Results 11 to 20 of about 307,665 (262)
Activation of the NLRP1B inflammasome by caspase-8 [PDF]
Communications BiologyCleavage of the innate immune receptor NLRP1B by various microbial proteases causes the proteasomal degradation of its N-terminal fragment and the subsequent release of a C-terminal fragment that forms an inflammasome.
Justin J. Meade +5 more
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NLK facilitates Caspase‐8 activation to drive macrophage PANoptosis in sepsis [PDF]
Clinical and Translational MedicineMounting evidence indicates that macrophage PANoptosis—an integrated inflammatory cell‐death program comprising pyroptosis, apoptosis, and necroptosis—plays a pivotal role in sepsis pathogenesis. However, its upstream regulation remains poorly understood.
Yun Xia +17 more
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Loss of DNA methyltransferase 3a enhances Caspase-8 transcription and promotes cardiomyocyte pyroptosis during myocardial infarction [PDF]
Nature CommunicationsAspartate-specific cysteine protease (Caspase)-8 plays a critical role in initiating pyroptosis by mediating cleavage and activation of gasdermin-D (Gsdmd) during Yersinia infection.
Ning Wang +24 more
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Biomimetic dual-crosslinked GelMA-SilMA hydrogel microneedle for delivering DSPE-PEG2K-TAT-modified quercetin liposomes to treat rheumatoid arthritis via the caspase-8/caspase-3/GSDME pathway [PDF]
Journal of NanobiotechnologyRheumatoid arthritis (RA) is a chronic inflammatory disease characterized by synovitis, whose pathogenesis remains unclear. Fibroblast-like synoviocytes (FLS) are central to the pathogenesis and progression of RA. This study aims to investigate the novel
Qingcong Zheng +3 more
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The CULt of Caspase-8 Ubiquitination [PDF]
Cell, 2009 Caspase-8 is activated at the plasma membrane by the death-inducing signaling complex (DISC). Jin et al. (2009) show that polyubiquitination of caspase-8, rather than targeting it for proteasomal degradation, is critical for sustaining caspase-8 activity after dissociation from the DISC.
Békés, Miklós, Salvesen, Guy S.
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Diagnostics, 2021 Ovarian cancer remains a major diagnostic and therapeutic problem in modern gynecological oncology. For this reason, research which focuses on the search for new diagnostic markers and the assessment of their possible usefulness in clinical practice is ...
Aleksandra Mielczarek-Palacz +2 more
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GENETIC POLYMORHISM OF CASPASE 8 AND 9 IN IRAQ
The Iraqi Journal of Agricultural science, 2022 This study examined the potential association between polymorphisms of Caspase 9 −293del (rs4645982) and Caspase8−652 6N ins / del (rs3834129) and the danger of acute and chronic myeloid leukaemia in Iraqi population.
Duaa Abdullah , Reema M. Aloubaidy
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Obesity Science & Practice, 2023 Mechanisms underlying the negative effects of obesity on the brain are still unknown. Obesity is associated with oxidative stress in the brain and neuroinflammation that promotes neurodegenerative diseases.
Erick Gómez‐Apo +4 more
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Serum Interleukin-13 and Caspase 8 are Elevated in Prurigo Nodularis
Acta Dermato-Venereologica, 2023 is missing (Short communication)
Teresa Ju +10 more
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Caspase‐8 in Apoptosis: The Beginning of “The End”? [PDF]
IUBMB Life, 2000 AbstractCaspase‐8 is a member of the cysteine proteases, which are implicated in apoptosis and cytokine processing. Like all caspases, caspase‐8 is synthesized as an inactive single polypeptide chain zymogen procaspase and is activated by proteolytic cleavage, through either autoactivation after recruitment into a multimeric complex or trans‐cleavage ...
M, Kruidering, G I, Evan
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