Results 51 to 60 of about 4,575,594 (299)

The Dimeric Caspase-9 Closely Resembles the WT Caspase-9

, 2013
(A) Overall structure of the dimeric caspase-9 (C287S). The structural core is shown in blue; the solvent-exposed active site loops are shown in magenta. The β6 and β6′ strands are highlighted in red. Note the asymmetry of the dimer.
Eric N Shiozaki (68540), Robert Fairman (68543), Srinivasa M Srinivasula (68541), Yang Chao (68539), Daniel J Rigotti (68542), Yigong Shi (68544)   +5 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Caspase-Dependent and Caspase-Independent Pathways Are Involved in Cadmium-Induced Apoptosis in Primary Rat Proximal Tubular Cell Culture.

, 2016
We designed this study to investigate whether cadmium induces caspase-independent apoptosis and to investigate the relationship between the caspase-dependent and caspase-independent apoptotic pathways.
Xuezhong Liu, Jiaqiao Zhu, Mengfei Long, Hui Zou, Yan Yuan (20767), Yan Yuan, Tongwang Luo (3353570), Jiaqiao Zhu (753911), Gang Liu (81776), Jianhong Gu (753909), Gang Liu, Yi Wang (32470), Zongping Liu, Ruilong Song (827410), Yi Wang, Xuezhong Liu (753908), Zongping Liu (827411), Jianchun Bian (753910), Jianhong Gu, Ruilong Song, Mengfei Long (3353567), Tongwang Luo, Jianchun Bian, Hui Zou (666389)   +23 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Caspase-2S relative mRNA expression levels in neurological disease.

, 2022
(A) Caspase-2S mRNA expression levels trend lower in AD but not MCI compared to CN controls. Caspase-2S mRNA do not differ in LBD (B) or HD (C) compared to controls.
Ronald C. Petersen (9562700), Chris Hlynialuk (12511813), Benjamin Smith (216177), Kailee Leinonen-Wright (12511816), Karen Ashe (7055705), Lisa Kemper (13840174)   +5 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

The protein levels of caspase-12, caspase-9, caspase-3.

, 2014
Western blot bands of cleaved caspase-12, cleaved caspase-9 and cleaved caspase-3 were separately normalized to caspase-12, caspase-9 and caspase-3 ...
Hanpeng Huang (549638), Shijiang Zhang (549639), Xilong Zhang (514791), Ning Ding (456674), Wenxiao Ding (549637), Xiaofeng Zhang (172446), Sean Z. Hutchinson (549640)   +6 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Caspase-9: structure, mechanisms and clinical application

Oncotarget, 2017
As the most intensively studied initiator caspase, caspase-9 is a key player in the intrinsic or mitochondrial pathway which is involved in various stimuli, including chemotherapies, stress agents and radiation. Caspase-9 is activated on the apoptosome complex to remain catalytic status and is thought of involving homo-dimerization monomeric zymogens ...
Li, Ping, Zhou, Libin, Zhao, Ting, Liu, Xiongxiong, Zhang, Pengcheng, Liu, Yan, Zheng, Xiaogang, Li, Qiang   +7 more
openaire   +3 more sources