Results 31 to 40 of about 303,695 (260)

Caspase-8 and Caspase-9 Functioned Differently at Different Stages of the Cyclic Stretch-Induced Apoptosis in Human Periodontal Ligament Cells. [PDF]

PLoS ONE, 2016
Human periodontal ligament (PDL) cells underwent apoptosis after mechanical stretch loading. However, the exact signalling pathway remains unknown.
Yaqin Wu, Dan Zhao, Jiabao Zhuang, Fuqiang Zhang, Chun Xu   +4 more
doaj   +1 more source

Effect of chlorpyrifos on the level of hippocampal caspase 9 in male rats: Short Commuincation

مجله دانشگاه علوم پزشکی بیرجند, 2023
Chlorpyrifos (CPF) is an organophosphate pesticide that can damage the nervous system of insects by causing neurotoxicity. Although the molecular mechanisms related to it are not fully understood, some studies have suggested that apoptotic processes are ...
Sina Nikbin, Armin Derakhshideh, Mohammad Ali Azarbayjani, Nasrin Hosseini   +3 more
doaj  

Expression of caspase 9 and p53 in uterine leiomyosarcomas

Polish Gynaecology, 2014
Uterine sarcomas are heterogeneous malignancies, both clinically and histologically. The process of oncogenesis depends on gene mutations and uncontrolled mitotic cell division that is promoted by blocking pathways of apoptosis. Caspase 9 and p53 protein play an important role in the process of cell apoptosis.The aim of the study was to assess the ...
Krzysztof, Kułak, Marcin, Bobiński, Grzegorz, Polak, Barbara Jodłowska, Jedrych, Jan, Kotarski, Wiesława, Bednarek   +5 more
openaire   +2 more sources

Caspase-4 Directly Activates Caspase-9 in Endoplasmic Reticulum Stress–Induced Apoptosis in SH-SY5Y Cells

Journal of Pharmacological Sciences, 2011
The present study investigated the function of caspase-4 in endoplasmic reticulum (ER) stress–induced apoptosis in human neuronal cell line SH-SY5Y.
Akiko Yamamuro, Takashi Kishino, Yu Ohshima, Yasuhiro Yoshioka, Tomoki Kimura, Atsushi Kasai, Sadaaki Maeda   +6 more
doaj   +1 more source

The expression of caspase-3, caspase-7, caspase-9 and cytokeratin AE1/AE3 in goats with enzootic nasal adenocarcinoma: an immunohistochemical study

Veterinární Medicína, 2013
The aim of this study was to examine the expression of caspase-3, caspase-7, caspase-9 and cytokeratin AE-1/AE-3 using the avidin-biotin complex (ABC) immunoperoxidase technique in 20 goats with enzootic nasal adenocarcinoma (ENA).
A. Aydogan, M. Haligur, O. Ozmen
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Prediction of the tertiary structure of a caspase‐9/inhibitor complex [PDF]

FEBS Letters, 2000
Apoptosis, or programmed cell death, plays a central role in the development and homeostasis of an organism. The breakdown of cellular proteins in apoptosis is mediated by caspases, which comprise a highly conserved family of cysteine proteases with specificity for aspartic acid residues at the P1 positions of their substrates.
Chou, Kuo-Chen, Tomasselli, Alfredo G., Heinrikson, Robert L.   +2 more
openaire   +2 more sources

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Caspase-9: structure, mechanisms and clinical application

Oncotarget, 2017
As the most intensively studied initiator caspase, caspase-9 is a key player in the intrinsic or mitochondrial pathway which is involved in various stimuli, including chemotherapies, stress agents and radiation. Caspase-9 is activated on the apoptosome complex to remain catalytic status and is thought of involving homo-dimerization monomeric zymogens ...
Li, Ping, Zhou, Libin, Zhao, Ting, Liu, Xiongxiong, Zhang, Pengcheng, Liu, Yan, Zheng, Xiaogang, Li, Qiang   +7 more
openaire   +3 more sources