Results 141 to 150 of about 279,199 (293)

A caspase 8-cathepsin B protease cascade contributes to bile salt-induced hepatocyte apoptosis

, 1998
William A. Faubion, Patricia J. Roberts, Steve F. Bronk, L. B. Agellon, G. J. Gores   +4 more
openalex   +1 more source

MCT1‐mediated Lactate Shuttle to Mitochondria Governs Macrophage Polarization and Modulates Glucose Homeostasis by Affecting β Cells

Advanced Science, EarlyView.
This study demonstrates that the transport of lactate to the mitochondria is of critical importance in determining the functions of macrophages by altering mitochondrial respiration. In macrophages, this lactate transport mechanism regulates glucose homeostasis by influencing the functions of insulin‐secreting cells in the pancreatic islets.
Lingling Chen, Yijun Lin, Xinyu Zhu, Shixuan Zhuo, Zixuan Li, Cheng Guo, Xiaoyi Ye, Jinzhu Chen, Shuying Wang, Yan Chen   +9 more
wiley   +1 more source

Advances in Single‐Cell Sequencing for Infectious Diseases: Progress and Perspectives

Advanced Science, EarlyView.
Single‐cell sequencing technologies uncover novel, unknown, and emergent features of many diseases. This review describes recent progress of single‐cell sequencing technologies and their applications in infectious diseases, summarizes the underlying commonalities of different infections and discusses future research directions, facilitating the ...
Mengyuan Lyu, Yang Liu, Jian Zhou, Hongli Lai, Hongxia Ruan, Dongsheng Wu, Shun Zhu, Xudong Zhou, Wananqi Ma, Yuchen Huang, Shuting Lei, Han Luo, Jie Chen, Binwu Ying   +13 more
wiley   +1 more source

Integrated In Silico and In Vivo evaluation of Cassytha filiformis: Molecular insights into caspase-3/8 binding and wound healing effect

Pharmacological Research - Modern Chinese Medicine
Background: Cassytha filiformis is a parasitic vine traditionally used in Chinese traditional medicine (CTM) for its anti-inflammatory, detoxifying, and wound-healing properties.
Soosamma John, Nisha Shri Chengamaraju, Navya A S, Agasa Ramu Mahesh, Bincy Raj   +4 more
doaj  

Phosphatidylinositol 3′-Kinase Blocks CD95 Aggregation and Caspase-8 Cleavage at the Death-Inducing Signaling Complex by Modulating Lateral Diffusion of CD95 [PDF]

, 2001
Arun S. Varadhachary, Michael Edidin, Allison Hanlon, Marcus E. Peter, Peter H. Krammer, Padmini Salgame   +5 more
openalex   +1 more source

Apoptotic Bodies Restore NAD and Mitochondrial Homeostasis in Fibroblasts

Advanced Science, EarlyView.
Mesenchymal stem cell‐derived apoptotic bodies (MSC‐ABs) target keloid fibroblasts (KFs), restoring nicotinamide adenine dinucleotide (NAD) metabolism and mitochondrial function, suppressing collagen overproduction, and rebalancing tissue homeostasis, offering a novel therapy for keloid.
Shutong Qian, Siya Dai, Chunyi Guo, Wenjun Wang, Jiajia Pang, Yichen Shen, Mingyuan Xu, Jie Hu, Wenguo Cui, Xiaoming Sun, Jinghong Xu   +10 more
wiley   +1 more source

Expression of caspases-3, -6 and -8 and their relation to apoptosis in non-small cell lung carcinoma [PDF]

, 2001
Ulla T�rm�nen-N�p�nkangas, Ylermi Soini, Katriina Kahlos, Vuokko L. Kinnula, Paavo P��kk�   +4 more
openalex   +1 more source

Ultrasound‐Induced Nitric Oxide‐Propelled Nanomotor for Multimodal Theranostics of Cancer with Deep Penetration and Extended Lifetime

Advanced Science, EarlyView.
A hollow nanomotor (PM‐HMSN/Arg) propelled by ultrasound‐triggered nitric oxide (NO) was developed. The nanomotor employs a “tethering‐relaxing‐drilling” mechanism to overcome biological barriers, enabling multimodal theranostics of cancer with deep penetration and extended lifetime.
Xue Xu, Jinxu Cao, Yan Mu, Hao Zhang, Ya‐Lei Wang, Mengzhen Chen, Yuce Li, Qian Hua   +7 more
wiley   +1 more source

Alpha/Beta Interferons Potentiate Virus-Induced Apoptosis through Activation of the FADD/Caspase-8 Death Signaling Pathway

, 2000
Siddharth Balachandran, Paul C. Roberts, Todd Kipperman, Kapil N. Bhalla, Richard W. Compans, David R. Archer, Glen N. Barber   +6 more
openalex   +1 more source

Geranylgeraniol, an Intermediate Product in Mevalonate Pathway, Induces Apoptotic Cell Death in Human Hepatoma Cells: Death Receptor‐independent Activation of Caspase‐8 with Down‐regulation of Bcl‐xL Expression [PDF]

, 2001
Yoshio Takeda, Kazuhiko Nakao, Keisuke Nakata, Atsushi Kawakami, Hiroaki Ida, Tatsuki Ichikawa, Masaya Shigeno, Yuji Kajiya, Keisuke Hamasaki, Yuji Kato, Katsumi Eguchi   +10 more
openalex   +1 more source