Results 181 to 190 of about 6,024,904 (336)

Rewiring Neuroimmunity: Nanoplatform Innovations for CNS Disease Therapy

Advanced Therapeutics, EarlyView.
This review explores emerging nanoplatform strategies designed to modulate neuroimmune responses for treating central nervous system (CNS) disorders. It examines structural and microenvironmental barriers, advances in multifunctional and targeted nanotechnologies, and highlights clinical progress and translational challenges, offering insights into the
Muhammad Usman Akbar, Weiwei Guo, Xin Shen, Yimeng Fang, Yilin Liu, Peng‐Yuan Wang, Roey Elnathan, Yaping Chen   +7 more
wiley   +1 more source

Phosphatidylinositol 3′-Kinase Blocks CD95 Aggregation and Caspase-8 Cleavage at the Death-Inducing Signaling Complex by Modulating Lateral Diffusion of CD95 [PDF]

, 2001
Arun S. Varadhachary, Michael Edidin, Allison Hanlon, Marcus E. Peter, Peter H. Krammer, Padmini Salgame   +5 more
openalex   +1 more source

Expression of the initiator caspase-8 in the epithelium of physiological ectopy in young women, infected with Human papillomaviruses

Journal of Education, Health and Sport, 2018
More and more often clinical cases of severe cervical lesions and cervical cancer are observed against the background of physiological ectopy at a young age.
A. O. Patskov
doaj  

Understanding miR‐200c: an Important Player in Resistance to Cancer Treatment

Advanced Therapeutics, EarlyView.
How can one microRNA alter cancer's response to therapy? miR‐200c plays a central role in therapeutic resistance by modulating epithelial‐mesenchymal transition, apoptosis, cancer stemness features, and drug efflux. This review outlines the context‐dependent functions of miR‐200c in various cancers and highlights its potential as both a biomarker and a
Fatma Sanli, Omer Faruk Karatas
wiley   +1 more source

The structures of caspases-1, -3, -7 and -8 reveal the basis for substrate and inhibitor selectivity

, 2000
Yunyi Wei, Ted Fox, Steve P. Chambers, JoAnne Sintchak, Joyce T. Coll, Julian M.C. Golec, Lora Swenson, Keith P. Wilson, Paul S. Charifson   +8 more
openalex   +1 more source

Caspase-8

Definitions, 2020

semanticscholar   +1 more source

Lycium barbarum Glycopeptide Alleviates Neomycin‐Induced Ototoxicity by Inhibiting Tryptophan Hydroxylase‐Mediated Serotonin Biosynthesis

Advanced Science, EarlyView.
Lycium barbarum glycopeptide (LBGP), which is further extracted from Lycium barbarum polysaccharides, exhibits significant protective effects against neomycin‐induced hearing dysfunction including oxidative stress in cochlea and loss of key cells in cochlea.
Yunhao Wu, Li Zhang, Shengda Cao, Jingwen Zhang, Cheng Li, Yunlong Shan, Qiuping Liu, Zhexiong Yu, Qiaojun Fang, Yuhua Zhang, Xiaolong Fu, Kwok‐Fai So, Renjie Chai   +12 more
wiley   +1 more source

Alpha/Beta Interferons Potentiate Virus-Induced Apoptosis through Activation of the FADD/Caspase-8 Death Signaling Pathway

, 2000
Siddharth Balachandran, Paul C. Roberts, Todd Kipperman, Kapil N. Bhalla, Richard W. Compans, David R. Archer, Glen N. Barber   +6 more
openalex   +1 more source

Caspase 8-dependent sensitization of cancer cells to TRAIL-induced apoptosis following reovirus-infection [PDF]

, 2001
Penny Clarke, Suzanne M. Meintzer, Aaron C. Spalding, Gary L. Johnson, Kenneth L. Tyler   +4 more
openalex   +1 more source

Bilirubin Targeting WNK1 to Alleviate NLRP3‐Mediated Neuroinflammation

Advanced Science, EarlyView.
At physiological concentrations, bilirubin binds to the kinase domain of WNK1, thereby augmenting its activity and facilitating the phosphorylation of downstream SPAK/OSR1. This phosphorylation inhibits KCC2 activity, leading to elevate intracellular chloride levels in neurons.
Linfei Mao, Jiayu Lu, Quanjun Yang, Zhenqi Liu, Cuiping Wu, Bingbing Ke, Kaiyan Su, Haolin Yuan, Yaqi Cui, Yao Wang, Richard Salvi, Guang Yang, Shankai Yin, Feng Liu, Chunyan Li   +14 more
wiley   +1 more source