Results 11 to 20 of about 7,578,422 (291)
Cell Reports, 2017 Formation of the death-inducing signaling complex (DISC) initiates extrinsic apoptosis. Caspase-8 and its regulator cFLIP control death signaling by binding to death-receptor-bound FADD.
Sebastian Horn +9 more
doaj +9 more sources
Role of caspase-8 in thymus function [PDF]
Cell Death & Differentiation, 2013 The thymus is the primary organ responsible for de novo generation of immunocompetent T cells that have a diverse repertoire of antigen recognition. During the developmental process, 98% of thymocytes die by apoptosis. Thus apoptosis is a dominant process in the thymus and occurs through either death by neglect or negative selection or through ...
POZZESI, NICOLA +6 more
openaire +4 more sources
, 2016 Caspase-8 is a key initiator of apoptotic cell death where it functions as the apical protease in death receptor-mediated apoptosis triggered via the death-inducing signalling complex (DISC). However, the observation that caspase-8 is upregulated in many
IR Powley (7767545) +3 more
core +7 more sources
Frontiers in Pharmacology, 2022 Purpose: The incidence of uric acid (UA)-induced kidney injury is increasing owing to the high incidence of hyperuricemia in recent years. The flower of Abelmoschus manihot (Linneus) Medik is a traditional Chinese medicinal herb widely used in the ...
Zhihui Ding +14 more
doaj +1 more source
Virology Journal, 2012 Background Chronic hepatitis C (CHC) has emerged as a leading cause of cirrhosis in the U.S. and across the world. To understand the role of apoptotic pathways in hepatitis C virus (HCV) infection, we studied the mRNA and protein expression patterns of ...
Albertoni Guilherme +11 more
doaj +1 more source
An Apoptotic Caspase Network Safeguards Cell Death Induction in Pyroptotic Macrophages
Cell Reports, 2020 Summary: Pyroptosis has emerged as a key mechanism by which inflammasomes promote host defense against microbial pathogens and sterile inflammation. Gasdermin D (GSDMD)-mediated cell lysis is a hallmark of pyroptosis, but our understanding of cell death ...
Nathalia Moraes de Vasconcelos +6 more
doaj +1 more source
RIPK3 and caspase 8 collaborate to limit herpes simplex encephalitis.
PLoS Pathogens, 2022 Invasion of the brain by herpes simplex virus 1 (HSV1) can lead to the development of herpes simplex encephalitis (HSE) that is often associated with significant morbidity and mortality regardless of therapeutic intervention.
Hongyan Guo +3 more
doaj +1 more source
Effect of Gynura procumbens (Lour.) Merr. on the histopathology of the diabetic pancreas via caspase family expression [PDF]
Journal of Pharmacy & Pharmacognosy ResearchContext: Diabetes is a prominent cause of mortality globally, particularly in Indonesia. Elevated glucose levels stimulate insulin secretion from pancreatic β cells. A variety of drugs, including oral treatments and synthetic insulin, have been developed
Putri Cahaya Situmorang +4 more
doaj +1 more source
Korean Journal of Clinical Laboratory Science, 2021 Hypertriglyceridemia is the main risk factor for atherosclerosis. It is reported that triglyceride (TG) induces macrophage cell death, and is involved in the formation of plaques and development of atherosclerosis.
Byung Chul Jung +3 more
doaj +1 more source
Caspase-3/-6/-8 are required for Gsdme-dependent pyroptosis.
, 2022 a Images and cell viability of WT, Nlrp3-/-, Caspase-1-/- and Gsdmd-/- BMDMs left untreated or stimulated with ATP and silica. Arrowheads indicate pyroptotic cells. The scale bar represents 100 μm.
Yujie Zou (408340) +12 more
core +1 more source