factor-1) apoptosome complex, cleaves and activates the downstream effector caspases-3 and -7, thereby executing the caspase-cascade and cell-death programme. Although caspase-9 does not need to be cleaved to be active, apoptotic cell death is always accompanied
Twiddy, Davina, Cain, Kelvin
openaire +2 more sources
Effect of chlorpyrifos on the level of hippocampal caspase 9 in male rats: Short Commuincation
مجله دانشگاه علوم پزشکی بیرجند, 2023 Chlorpyrifos (CPF) is an organophosphate pesticide that can damage the nervous system of insects by causing neurotoxicity. Although the molecular mechanisms related to it are not fully understood, some studies have suggested that apoptotic processes are ...
Sina Nikbin +3 more
doaj
Journal of Pharmacological Sciences, 2011 The present study investigated the function of caspase-4 in endoplasmic reticulum (ER) stress–induced apoptosis in human neuronal cell line SH-SY5Y.
Akiko Yamamuro +6 more
doaj +1 more source