Results 171 to 180 of about 280,711 (194)

Caspase-8 promotes scramblase-mediated phosphatidylserine exposure and fusion of osteoclast precursors

, 2022
Kronke G, Krishnacoumar B, Stenzel M, Garibagaoglu H, Omata Y, Sworn R, Ipseiz N, Czubala M, Stoll C, Böhm C, Herrmann M, Uderhardt S, Steffen U, Jenkins R, Taylor P, Zaiss M, Grüneboom A, Schett G, Scholtysek C.   +18 more
europepmc   +1 more source

The effect of caspase-8 as an apoptotic marker in relation to COVID-19 patients severity

, 2022
Eyada ZN, Al-Timimi RJM, alkubaisi h, Abdulateef Y..   +3 more
europepmc   +1 more source

Interferon alpha promotes caspase-8 dependent ultraviolet light-mediated keratinocyte apoptosis via interferon regulatory factor 1. [PDF]

Front Immunol
Loftus SN, Gharaee-Kermani M, Xu B, Moore TM, Hannoudi A, Mallbris MJ, Klein B, Gudjonsson JE, Kahlenberg JM.   +8 more
europepmc   +1 more source

ER stress elicits non-canonical CASP8 (caspase 8) activation on autophagosomal membranes to induce apoptosis. [PDF]

Autophagy
Hattori T, Fundora KA, Hamamoto K, Opozda DM, Liang X, Liu X, Zhang J, Uzun Y, Takahashi Y, Wang HG.   +9 more
europepmc   +1 more source

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Caspase-8 for Outer Harmony

Science Signaling, 2009
Ablation of caspase-8 in keratinocytes activates proliferative and inflammatory responses in the epidermis.
Sollberger, Gabriel, Beer, Hans-Dietmar
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From procaspase‐8 to caspase‐8: Revisiting structural functions of caspase‐8

Journal of Cellular Physiology, 2010
AbstractCaspase‐8 is well‐characterized to initiate an apoptotic pathway triggered by the external stimuli. The proximity‐driven model recently has been proposed to interpret the activation mechanism of caspase‐8 in so‐far unprecedent detail, in which dimerization, autocleavage, and inhibitor of caspase‐8 are indispensable. Intriguingly, death effector
Yang Zhao, Hong Ren, Xin Sui
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Caspase-8: The double-edged sword

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2020
Caspase-8 is a cysteine - aspartate specific protease that classically triggers the extrinsic apoptotic pathway, in response to the activation of cell surface Death Receptors (DRs) like FAS, TRAIL-R and TNF-R. Besides it's roles in triggering death receptor-mediated apoptosis, Caspase-8 has also been implicated in the onsets of anoikis, autophagy and ...
Klaus Strebhardt, Izabela Kostova, Sven Becker, Ranadip Mandal, Joan Compte Barrón   +4 more
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Two faces of caspase-8

Nature Immunology, 2002
A deficit of caspase-8 should presumably lead to over-activation of lymphocytes. A recent report in Nature from Lenardo's group, however, describes humans with a severe caspase-8 deficiency whose T cells, counter-intuitively, have impaired activation abilities.
Bryan C. Barnhart, Marcus E. Peter
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Non-apoptotic functions of caspase-8

Biochemical Pharmacology, 2008
Caspases are a family of aspartate-specific cysteine proteases that have been well characterized for their function in apoptosis signaling. Caspase-8 is implicated as an initiator caspase in death receptor-induced signaling to apoptosis and has been studied most extensively for its role in CD95-induced cell death.
Rudi Beyaert, Jonathan Maelfait
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Caspase‐8 Gene Expression in Neuroblastoma

Annals of the New York Academy of Sciences, 2004
Abstract: Neuroblastoma (NB) is a solid tumor of infancy that presents a high rate of spontaneous regression, a phenomenon that likely reflects the activation of an apoptotic/differentiation program. Indeed, the level of expression of molecules involved in the regulation of apoptosis, such as p73 or survivin, is a prognostic factor in NB patients. The
Ilaria Gelvi, Massimo Romani, Angela Di Vinci, Chiara Brignole, Silvano Ferrini, Ida Casciano, Michela Croce, Gabriella Pagnan, Giorgio Allemanni, Alessandro De Ambrosis, Mirco Ponzoni, Barbara Banelli   +11 more
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