Results 31 to 40 of about 162,682 (253)

Caspase Inhibitors for the Treatment of Hepatitis C [PDF]

Clinics in Liver Disease, 2009
Decreasing hepatocyte injury and death is an attractive therapeutic target in chronic hepatitis C and other liver diseases. Apoptotic cell death is a critical mechanism responsible for liver injury in hepatitis C, and contributes to hepatic fibrogenesis.
Howard C, Masuoka, Maria Eugenia, Guicciardi, Gregory J, Gores   +2 more
openaire   +2 more sources

The roles of p38MAPK and caspase-3 in DADS-induced apoptosis in human HepG2 cells

Journal of Experimental & Clinical Cancer Research, 2010
Objectives To explore the function of p38MAPK and caspase-3 in DADS-induced apoptosis in human HepG2 cells, and discuss the signal transduetion mechanism of HepG2 cells in the apoptosis process induced by DADS by using the inhibitors of p38MAPK (SB203580)
Ma Heng, Ren Fenglian, Ji Chunxiao, Xu Ming   +3 more
doaj   +1 more source

Double-Edged Sword Effect of Pyroptosis: The Role of Caspase-1/-4/-5/-11 in Different Levels of Apical Periodontitis

Biomolecules, 2022
The study was to investigate the effect of canonical and noncanonical pyroptosis in apical periodontitis. Proteins’ profiles of human apical periodontitis tissue were analyzed by label-free proteomics.
Zhiwu Wu, Mingming Li, Xiaolin Ren, Rui Zhang, Jinfeng He, Li Cheng, Ran Cheng, Tao Hu   +7 more
doaj   +1 more source

A calpain inhibitor protects against fractalkine production in lipopolysaccharide-treated endothelial cells

Kidney Research and Clinical Practice, 2017
Background: Fractalkine (CX3CL1) is a chemokine with a unique CX3C motif and is produced by endothelial cells stimulated with lipopolysaccharide (LPS), tumor necrosis factor (TNF)-α, interleukin (IL)-1, and interferon-γ.
Jaewoong Jang, Yoosik Yoon, Dong-Jin Oh
doaj   +1 more source

Targeting Caspase 8: Using Structural and Ligand-Based Approaches to Identify Potential Leads for the Treatment of Multi-Neurodegenerative Diseases

Molecules, 2019
Caspase 8 is a central player in the apoptotic cell death pathway and is also essential for cytokine processing. The critical role of this protease in cell death pathways has generated research interest because its activation has also been linked with ...
Khurshid Ahmad, Vishal M. Balaramnavar, Navaneet Chaturvedi, Saif Khan, Shafiul Haque, Yong-Ho Lee, Inho Choi   +6 more
doaj   +1 more source

Substrate and Inhibitor-induced Dimerization and Cooperativity in Caspase-1 but Not Caspase-3 [PDF]

Journal of Biological Chemistry, 2013
Caspases are intracellular cysteine-class proteases with aspartate specificity that is critical for driving processes as diverse as the innate immune response and apoptosis, exemplified by caspase-1 and caspase-3, respectively. Interestingly, caspase-1 cleaves far fewer cellular substrates than caspase-3 and also shows strong positive cooperativity ...
Datta, Debajyoti, McClendon, Christopher L, Jacobson, Matthew P, Wells, James A   +3 more
openaire   +4 more sources

Small Molecules for the Treatment of Long-COVID-Related Vascular Damage and Abnormal Blood Clotting: A Patent-Based Appraisal

Viruses
People affected by COVID-19 are exposed to, among others, abnormal clotting and endothelial dysfunction, which may result in deep vein thrombosis, cerebrovascular disorders, and ischemic and non-ischemic heart diseases, to mention a few.
Francesco Samarelli, Giovanni Graziano, Nicola Gambacorta, Elisabetta Anna Graps, Francesco Leonetti, Orazio Nicolotti, Cosimo Damiano Altomare   +6 more
doaj   +1 more source

Reassessment of Caspase Inhibition to Augment Grafted Dopamine Neuron Survival

Cell Transplantation, 2004
One experimental therapy for Parkinson's disease (PD) is the transplantation of embryonic ventral mesencephalic tissue. Unfortunately, up to 95% of grafted neurons die, many via apoptosis.
Deanna M. Marchionini, Timothy J. Collier, Mark R. Pitzer, Caryl E. Sortwell   +3 more
doaj   +1 more source

Caspase Inhibition as a Possible Therapeutic Strategy for Pemphigus Vulgaris: A Systematic Review of Current Evidence

Biology, 2022
Background: Pemphigus vulgaris (PV) is an IgG-mediated autoimmune disease characterised by epithelial cell–cell detachment (acantholysis) resulting in mucocutaneous blistering.
Sanna Huda, Bethany Chau, Chuanqi Chen, Herman Somal, Neiloy Chowdhury, Nicola Cirillo   +5 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source