Results 171 to 180 of about 335,290 (304)

Irgm1 Improves Postinfarction Cardiac Repair by Promoting Neutrophil Clearance and Efferocytosis

Advanced Science, EarlyView.
The Irgm1‐PDIA3 axis enhances post‐infarction cardiac repair by accelerating neutrophil clearance and facilitating efferocytosis. Irgm1 holds potential as a prognostic biomarker in MI, and LOC14 may represent a therapeutic option to improve cardiac repair, especially in cases of Irgm1 deficiency.
Zeng Wang, Lai Wei, Mingyang Wang, Shanjie Wang, Lili Xiu, Jiaxiang Sun, Rongzhe Lu, Yige Liu, Jiaxin Wang, Fengyi Liu, Weike Liu, Bo Yu, Yong Sun, Xueqin Gao, Shaohong Fang   +14 more
wiley   +1 more source

Lack of caspase 8 directs neuronal progenitor-like reprogramming and small cell lung cancer progression. [PDF]

Nat Commun
Androulidaki A, Liu F, Bebber CM, Kisis I, Sakthivelu V, Hunold P, Koerner L, Dahlhaus A, Yapici FI, Grimm C, Pacholewska A, Tishina S, Doskotz F, Torres Fernández LA, Stroh J, Abdallah AT, Beck J, Mulalic L, Schmitt A, Grüll H, Persigehl T, Quaas A, Peifer M, Brägelmann J, Reinhardt HC, Nieper P, Hänsel-Hertsch R, Thomas RK, George J, Schweiger MR, Pasparakis M, Beleggia F, von Karstedt S.   +32 more
europepmc   +1 more source

An Insulin‐Exosome‐TNFAIP8 Axis Drives Stromal Fibrosis and Therapeutic Resistance in Pancreatic Cancer

Advanced Science, EarlyView.
In pancreatic ductal adenocarcinoma (PDAC), insulin is associated with activation of PI3K/AKT–RAB3A signaling and enhanced secretion of TNFAIP8‐enriched exosomes from tumor cells. Uptake of these exosomes by fibroblasts is linked to TRIM21‐dependent STAT1 degradation and the emergence of myofibroblastic CAF–associated features, accompanied by increased
Zhenyu Li, Li Chen, Tao Wang, Haiyang Jiang, Huijuan Wang, Mengyu Li, Guanpeng Xie, Chunhua Xi, Han Yan, Chunhui Lu, Chenchen Li, Hanyu Zhu, Feihu Sun, Lingdi Yin, Jun Yu, Yi Miao   +15 more
wiley   +1 more source

Dysregulation of caspase-8 and caspase-9 in T-lymphocyte apoptosis: implications for pathogenesis, diagnosis, and therapeutic targeting in psoriatic arthritis. [PDF]

BMC Mol Cell Biol
Al-Rawaf HA, Gabr SA, Iqbal A, Alghadir AH.   +3 more
europepmc   +1 more source

Halofuginone is a Molecular Glue Degrader of Integrin β4

Advanced Science, EarlyView.
Integrin β4 overexpression is linked to aggressive tumors and poor prognosis, but targeted therapies are lacking. We identified halofuginone (HF) as a molecular glue degrader that promotes integrin β4 degradation via the CRL4BWDR18 E3 ligase. HF suppresses tumor progression in vitro and in vivo, offering a new strategy for targeting oncogenic ...
Wei Gong, Di Yang, Junrui Tian, Yufei Chai, Tiantian Yu, Qingnan Wu, Yan Wang, Weimin Zhang, Qimin Zhan   +8 more
wiley   +1 more source

Discovery of spectosis supports the key role of caspase-8 in determining the type of cell death in mature erythrocytes and erythrocyte death-driven immunogenicity. [PDF]

Cell Death Discov
Tkachenko A.
europepmc   +1 more source

Disulfide‐Bridged Ru Complex–Mediated Photo‐Disulfidptosis for Colorectal Cancer Therapy

Advanced Science, EarlyView.
In this work, a binuclear ruthenium complex, RuSSRu was developed for efficient colorectal cancer (CRC) treatment. The synergistic interaction between disulfidptosis and lysosomal damage‐induced apoptosis induced by RuSSRu amplified tumor cell death. This innovative approach offers a potent therapeutic strategy for CRC.
Simeng He, Wendong Jin, Jiaojiao Pang, Xiaoting Gong, Shixian Cao, Duo Mao, Yuguo Chen, Kang‐Nan Wang, Bin Liu   +8 more
wiley   +1 more source

Molybdenum and cadmium co-induced apoptosis and necroptosis via activating endoplasmic reticulum stress and upregulating Caspase-8 expression in duck hepatocytes. [PDF]

Poult Sci
Xiao L, Nie G, Dai X, Li S, Wang S, Le X, Ren J, Zhang C.   +7 more
europepmc   +1 more source

Targeting the GPX4–FUNDC1 Interaction with Magnesium Lithospermate B Attenuates Sepsis‐Associated Lung Injury

Advanced Science, EarlyView.
The diagram depicts the endothelial‐protective mechanism of magnesium lithospermate B (MLB) in sepsis‐associated lung injury. MLB binds GPX4 at Gly79, disrupts its interaction with FUNDC1, prevents mitophagy‐mediated GPX4 degradation, restores mitophagic flux, reduces ROS, and limits ferroptosis.
Zhixi Li, Chang Liu, Zhaoxue Ma, Dongyou Zheng, Renkai Wang, Yongjing Yu, Guangmin Chen, Chenglong Li, Yue Bu, Hang Cao, Bing Zhang   +10 more
wiley   +1 more source

RIOK2 kinase regulates the translocation of the FADD-RIPK1-Caspase-8 complex to the ER and the cleavage of Gasdermin D to drive pyroptosis. [PDF]

Nat Commun
Ma M, Wang F, Cui P, Zhang Y, Ma H, He Y, Cheng Y, Huang J, Wang J, Wu X, Yang H, Zheng R, Ma H, Cai Q, Wang L, Ge B.   +15 more
europepmc   +1 more source