Results 21 to 30 of about 162,682 (253)

Mechanistic and structural understanding of uncompetitive inhibitors of caspase-6. [PDF]

PLoS ONE, 2012
Inhibition of caspase-6 is a potential therapeutic strategy for some neurodegenerative diseases, but it has been difficult to develop selective inhibitors against caspases.
Christopher E Heise, Jeremy Murray, Katherine E Augustyn, Brandon Bravo, Preeti Chugha, Frederick Cohen, Anthony M Giannetti, Paul Gibbons, Rami N Hannoush, Brian R Hearn, Priyadarshini Jaishankar, Cuong Q Ly, Kinjalkumar Shah, Karen Stanger, Micah Steffek, Yinyan Tang, Xianrui Zhao, Joseph W Lewcock, Adam R Renslo, John Flygare, Michelle R Arkin   +20 more
doaj   +1 more source

Identification and functional characterization of SlDronc in Spodoptera littoralis [PDF]

PeerJ, 2020
Background Apoptosis is responsible for eliminating damaged and virus-infected cells, regulating normal cell turnover, and maintaining the immune system’s development and function.
Hao Liu, Ke Zhou, Zhouning Yang
doaj   +2 more sources

Mitochondrial Permeability Transition Causes Mitochondrial Reactive Oxygen Species- and Caspase 3-Dependent Atrophy of Single Adult Mouse Skeletal Muscle Fibers

Cells, 2021
Elevated mitochondrial reactive oxygen species (mROS) and an increase in caspase-3 activity are established mechanisms that lead to skeletal muscle atrophy via the upregulation of protein degradation pathways.
Sarah K. Skinner, Angelo Solania, Dennis W. Wolan, Michael S. Cohen, Terence E. Ryan, Russell T. Hepple   +5 more
doaj   +1 more source

A whole cell assay to measure caspase-6 activity by detecting cleavage of lamin A/C. [PDF]

PLoS ONE, 2012
Caspase-6 is a cysteinyl protease implicated in neurodegenerative conditions including Alzheimer's and Huntington's disease making it an attractive target for therapeutic intervention.
Robert Mintzer, Sreemathy Ramaswamy, Kinjalkumar Shah, Rami N Hannoush, Christine D Pozniak, Frederick Cohen, Xianrui Zhao, Emile Plise, Joseph W Lewcock, Christopher E Heise   +9 more
doaj   +1 more source

Inhibition of distant caspase homologues by natural caspase inhibitors [PDF]

Biochemical Journal, 2001
Caspases play an important role in the ability of animal cells to kill themselves by apoptosis. Caspase activity is regulated in vivo by members of three distinct protease inhibitor families, two of which, baculovirus p35 and members of the inhibitor of apoptosis (IAP) family, are thought to be caspase specific.
Snipas, Scott J., Stennicke, Henning R., Riedl, Stefan, Potempa, Jan, Travis, James, Barrett, Alan J., Salvesen, Guy S.   +6 more
openaire   +3 more sources

Caspase-Dependent Apoptosis Induced by Telomere Cleavage and TRF2 Loss

Neoplasia: An International Journal for Oncology Research, 2000
Chromosomal abnormalities involving telomeric associations (TAs) often precede replicative senescence and abnormal chromosome configurations. We report here that telomere cleavage following exposure to proapoptotic agents is an early event in apoptosis ...
Asha S. Multani, Mustafa Ozen, Satya Narayad, Virendra Kumar, Joya Chandra, David J. McConkey, Robert A. Newman, Sen Pathak   +7 more
doaj   +1 more source

Apoptosis inhibitor 5 is an endogenous inhibitor of caspase‐2 [PDF]

EMBO reports, 2017
Caspases are key enzymes responsible for mediating apoptotic cell death. Across species, caspase-2 is the most conserved caspase and stands out due to unique features. Apart from cell death, caspase-2 also regulates autophagy, genomic stability and ageing. Caspase-2 requires dimerization for its activation which is primarily accomplished by recruitment
Gergely Imre, Jean Berthelet, Jan Heering, Sebastian Kehrloesser, Inga Maria Melzer, Byung Il Lee, Bernd Thiede, Volker Dötsch, Krishnaraj Rajalingam   +8 more
openaire   +4 more sources

A Fluorescence-Polarization-Based Lipopolysaccharide–Caspase-4 Interaction Assay for the Development of Inhibitors

Molecules, 2022
Recognition of intracellular lipopolysaccharide (LPS) by Caspase-4 (Casp-4) is critical for host defense against Gram-negative pathogens. LPS binds to the N-terminal caspase activation and recruitment domain (CARD) of procaspase-4, leading to auto ...
Jinsu An, So Yeon Kim, Eun Gyeong Yang, Hak Suk Chung   +3 more
doaj   +1 more source

Immunogenic cell death after combined treatment with radiation and ATR inhibitors is dually regulated by apoptotic caspases

Frontiers in Immunology, 2023
IntroductionInhibitors of the ATR kinase act as radiosensitizers through abrogating the G2 checkpoint and reducing DNA repair. Recent studies suggest that ATR inhibitors can also increase radiation-induced antitumor immunity, but the underlying ...
Adrian Eek Mariampillai, Adrian Eek Mariampillai, Sissel Hauge, Karoline Kongsrud, Randi G. Syljuåsen   +4 more
doaj   +1 more source

Autolysosomes and caspase-3 control the biogenesis and release of immunogenic apoptotic exosomes

Cell Death and Disease, 2022
Apoptotic exosome-like vesicles (ApoExos) are a novel type of extracellular vesicle that contribute to the propagation of inflammation at sites of vascular injury when released by dying cells.
Déborah Beillevaire, Francis Migneault, Julie Turgeon, Diane Gingras, Annie Karakeussian Rimbaud, Geneviève Marcoux, Crysta Spino, Nicolas Thibodeau, Eric Bonneil, Pierre Thibault, Éric Boilard, Mélanie Dieudé, Marie-Josée Hébert   +12 more
doaj   +1 more source