Results 11 to 20 of about 162,682 (253)

A long way to go: caspase inhibitors in clinical use [PDF]

Cell Death and Disease, 2021
Caspases are an evolutionary conserved family of cysteine-dependent proteases that are involved in many vital cellular processes including apoptosis, proliferation, differentiation and inflammatory response.
Shanel Dhani, Yun Zhao, Boris Zhivotovsky   +2 more
doaj   +2 more sources

The Anti-Apoptotic Effects of Caspase Inhibitors in Propyl Gallate-Treated Lung Cancer Cells Are Related to Changes in Reactive Oxygen Species and Glutathione Levels [PDF]

Molecules, 2022
Propyl gallate [3,4,5-trihydroxybenzoic acid propyl ester; PG] exhibits an anti-growth effect in various cells. In this study, the anti-apoptotic effects of various caspase inhibitors were evaluated in PG-treated Calu-6 and A549 lung cancer cells in ...
Woo hyun Park
doaj   +2 more sources

Efficient synthesis, biological evaluation, and docking study of isatin based derivatives as caspase inhibitors [PDF]

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
In this paper, a new series of isatin-sulphonamide based derivatives were designed, synthesised and evaluated as caspase inhibitors. The compounds containing 1-(pyrrolidinyl)sulphonyl and 2-(phenoxymethyl)pyrrolidin-1-yl)sulphonyl substitution at C5 ...
Loghman Firoozpour, Lixin Gao, Setareh Moghimi, Parvin Pasalar, Jamshid Davoodi, Ming-Wei Wang, Zahra Rezaei, Armin Dadgar, Hoda Yahyavi, Massoud Amanlou, Alireza Foroumadi   +10 more
doaj   +2 more sources

Detection of Caspase Activation In Situ by Fluorochrome-Labeled Caspase Inhibitors [PDF]

BioTechniques, 2001
Apoptosis is dependent on the activation of a group of proteolytic enzymes called caspases. Caspase activation can be detected by immunoblotting using caspase-specific antibodies or by caspase activity measurement employing pro-fluorescent substrates ...
P.A. Amstad, G. Yu, G.L. Johnson, B.W. Lee, S. Dhawan, D.J. Phelps   +5 more
doaj   +3 more sources

Identification of proteasome and caspase inhibitors targeting SARS-CoV-2 Mpro [PDF]

Signal Transduction and Targeted Therapy, 2021
Zhengyuan Wang, Yao Zhao, Qingxing Wang, Yangfei Xing, Lu Feng, Juan Kong, Chao Peng, Leike Zhang, Haitao Yang, Min Lu   +9 more
doaj   +2 more sources

De Novo Molecular Design of Caspase-6 Inhibitors by a GRU-Based Recurrent Neural Network Combined with a Transfer Learning Approach

Pharmaceuticals, 2021
Due to their potential in the treatment of neurodegenerative diseases, caspase-6 inhibitors have attracted widespread attention. However, the existing caspase-6 inhibitors showed more or less inevitable deficiencies that restrict their clinical ...
Shuheng Huang, Hu Mei, Laichun Lu, Minyao Qiu, Xiaoqi Liang, Lei Xu, Zuyin Kuang, Yu Heng, Xianchao Pan   +8 more
doaj   +1 more source

Caspase Substrates and Inhibitors [PDF]

Cold Spring Harbor Perspectives in Biology, 2013
Caspases are proteases at the heart of networks that govern apoptosis and inflammation. The past decade has seen huge leaps in understanding the biology and chemistry of the caspases, largely through the development of synthetic substrates and inhibitors.
Marcin, Poreba, Aleksandra, Strózyk, Guy S, Salvesen, Marcin, Drag   +3 more
openaire   +2 more sources

Contribution of caspase(s) to the cell cycle regulation at mitotic phase. [PDF]

PLoS ONE, 2011
Caspases have been suggested to contribute to not only apoptosis regulation but also non-apoptotic cellular phenomena. Recently, we have reported the involvement of caspase-7 to the cell cycle progression at mitotic phase by knockdown of caspase-7 using ...
Toshiaki Hashimoto, Ushio Kikkawa, Shinji Kamada   +2 more
doaj   +1 more source

Peptides Targeting Caspase Inhibitors [PDF]

Journal of Biological Chemistry, 2003
Here we report on the identification of peptides targeting the X-inhibitor of apoptosis protein (XIAP). XIAP functions as a caspase inhibitor and is a member of the inhibitors of apoptosis (IAP) family of proteins. IAPs are often overexpressed in cancers and leukemias and are associated with an unfavorable clinical prognosis.
Tamm, Ingo, Trepel, Martin, Cardó-Vila, Marina, Sun, Yan, Welsh, Kate, Cabezas, Edelmira, Swatterthwait, Arnold, Arap, Wadih, Reed, John C., Pasqualini, Renata   +9 more
openaire   +4 more sources

Selection of Efficient Inhibitors for Caspas-9 according to Structure-Based Pharmacophore Screening Strategy and Molecular Dynamics Simulations

Trends in Peptide and Protein Sciences, 2020
Caspases are enzymes which are the main pathways for apoptosis. Any irregulation in their functions causes increase or decrease in cell death, which result in autoimmune disease or cancer, respectively.
Samira Ansari, Ali Naghi Kamali, Kowsar Bagherzadeh, Masoud Amanlou, Sajjad Aghabalazadeh   +4 more
doaj   +1 more source