Results 21 to 30 of about 162,772 (258)
Frontiers in Immunology, 2023 IntroductionInhibitors of the ATR kinase act as radiosensitizers through abrogating the G2 checkpoint and reducing DNA repair. Recent studies suggest that ATR inhibitors can also increase radiation-induced antitumor immunity, but the underlying ...
Adrian Eek Mariampillai +4 more
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Autolysosomes and caspase-3 control the biogenesis and release of immunogenic apoptotic exosomes
Cell Death and Disease, 2022 Apoptotic exosome-like vesicles (ApoExos) are a novel type of extracellular vesicle that contribute to the propagation of inflammation at sites of vascular injury when released by dying cells.
Déborah Beillevaire +12 more
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Biomolecules, 2022 The study was to investigate the effect of canonical and noncanonical pyroptosis in apical periodontitis. Proteins’ profiles of human apical periodontitis tissue were analyzed by label-free proteomics.
Zhiwu Wu +7 more
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Inhibition of distant caspase homologues by natural caspase inhibitors [PDF]
Biochemical Journal, 2001 Caspases play an important role in the ability of animal cells to kill themselves by apoptosis. Caspase activity is regulated in vivo by members of three distinct protease inhibitor families, two of which, baculovirus p35 and members of the inhibitor of apoptosis (IAP) family, are thought to be caspase specific.
Snipas, Scott J. +6 more
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The roles of p38MAPK and caspase-3 in DADS-induced apoptosis in human HepG2 cells
Journal of Experimental & Clinical Cancer Research, 2010 Objectives To explore the function of p38MAPK and caspase-3 in DADS-induced apoptosis in human HepG2 cells, and discuss the signal transduetion mechanism of HepG2 cells in the apoptosis process induced by DADS by using the inhibitors of p38MAPK (SB203580)
Ma Heng +3 more
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Kidney Research and Clinical Practice, 2017 Background: Fractalkine (CX3CL1) is a chemokine with a unique CX3C motif and is produced by endothelial cells stimulated with lipopolysaccharide (LPS), tumor necrosis factor (TNF)-α, interleukin (IL)-1, and interferon-γ.
Jaewoong Jang, Yoosik Yoon, Dong-Jin Oh
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Molecules, 2019 Caspase 8 is a central player in the apoptotic cell death pathway and is also essential for cytokine processing. The critical role of this protease in cell death pathways has generated research interest because its activation has also been linked with ...
Khurshid Ahmad +6 more
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VirusesPeople affected by COVID-19 are exposed to, among others, abnormal clotting and endothelial dysfunction, which may result in deep vein thrombosis, cerebrovascular disorders, and ischemic and non-ischemic heart diseases, to mention a few.
Francesco Samarelli +6 more
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Reassessment of Caspase Inhibition to Augment Grafted Dopamine Neuron Survival
Cell Transplantation, 2004 One experimental therapy for Parkinson's disease (PD) is the transplantation of embryonic ventral mesencephalic tissue. Unfortunately, up to 95% of grafted neurons die, many via apoptosis.
Deanna M. Marchionini +3 more
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Apoptosis inhibitor 5 is an endogenous inhibitor of caspase‐2 [PDF]
The EMBO Reports, 2017 Caspases are key enzymes responsible for mediating apoptotic cell death. Across species, caspase-2 is the most conserved caspase and stands out due to unique features. Apart from cell death, caspase-2 also regulates autophagy, genomic stability and ageing. Caspase-2 requires dimerization for its activation which is primarily accomplished by recruitment
Gergely Imre +8 more
openaire +4 more sources