Results 21 to 30 of about 4,575,594 (299)
Indian Journal of Animal Sciences, 2022 The present study was conducted to evaluate the expression of caspase-3, caspase-9, growth differentiation factor-9 (GDF-9) and insulin growth factor-1 (IGF-1) genes in oocytes cultured in vitro with optimum and elevated doses of amphiregulin (50 ng and
RAMESH HONDARAVALLI SOMASHETTY +2 more
doaj +1 more source
Diagnostics, 2021 Ovarian cancer remains a major diagnostic and therapeutic problem in modern gynecological oncology. For this reason, research which focuses on the search for new diagnostic markers and the assessment of their possible usefulness in clinical practice is ...
Aleksandra Mielczarek-Palacz +2 more
doaj +1 more source
Evaluation Expression of the Caspase-3 and Caspase-9 Apoptotic Genes in Schizophrenia Patients. [PDF]
Clin Psychopharmacol Neurosci, 2023 Objective: Apoptosis is programmed cell death that occurs by several pathways. Caspase-3 is induced by active caspase-9 via the intrinsic pathway. The aim of this research was to explore the expression of caspase-3 and caspase-9 in schizophrenia patients
Dirican E +3 more
europepmc +2 more sources
GENETIC POLYMORHISM OF CASPASE 8 AND 9 IN IRAQ
The Iraqi Journal of Agricultural science, 2022 This study examined the potential association between polymorphisms of Caspase 9 −293del (rs4645982) and Caspase8−652 6N ins / del (rs3834129) and the danger of acute and chronic myeloid leukaemia in Iraqi population.
Duaa Abdullah , Reema M. Aloubaidy
doaj +1 more source
Aquaculture and Fisheries, 2021 During low tide intertidal organisms face severe temperature fluctuations. This situation may be more pronounced in the context of climate change.
Fengshen Zhao, Heding Shen
doaj +1 more source
Proteolytic Processing of the Caspase-9 Zymogen Is Required for Apoptosome-mediated Activation of Caspase-9 [PDF]
Journal of Biological Chemistry, 2013 Maturation of the single-chain caspase-9 zymogen through autoproteolytic processing is mediated by the Apaf-1 apoptosome at the onset of apoptosis. Processed caspase-9 and the apoptosome form a holoenzyme with robust proteolytic activity that is 2-3 orders of magnitude higher than that of free processed caspase-9.
Qi, Hu +4 more
openaire +2 more sources
Astaxanthin effect on apoptotic biomarkers in methotrexate-induced liver injury
Al-Mustansiriyah Journal of Pharmaceutical Sciences, 2022 Methotrexate is used in the treatment of cancer, psoriasis, rheumatoid arthritis and several other disorders. It has a hepatotoxic potential side effect. Patients who have no access to alternative medications face a serious challenge as a result.
Sarah Saad Hamdan +2 more
doaj +1 more source
The Apoptosome Activates Caspase-9 by Dimerization [PDF]
Molecular Cell, 2006 The apical protease of the human intrinsic apoptotic pathway, caspase-9, is activated in a polymeric activation platform known as the apoptosome. The mechanism has been debated, and two contrasting hypotheses have been suggested. One of these postulates an allosteric activation of monomeric caspase-9; the other postulates a dimer-driven assembly at the
Pop, Cristina +3 more
openaire +2 more sources
Apoptosis and autophagy: Regulation of caspase‐9 by phosphorylation [PDF]
The FEBS Journal, 2009 Cell death by the process of apoptosis plays important roles in development, tissue homeostasis, diseases and drug responses. The cysteine aspartyl protease caspase‐9 plays a central role in the mitochondrial or intrinsic apoptotic pathway that is engaged in response to many apoptotic stimuli.
Allan, Lindsey A., Clarke, Paul R.
openaire +4 more sources
Regulation of caspase-3 processing by cIAP2 controls the switch between pro-inflammatory activation and cell death in microglia. [PDF]
, 2014 The activation of microglia, resident immune cells of the central nervous system, and inflammation-mediated neurotoxicity are typical features of neurodegenerative diseases, for example, Alzheimer's and Parkinson's diseases. An unexpected role of caspase-
Rodhe, J +11 more
core +1 more source