Results 31 to 40 of about 162,772 (258)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Effects of Caspase Inhibitors on Hematopoietic Engraftment after Short-Term Culture

Cell Transplantation, 2002
The induction of apoptosis during cytokine-induced proliferation of hematopoietic stem and progenitor cells (HSPC) may result in the loss of hematopoietic function. We tested the ability of several caspase inhibitors to maintain transplantation potential
Anne Wiesmann, A. Elena Searles, L. Jeanne Pierce, Gerald J. Spangrude   +3 more
doaj   +1 more source

Roles of Bcl-2 and caspase-9 and -3 in CD30-induced human eosinophil apoptosis

Journal of Microbiology, Immunology and Infection, 2017
Background/purpose: Activation of cell surface CD30 by immobilized anti-CD30 monoclonal antibodies (mAb) induces strong apoptosis in human eosinophils.
Hye Jin Lee, Eun-Kyoung Lee, Young Eun Seo, Youn Ho Shin, Hwan Soo Kim, Yoon Hong Chun, Jong-Seo Yoon, Hyun Hee Kim, Man Yong Han, Chang-Keun Kim, Kyu-Earn Kim, Young Yull Koh, Jin Tack Kim   +12 more
doaj   +1 more source

Caspase Inhibition as a Possible Therapeutic Strategy for Pemphigus Vulgaris: A Systematic Review of Current Evidence

Biology, 2022
Background: Pemphigus vulgaris (PV) is an IgG-mediated autoimmune disease characterised by epithelial cell–cell detachment (acantholysis) resulting in mucocutaneous blistering.
Sanna Huda, Bethany Chau, Chuanqi Chen, Herman Somal, Neiloy Chowdhury, Nicola Cirillo   +5 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

RIPK1 Mediates TNF-Induced Intestinal Crypt Apoptosis During Chronic NF-κB ActivationSummary

Cellular and Molecular Gastroenterology and Hepatology, 2020
Background and Aims: Tumor necrosis factor (TNF) is a major pathogenic effector and a therapeutic target in inflammatory bowel disease (IBD), yet the basis for TNF-induced intestinal epithelial cell (IEC) death is unknown, because TNF does not kill ...
Jerry Wong, Ricard Garcia-Carbonell, Matija Zelic, Samuel B. Ho, Brigid S. Boland, Shih-Jing Yao, Shalin A. Desai, Soumita Das, Núria Planell, Philip A. Harris, Joan Font-Burgada, Koji Taniguchi, John Bertin, Azucena Salas, Manolis Pasparakis, Pete J. Gough, Michelle Kelliher, Michael Karin, Monica Guma   +18 more
doaj   +1 more source

Caspase-8: Friend or Foe in Bortezomib/Lenalidomide-Based Therapy for Myeloma

Frontiers in Oncology, 2022
Antiproliferation and proapoptosis are two major molecular mechanisms of action of drugs used for the treatment of multiple myeloma. Proteasome inhibitors, such as bortezomib (PS-341), and immunomodulatory drugs (IMiDs), such as lenalidomide, are the two
Liang Zhou
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

The anti-apoptotic activity of BAG3 is restricted by caspases and the proteasome. [PDF]

PLoS ONE, 2009
Caspase-mediated cleavage and proteasomal degradation of ubiquitinated proteins are two independent mechanisms for the regulation of protein stability and cellular function. We previously reported BAG3 overexpression protected ubiquitinated clients, such
Victoria M Virador, Ben Davidson, Josephine Czechowicz, Alisha Mai, Jareer Kassis, Elise C Kohn   +5 more
doaj   +1 more source