Results 1 to 10 of about 162,772 (258)
A long way to go: caspase inhibitors in clinical use [PDF]
Cell Death and Disease, 2021 Caspases are an evolutionary conserved family of cysteine-dependent proteases that are involved in many vital cellular processes including apoptosis, proliferation, differentiation and inflammatory response.
Shanel Dhani +2 more
doaj +2 more sources
The Anti-Apoptotic Effects of Caspase Inhibitors in Propyl Gallate-Treated Lung Cancer Cells Are Related to Changes in Reactive Oxygen Species and Glutathione Levels [PDF]
Molecules, 2022 Propyl gallate [3,4,5-trihydroxybenzoic acid propyl ester; PG] exhibits an anti-growth effect in various cells. In this study, the anti-apoptotic effects of various caspase inhibitors were evaluated in PG-treated Calu-6 and A549 lung cancer cells in ...
Woo hyun Park
doaj +2 more sources
Efficient synthesis, biological evaluation, and docking study of isatin based derivatives as caspase inhibitors [PDF]
Journal of Enzyme Inhibition and Medicinal Chemistry, 2020 In this paper, a new series of isatin-sulphonamide based derivatives were designed, synthesised and evaluated as caspase inhibitors. The compounds containing 1-(pyrrolidinyl)sulphonyl and 2-(phenoxymethyl)pyrrolidin-1-yl)sulphonyl substitution at C5 ...
Loghman Firoozpour +10 more
doaj +2 more sources
Cell Death and Differentiation, 1999 Caspases are the key effector molecules of the physiological death process known as apoptosis, although some are involved in activation of cytokines, rather than cell death. They exist in most of our cells as inactive precursors (zymogens) that kill the cell once activated. Caspases can be controlled in two ways.
Paul Ekert, John Silke, David Vaux
exaly +3 more sources
Detection of Caspase Activation In Situ by Fluorochrome-Labeled Caspase Inhibitors [PDF]
BioTechniques, 2001 Apoptosis is dependent on the activation of a group of proteolytic enzymes called caspases. Caspase activation can be detected by immunoblotting using caspase-specific antibodies or by caspase activity measurement employing pro-fluorescent substrates ...
P.A. Amstad +5 more
doaj +3 more sources
Identification of proteasome and caspase inhibitors targeting SARS-CoV-2 Mpro [PDF]
Signal Transduction and Targeted Therapy, 2021 Zhengyuan Wang +9 more
doaj +2 more sources
Caspase inhibitors: prospective therapies for stroke. [PDF]
Neuroscientist, 2013 In ischemic stroke, apoptosis persists for days to weeks after the onset of an ischemic event. Cysteine-ASPartic proteASEs (caspases) are key mediators of apoptosis and neurodegeneration in stroke. The impact of caspase activity is not restricted to neuronal death, as caspases can exacerbate inflammation and alter glial function.
Akpan N, Troy CM.
europepmc +3 more sources
Screening for Caspase-3 Inhibitors: A New Class of Potent Small-Molecule Inhibitors of Caspase-3 [PDF]
Journal of Biomolecular Screening, 2006 From the authors' 650,000 compound collection, they have selected approximately 15,000 potential small-molecule protease inhibitors, which were subjected to high-throughput screening against caspase-3. The screening yielded a series of hits that belong to 11 different scaffolds.
Dmitry Kravchenko +2 more
exaly +3 more sources
Caspase inhibitors: viral, cellular and chemical [PDF]
Cell Death and Differentiation, 2006 Caspases, key mediators of apoptosis, are a structurally related family of cysteine proteases that cleave their substrates at aspartic acid residues either to cause cell death or to activate cytokines as part of an immune response. They can be controlled upstream by the regulation of signals that lead to zymogen activation, or downstream by inhibitors ...
David Vaux, Vaux D L
exaly +3 more sources
Pharmaceuticals, 2021 Due to their potential in the treatment of neurodegenerative diseases, caspase-6 inhibitors have attracted widespread attention. However, the existing caspase-6 inhibitors showed more or less inevitable deficiencies that restrict their clinical ...
Shuheng Huang +8 more
doaj +1 more source