Results 31 to 40 of about 7,578,422 (291)
Functions of caspase 8: The identified and the mysterious [PDF]
Seminars in Immunology, 2014 Initially discovered as an initiator protease in apoptosis mediated by death receptors, caspase-8 is now known to have an apparently confounding opposing effect in securing cell survival. It is required to allow mouse embryo survival, and the survival of hematopoietic cells during their development and activation.
Salvesen, Guy S, Walsh, Craig M
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Cell Death and Disease, 2021 Caspase-8 is a unique member of caspases with a dual role in cell death and survival. Caspase-8 expression is often lost in some tumors, but increased in others, indicating a potential pro-survival function in cancer.
Jia Xia +10 more
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Caspase-8 RNA half-life and CpG positions on its promoter proximal region.
, 2022 (A) Quantification of caspase-8 mRNA to check its half-life post transcriptional block (using Actinomycin-D) (n = 3). (B) In situ hybridization with anti-sense and sense probe of caspase-8 RNA (in vitro) [scale = 10 μm].
Akshay Hegde (13813404) +7 more
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Irisin Protects Against Hind Limb Ischemia Reperfusion Injury
Drug Design, Development and Therapy, 2021 Ayşegül Küçük,1,* Yücel Polat,2 Aydan Kılıçarslan,3 Nuran Süngü,3 Hakan Kartal,4 Ali Doğan Dursun,5,* Mustafa Arslan6 1Kutahya Health Sciences University, Medical Faculty, Department of Physiology, Kutahya ...
Küçük A +6 more
doaj
Neurobiology of Disease, 2003 Abnormal Tau protein is known to be closely associated with several neurodegenerative diseases. Previously, we showed that Tau was cleaved by caspase-3 to generate the cleavage product lacking the C-terminus (ΔTau-1) during neuronal cell death.
Chul-Woong Chung +6 more
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Caspase-8 content in SNU-1 cells.
, 2021 Increases in intracellular Caspase-8 compared to blank (untreated) SNU-1 cells upon treatment with 50–5000 nm sized aminated, carboxylated and NF particles for 4 h. Data compared with respect to surface functionalization (A) or particle size (B).
Amrita Banerjee (382658) +2 more
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Downregulation of Caspase 8 in a group of Iranian breast cancer patients – A pilot study
Journal of the Egyptian National Cancer Institute, 2017 Purpose: It is now well known that evading apoptosis, as a cancer hallmark, can lead to tumour initiation, progression and metastasis. As a result of genome wide association studies, an initiator protease in this pathway, caspase 8 (CASP8), has been ...
Masoumeh Aghababazadeh +5 more
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Caspase‐8 Variant G Regulates Rheumatoid Arthritis Fibroblast‐Like Synoviocyte Aggressive Behavior
ACR Open Rheumatology, 2022 Objective Fibroblast‐like synoviocytes (FLS) play a pivotal role in rheumatoid arthritis (RA) by contributing to synovial inflammation and progressive joint damage. An imprinted epigenetic state is associated with the FLS aggressive phenotype.
Cecilia Ansalone +15 more
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Neurobiology of Disease, 2021 Retinal ganglion cells (RGCs) expanding from the retina to the brain are primary victims of neurodegeneration in glaucoma, a leading cause of blindness; however, the neighboring astroglia survive the glaucoma-related stress and promote neuroinflammation.
Xiangjun Yang, Qun Zeng, Gülgün Tezel
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Caspase 8: igniting the death machine [PDF]
Structure, 1999 Intense research into the signaling pathways of apoptosis has revealed a dominant role for proteases belonging to the caspase family, which in humans has 11 members at present. Two papers in the September issue of Structure with Folding & Design have for the first time revealed the structure of the key apoptotic initiator, caspase 8.
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