Results 21 to 30 of about 301,273 (141)

Apoptotic Volume Decrease (AVD) Is Independent of Mitochondrial Dysfunction and Initiator Caspase Activation

Cells, 2012
Persistent cell shrinkage is a major hallmark of apoptotic cell death. The early-phase shrinkage, which starts within 30−120 min after apoptotic stimulation and is called apoptotic volume decrease (AVD), is known to be accomplished by activation of K ...
Takeshi Tsubata, Emi Maeno, Yasunobu Okada   +2 more
doaj   +1 more source

TNF-α contributes to sarcopenia through caspase-8/caspase-3/GSDME-mediated pyroptosis

Cell Death Discovery, 2023
Sarcopenia has become a leading cause of disability and mortality in the elderly. It has been reported that programmed cell death (PCD) is associated with the development of sarcopenia that is characterized by reduction of muscle fiber size and number ...
Jingying Wu, Siming Lin, Weixiao Chen, Guili Lian, Weibin Wu, Ai Chen, Mohammad Ismail Hajary Sagor, Li Luo, Huajun Wang, Liangdi Xie   +9 more
doaj   +1 more source

Caspase-8 but not caspase-7 influences inflammasome activation to act in control of Brucella abortus infection

Frontiers in Microbiology, 2022
Programmed cell death (PCD) is an important mechanism of innate immunity against bacterial pathogens. The innate immune PCD pathway involves the molecules caspase-7 and caspase-8, among others.
Raiany A. Santos, Daiane M. Cerqueira, Dario S. Zamboni, Sergio C. Oliveira, Sergio C. Oliveira, Sergio C. Oliveira   +5 more
doaj   +1 more source

Bcl-xL overexpression decreases GILZ levels and inhibits glucocorticoid-induced activation of caspase-8 and caspase-3 in mouse thymocytes

Journal of Translational Autoimmunity, 2020
Glucocorticoids promote thymocyte apoptosis and modulate transcription of numerous regulators of thymic apoptosis. Among these, glucocorticoid-induced leucine zipper (GILZ) is strongly upregulated in the thymus.
Isabella Muscari, Sabrina Adorisio, Anna Marina Liberati, Trinh Thi Thuy, Tran Van Sung, Lorenza Cannarile, Emira Ayroldi, Carlo Riccardi, Domenico V. Delfino   +8 more
doaj   +1 more source

Tyrosine Phosphorylation of Caspase-8 Abrogates Its Apoptotic Activity and Promotes Activation of c-Src. [PDF]

PLoS ONE, 2016
Src family tyrosine kinases (SFKs) phosphorylate caspase-8A at tyrosine (Y) 397 resulting in suppression of apoptosis. In addition, the phosphorylation of caspase-8A at other sites including Y465 has been implicated in the regulation of caspase-8 ...
Jennifer Ly Tsang, Song Hui Jia, Jean Parodo, Pamela Plant, Monika Lodyga, Emmanuel Charbonney, Katalin Szaszi, Andras Kapus, John C Marshall   +8 more
doaj   +1 more source

Non-apoptotic function of caspase-8 confers prostate cancer enzalutamide resistance via NF-κB activation

Cell Death and Disease, 2021
Caspase-8 is a unique member of caspases with a dual role in cell death and survival. Caspase-8 expression is often lost in some tumors, but increased in others, indicating a potential pro-survival function in cancer.
Jia Xia, Jiahui Zhang, Liangzhe Wang, Hailong Liu, Jie Wang, Junyan Liu, Zhaoqian Liu, Yingjian Zhu, Yingjie Xu, Wen Yang, Yongjiang Yu   +10 more
doaj   +1 more source

Atypical role of proximal caspase-8 in truncated Tau-induced neurite regression and neuronal cell death

Neurobiology of Disease, 2003
Abnormal Tau protein is known to be closely associated with several neurodegenerative diseases. Previously, we showed that Tau was cleaved by caspase-3 to generate the cleavage product lacking the C-terminus (ΔTau-1) during neuronal cell death.
Chul-Woong Chung, Yeon-Mi Hong, Sungmin Song, Ha-Na Woo, Yun-Hee Choi, Troy Rohn, Yong-Keun Jung   +6 more
doaj   +1 more source

Irisin Protects Against Hind Limb Ischemia Reperfusion Injury

Drug Design, Development and Therapy, 2021
Ayşegül Küçük,1,* Yücel Polat,2 Aydan Kılıçarslan,3 Nuran Süngü,3 Hakan Kartal,4 Ali Doğan Dursun,5,* Mustafa Arslan6 1Kutahya Health Sciences University, Medical Faculty, Department of Physiology, Kutahya ...
Küçük A, Polat Y, Kılıçarslan A, Süngü N, Kartal H, Dursun AD, Arslan M   +6 more
doaj  

Caspase‐8 Variant G Regulates Rheumatoid Arthritis Fibroblast‐Like Synoviocyte Aggressive Behavior

ACR Open Rheumatology, 2022
Objective Fibroblast‐like synoviocytes (FLS) play a pivotal role in rheumatoid arthritis (RA) by contributing to synovial inflammation and progressive joint damage. An imprinted epigenetic state is associated with the FLS aggressive phenotype.
Cecilia Ansalone, Richard I. Ainsworth, Gyrid Nygaard, Rizi Ai, Edward B. Prideaux, Deepa Hammaker, Narayanan B. Perumal, Ken Weichert, Frances Tung, Lalitha Kodandapani, J. Michael Sauder, Elisabeth C. Mertsching, Robert J. Benschop, David L. Boyle, Wei Wang, Gary S. Firestein   +15 more
doaj   +1 more source

Caspase-10 Negatively Regulates Caspase-8-Mediated Cell Death, Switching the Response to CD95L in Favor of NF-κB Activation and Cell Survival

Cell Reports, 2017
Formation of the death-inducing signaling complex (DISC) initiates extrinsic apoptosis. Caspase-8 and its regulator cFLIP control death signaling by binding to death-receptor-bound FADD.
Sebastian Horn, Michelle A. Hughes, Ramon Schilling, Carsten Sticht, Tencho Tenev, Michaela Ploesser, Pascal Meier, Martin R. Sprick, Marion MacFarlane, Martin Leverkus   +9 more
doaj   +1 more source