Results 311 to 320 of about 6,024,904 (336)
USP8‐Governed MDA5 Homeostasis Promotes Innate Immunity and Autoimmunity
Advanced Science, EarlyView.This study reveals that USP8 stabilizes MDA5 via AKT‐mediated phosphorylation (Ser718), enhancing their interaction and MDA5 deubiquitination. USP8 inactivation degrades MDA5, suppressing type I IFN and cytokine production. Pharmacological inhibition of USP8/AKT alleviates MDA5‐driven autoimmunity, demonstrating the USP8‐MDA5 axis as a therapeutic ...
Qimin Zhang +9 more
wiley +1 more source
A Novel nor@DHB Matrix for Direct Microbial Analysis in Lung Cancer Tissues
Advanced Science, EarlyView.Integrated matrix‐assisted laser desorption/ionization mass spectrometry workflow quantifies intratumoral microbes in lung cancer through lipopolysaccharide/lipid A extraction from biopsies. The novel ionic matrix called norharmane conjugated to 2,5‐dihydroxybenzoic acid enhances lipid A ionization, enabling direct detection of bacterial genera ...
Liang Shan +12 more
wiley +1 more source
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Science, 1998
Tumor necrosis factor alpha (TNF-alpha) binding to the TNF receptor (TNFR) potentially initiates apoptosis and activates the transcription factor nuclear factor kappa B (NF-kappaB), which suppresses apoptosis by an unknown mechanism. The activation of NF-
C. Y. Wang +4 more
semanticscholar +1 more source
Tumor necrosis factor alpha (TNF-alpha) binding to the TNF receptor (TNFR) potentially initiates apoptosis and activates the transcription factor nuclear factor kappa B (NF-kappaB), which suppresses apoptosis by an unknown mechanism. The activation of NF-
C. Y. Wang +4 more
semanticscholar +1 more source
Intestinal Inflammation and Dysregulated Immunity in Patients With Inherited Caspase-8 Deficiency.
Gastroenterology, 2019Caspase-8 (CASP8) is a protease that initiates apoptosis and regulates inflammation and immune responses. We identified germline mutations in CASP8 in 3 unrelated patients with infant-onset inflammatory bowel disease: 2 patients were homozygous for the ...
Anna S. Lehle +31 more
semanticscholar +1 more source
Ripoptosome Analysis by Caspase-8 Coimmunoprecipitation
Cold Spring Harbor Protocols, 2016The biochemical signaling of cell death pathways is executed at a number of different intracellular and/or membrane-bound high-molecular mass complexes. It is crucial to be able to detect the formation, differences in assembly, and differential composition of such complexes to understand their contribution to the execution phase of apoptotic or ...
Maria Feoktistova +2 more
openaire +3 more sources
Interferon-γ induces caspase-8 in neuroblastomas without affecting methylation of caspase-8 promoter
Journal of Pediatric Surgery, 2004The expression of caspase-8, a cysteine protease that is crucial for the apoptotic cascade, is absent in a high percentage of neuroblastomas, the most frequent extracranial solid tumor of infants and children. Resistance of neuroblastomas to death-receptor (eg, tumor necrosis factor alpha (TNF-alpha) receptor)--mediated apoptosis is thought to be ...
Dai H. Chung +3 more
openaire +3 more sources
Journal of Cellular Biochemistry, 2018
Ischemic stroke causes severe brain damage and remains one of the leading causes of morbidity and mortality worldwide. The microRNA‐134 (miR‐134) is involved in regulating the process of ischemia injury in neural cells and brain with ischemia stroke. The
Yilei Xiao +5 more
semanticscholar +1 more source
Ischemic stroke causes severe brain damage and remains one of the leading causes of morbidity and mortality worldwide. The microRNA‐134 (miR‐134) is involved in regulating the process of ischemia injury in neural cells and brain with ischemia stroke. The
Yilei Xiao +5 more
semanticscholar +1 more source
The Caspase-8 Modulator c-FLIP
Critical Reviews in Immunology, 2005Death receptors belong to the tumor necrosis factor receptor superfamily and can induce apoptosis through activation of procaspase-8. The cellular FLICE-inhibitory protein (c-FLIP) is able to modulate activation of procaspase-8 and thereby prevents induction of apoptosis mediated by death receptors.
openaire +3 more sources
Anti-inflammatory Functions of Caspase-8
2010Explorations of the functions of receptors of the TNF/NGF family have led to the discovery of various signaling proteins, many of which were later found to mediate effects of other inducers as well. We now have quite detailed knowledge of the mechanisms and molecular complexes by which some of the signaling proteins mediate these additional effects ...
David Wallach +6 more
openaire +3 more sources
Caspase-8 sumoylation is associated with nuclear localization [PDF]
Oncogene, 2005 The cysteine protease caspase-8 plays a pivotal role in the initiation of different apoptotic pathways and controls the maturation and differentiation of various cell types including neurons, fibroblasts and lymphocytes. Specific substrates of caspase-8 are present in both the cytoplasm and the nucleus, which may determine the ultimate biological ...
Jacques Camonis +7 more
openaire +2 more sources