Results 11 to 20 of about 162,772 (258)

Contribution of caspase(s) to the cell cycle regulation at mitotic phase. [PDF]

PLoS ONE, 2011
Caspases have been suggested to contribute to not only apoptosis regulation but also non-apoptotic cellular phenomena. Recently, we have reported the involvement of caspase-7 to the cell cycle progression at mitotic phase by knockdown of caspase-7 using ...
Toshiaki Hashimoto, Ushio Kikkawa, Shinji Kamada   +2 more
doaj   +1 more source

Caspase Substrates and Inhibitors [PDF]

Cold Spring Harbor Perspectives in Biology, 2013
Caspases are proteases at the heart of networks that govern apoptosis and inflammation. The past decade has seen huge leaps in understanding the biology and chemistry of the caspases, largely through the development of synthetic substrates and inhibitors.
Marcin, Poreba, Aleksandra, Strózyk, Guy S, Salvesen, Marcin, Drag   +3 more
openaire   +2 more sources

Peptides Targeting Caspase Inhibitors [PDF]

Journal of Biological Chemistry, 2003
Here we report on the identification of peptides targeting the X-inhibitor of apoptosis protein (XIAP). XIAP functions as a caspase inhibitor and is a member of the inhibitors of apoptosis (IAP) family of proteins. IAPs are often overexpressed in cancers and leukemias and are associated with an unfavorable clinical prognosis.
Tamm, Ingo, Trepel, Martin, Cardó-Vila, Marina, Sun, Yan, Welsh, Kate, Cabezas, Edelmira, Swatterthwait, Arnold, Arap, Wadih, Reed, John C., Pasqualini, Renata   +9 more
openaire   +4 more sources

Selection of Efficient Inhibitors for Caspas-9 according to Structure-Based Pharmacophore Screening Strategy and Molecular Dynamics Simulations

Trends in Peptide and Protein Sciences, 2020
Caspases are enzymes which are the main pathways for apoptosis. Any irregulation in their functions causes increase or decrease in cell death, which result in autoimmune disease or cancer, respectively.
Samira Ansari, Ali Naghi Kamali, Kowsar Bagherzadeh, Masoud Amanlou, Sajjad Aghabalazadeh   +4 more
doaj   +1 more source

Mechanistic and structural understanding of uncompetitive inhibitors of caspase-6. [PDF]

PLoS ONE, 2012
Inhibition of caspase-6 is a potential therapeutic strategy for some neurodegenerative diseases, but it has been difficult to develop selective inhibitors against caspases.
Christopher E Heise, Jeremy Murray, Katherine E Augustyn, Brandon Bravo, Preeti Chugha, Frederick Cohen, Anthony M Giannetti, Paul Gibbons, Rami N Hannoush, Brian R Hearn, Priyadarshini Jaishankar, Cuong Q Ly, Kinjalkumar Shah, Karen Stanger, Micah Steffek, Yinyan Tang, Xianrui Zhao, Joseph W Lewcock, Adam R Renslo, John Flygare, Michelle R Arkin   +20 more
doaj   +1 more source

Mitochondrial Permeability Transition Causes Mitochondrial Reactive Oxygen Species- and Caspase 3-Dependent Atrophy of Single Adult Mouse Skeletal Muscle Fibers

Cells, 2021
Elevated mitochondrial reactive oxygen species (mROS) and an increase in caspase-3 activity are established mechanisms that lead to skeletal muscle atrophy via the upregulation of protein degradation pathways.
Sarah K. Skinner, Angelo Solania, Dennis W. Wolan, Michael S. Cohen, Terence E. Ryan, Russell T. Hepple   +5 more
doaj   +1 more source

Identification and functional characterization of SlDronc in Spodoptera littoralis [PDF]

PeerJ, 2020
Background Apoptosis is responsible for eliminating damaged and virus-infected cells, regulating normal cell turnover, and maintaining the immune system’s development and function.
Hao Liu, Ke Zhou, Zhouning Yang
doaj   +2 more sources

A whole cell assay to measure caspase-6 activity by detecting cleavage of lamin A/C. [PDF]

PLoS ONE, 2012
Caspase-6 is a cysteinyl protease implicated in neurodegenerative conditions including Alzheimer's and Huntington's disease making it an attractive target for therapeutic intervention.
Robert Mintzer, Sreemathy Ramaswamy, Kinjalkumar Shah, Rami N Hannoush, Christine D Pozniak, Frederick Cohen, Xianrui Zhao, Emile Plise, Joseph W Lewcock, Christopher E Heise   +9 more
doaj   +1 more source

Caspase-Dependent Apoptosis Induced by Telomere Cleavage and TRF2 Loss

Neoplasia: An International Journal for Oncology Research, 2000
Chromosomal abnormalities involving telomeric associations (TAs) often precede replicative senescence and abnormal chromosome configurations. We report here that telomere cleavage following exposure to proapoptotic agents is an early event in apoptosis ...
Asha S. Multani, Mustafa Ozen, Satya Narayad, Virendra Kumar, Joya Chandra, David J. McConkey, Robert A. Newman, Sen Pathak   +7 more
doaj   +1 more source

A Fluorescence-Polarization-Based Lipopolysaccharide–Caspase-4 Interaction Assay for the Development of Inhibitors

Molecules, 2022
Recognition of intracellular lipopolysaccharide (LPS) by Caspase-4 (Casp-4) is critical for host defense against Gram-negative pathogens. LPS binds to the N-terminal caspase activation and recruitment domain (CARD) of procaspase-4, leading to auto ...
Jinsu An, So Yeon Kim, Eun Gyeong Yang, Hak Suk Chung   +3 more
doaj   +1 more source