Results 31 to 40 of about 5,538,011 (302)
Journal of Translational Autoimmunity, 2020 Glucocorticoids promote thymocyte apoptosis and modulate transcription of numerous regulators of thymic apoptosis. Among these, glucocorticoid-induced leucine zipper (GILZ) is strongly upregulated in the thymus.
Isabella Muscari +8 more
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Caspase-8 is upstream of caspase-1 in the death pathway of Ripk1D325A/D325A mice at E10.5.
, 2021 (A and B) IF staining of E10.5 YS with anti-PECAM (red) and anti-Cl.CASP1 (green) antibodies. Scale bars, 50 μm. Images are representative of 4 embryos per genotype.
Ye-hsuan Sun (11338002) +12 more
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Tyrosine Phosphorylation of Caspase-8 Abrogates Its Apoptotic Activity and Promotes Activation of c-Src. [PDF]
PLoS ONE, 2016 Src family tyrosine kinases (SFKs) phosphorylate caspase-8A at tyrosine (Y) 397 resulting in suppression of apoptosis. In addition, the phosphorylation of caspase-8A at other sites including Y465 has been implicated in the regulation of caspase-8 ...
Jennifer Ly Tsang +8 more
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Functions of caspase 8: The identified and the mysterious [PDF]
Seminars in Immunology, 2014 Initially discovered as an initiator protease in apoptosis mediated by death receptors, caspase-8 is now known to have an apparently confounding opposing effect in securing cell survival. It is required to allow mouse embryo survival, and the survival of hematopoietic cells during their development and activation.
Salvesen, Guy S, Walsh, Craig M
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Caspase-8 mediates optimal cell death independently of its autocleavage downstream of TNF signaling.
, 2023 (A-B) WT (B), Ripk3-/-, Ripk3-/-Casp8-/-, and Ripk3-/-Casp8DA BMDMs were primed with either 10 ng/mL rTNF or PBS mock control for 16 hours prior to infection with non-replicating (A) or replicating (B) ΔflaA L. pneumophila at MOI = 10 (A) or 1 (B) for 8 (
Víctor R. Vázquez Marrero (16033149) +3 more
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Irisin Protects Against Hind Limb Ischemia Reperfusion Injury
Drug Design, Development and Therapy, 2021 Ayşegül Küçük,1,* Yücel Polat,2 Aydan Kılıçarslan,3 Nuran Süngü,3 Hakan Kartal,4 Ali Doğan Dursun,5,* Mustafa Arslan6 1Kutahya Health Sciences University, Medical Faculty, Department of Physiology, Kutahya ...
Küçük A +6 more
doaj
Neurobiology of Disease, 2003 Abnormal Tau protein is known to be closely associated with several neurodegenerative diseases. Previously, we showed that Tau was cleaved by caspase-3 to generate the cleavage product lacking the C-terminus (ΔTau-1) during neuronal cell death.
Chul-Woong Chung +6 more
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Cell Death and Disease, 2021 Caspase-8 is a unique member of caspases with a dual role in cell death and survival. Caspase-8 expression is often lost in some tumors, but increased in others, indicating a potential pro-survival function in cancer.
Jia Xia +10 more
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TNF receptors regulate vascular homeostasis in zebrafish through a caspase-8, caspase-2 and P53 apoptotic program that bypasses caspase-3 [PDF]
, 2013 Although it is known that tumor necrosis factor receptor (TNFR) signaling plays a crucial role in vascular integrity and homeostasis, the contribution of each receptor to these processes and the signaling pathway involved are still largely unknown. Here,
Sergio Candel +21 more
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Caspase 8: igniting the death machine [PDF]
Structure, 1999 Intense research into the signaling pathways of apoptosis has revealed a dominant role for proteases belonging to the caspase family, which in humans has 11 members at present. Two papers in the September issue of Structure with Folding & Design have for the first time revealed the structure of the key apoptotic initiator, caspase 8.
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