Results 21 to 30 of about 303,695 (260)

Mechanism of XIAP-Mediated Inhibition of Caspase-9 [PDF]

Molecular Cell, 2003
The inhibitor of apoptosis (IAP) proteins potently inhibit the catalytic activity of caspases. While profound insight into the inhibition of the effector caspases has been gained in recent years, the mechanism of how the initiator caspase-9 is regulated by IAPs remains enigmatic.
Shiozaki, Eric N, Chai, Jijie, Rigotti, Daniel J, Riedl, Stefan J, Li, Pingwei, Srinivasula, Srinivasa M, Alnemri, Emad S, Fairman, Robert, Shi, Yigong   +8 more
openaire   +3 more sources

Altered of apoptotic markers of both extrinsic and intrinsic pathways induced by hepatitis C virus infection in peripheral blood mononuclear cells

Virology Journal, 2012
Background Chronic hepatitis C (CHC) has emerged as a leading cause of cirrhosis in the U.S. and across the world. To understand the role of apoptotic pathways in hepatitis C virus (HCV) infection, we studied the mRNA and protein expression patterns of ...
Albertoni Guilherme, Arnoni Carine Prisco, Latini Flávia Roche Moreira, Andrade Sheila Siqueira, Araújo Patrícia Regina Barboza, Rodrigues Flaviane Kesia, Rozenchan Patrícia Bortman, Mendes-Correa Maria Cássia, Leite Olavo Henrique Munhoz, Schor Nestor, Girão Manoel João Castelo Batista, Barreto José   +11 more
doaj   +1 more source

Caspase 9 Promoter Polymorphisms (-1263G>A, -905T>G, -712C>T) in Coronary Artery Disease [PDF]

Journal of Clinical and Diagnostic Research, 2020
Introduction: Apoptosis has been involved in a number of pathological conditions including Coronary Artery Disease (CAD). Caspases are important regulators and executioners in both extrinsic and intrinsic apoptotic pathways.
KISHORE KUMAR GUNDAPANENI, NIVAS SHYAMALA, KAUSHIK PURANAM, RAJESH KUMAR GALIMUDI, KEERTHI KUPSAL, KRISHNA REDDY NALLAMALA, SUREKHA RANI HANUMANTH   +6 more
doaj   +1 more source

The Docking Interaction of Caspase-9 with ERK2 Provides a Mechanism for the Selective Inhibitory Phosphorylation of Caspase-9 at Threonine 125 [PDF]

Journal of Biological Chemistry, 2008
Caspase-9 plays a critical role in the initiation of apoptosis by the mitochondrial pathway. Activation of caspase-9 is inhibited by phosphorylation at Thr(125) by ERK1/2 MAPKs in response to growth factors. Here, we show that phosphorylation of this site is specific for these classical MAPKs and is not strongly induced when JNK and p38alpha/beta MAPKs
Martin, Morag C., Allan, Lindsey A., Mancini, Erika J., Clarke, Paul R.   +3 more
openaire   +5 more sources

Effect of Gynura procumbens (Lour.) Merr. on the histopathology of the diabetic pancreas via caspase family expression [PDF]

Journal of Pharmacy & Pharmacognosy Research
Context: Diabetes is a prominent cause of mortality globally, particularly in Indonesia. Elevated glucose levels stimulate insulin secretion from pancreatic β cells. A variety of drugs, including oral treatments and synthetic insulin, have been developed
Putri Cahaya Situmorang, Whika Febria Dewatisari, Andina Setyawati, Risma Dumiri Manurung, Eka Setiawan   +4 more
doaj   +1 more source

Inhibitor specificity of recombinant and endogenous caspase-9 [PDF]

Biochemical Journal, 2002
Apoptosis triggered through the intrinsic pathway by radiation and anti-neoplastic drugs is initiated by the activation of caspase-9. To elucidate control mechanisms in this pathway we used a range of synthetic and natural reagents. The inhibitory potency of acetyl-Asp-Glu-Val-Asp-aldehyde ('Ac-DEVD-CHO'), benzyloxycarbonyl-Val-Ala-Asp ...
Ciara A, Ryan, Henning R, Stennicke, Victor E, Nava, Jennifer B, Burch, J Marie, Hardwick, Guy S, Salvesen   +5 more
openaire   +2 more sources

Engineering a dimeric caspase-9: a re-evaluation of the induced proximity model for caspase activation. [PDF]

PLoS Biology, 2005
Caspases are responsible for the execution of programmed cell death (apoptosis) and must undergo proteolytic activation, in response to apoptotic stimuli, to function.
Yang Chao, Eric N Shiozaki, Srinivasa M Srinivasula, Daniel J Rigotti, Robert Fairman, Yigong Shi   +5 more
doaj   +1 more source

Apoptotic Volume Decrease (AVD) Is Independent of Mitochondrial Dysfunction and Initiator Caspase Activation

Cells, 2012
Persistent cell shrinkage is a major hallmark of apoptotic cell death. The early-phase shrinkage, which starts within 30−120 min after apoptotic stimulation and is called apoptotic volume decrease (AVD), is known to be accomplished by activation of K ...
Takeshi Tsubata, Emi Maeno, Yasunobu Okada   +2 more
doaj   +1 more source

Mechanism of zinc‐mediated inhibition of caspase‐9 [PDF]

Protein Science, 2012
AbstractZinc‐mediated inhibition is implicated in global caspase regulation, with relief of zinc‐mediated inhibition central to both small‐molecule and natively induced caspase activation. As an initiator, caspase‐9 regulates the upstream stages of the apoptotic caspase cascade, making it a critical control point.
Kristen L, Huber, Jeanne A, Hardy
openaire   +2 more sources

Oncogene-dependent apoptosis is mediated by caspase-9 [PDF]

Proceedings of the National Academy of Sciences, 1998
Understanding how oncogenic transformation sensitizes cells to apoptosis may provide a strategy to kill tumor cells selectively. We previously developed a cell-free system that recapitulates oncogene dependent apoptosis as reflected by activation of caspases, the core of the apoptotic machinery.
H O, Fearnhead, J, Rodriguez, E E, Govek, W, Guo, R, Kobayashi, G, Hannon, Y A, Lazebnik   +6 more
openaire   +2 more sources