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Caspase-8 in cancer biology and therapy
Cancer Letters, 2009Caspase-8 belongs to the caspase family of proteases and plays a key role in the regulation of programmed cell death (apoptosis) during normal development as well as in adult life. Since signaling via the death receptor (extrinsic) pathway critically depends on caspase-8, the disturbance of caspase-8 expression or function may contribute to human ...
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Molecular cloning and characterization of mouse caspase‐8
European Journal of Biochemistry, 1998Fas (APO‐1/CD95) is a transmembrane receptor protein which induces apoptosis upon activation. In apoptosis triggered by Fas, a subset of cysteine proteases designated caspases is activated, playing a central role as effector molecules. Among these caspases, human caspase‐8 (FLICE/MACH/Mch5) has been isolated and shown to be indispensable for Fas ...
Shin Yonehara +2 more
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Caspase-8 is a player in pyroptosis
Science, 2018Immunology The activation of certain pattern-recognition receptors by pathogen-associated molecular patterns results in the formation of inflammasome complexes. Inflammasome complexes can initiate both the maturation of inflammatory cytokines and pyroptotic cell death via the caspase-mediated cleavage of gasdermin D (GSDMD).
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Role of Proteolysis in Caspase-8 Activation and Stabilization
Biochemistry, 2007Caspase-8 is an apoptotic protease that is activated at the cytosolic face of the cell membrane. Activation relies on adaptor-induced dimerization of monomeric caspase-8 and is followed by specific limited autoproteolysis of the linker which separates the two subunits of the catalytic domain.
Douglas R. Green +3 more
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Potentiation of neuroblastoma metastasis by loss of caspase-8
Nature, 2006Neuroblastoma, the most common paediatric solid tumour, arises from defective neural crest cells. Genetic alterations occur frequently in the most aggressive neuroblastomas. In particular, deletion or suppression of the proapoptotic enzyme caspase-8 is common in malignant, disseminated disease, although the effect of this loss on disease progression is
David A. Cheresh +7 more
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Caspase 8 and Human Villous Cytotrophoblast Differentiation
Placenta, 2010The fusion of villous cytotrophoblast into the placental syncytium is the quintessential process in maintenance of a healthy pregnancy. Efficient fusion requires a phosphatidylserine (PS)-rich cytotrophoblast surface, expression of fusion proteins, cessation of cell cycling, and rearrangement of cytoskeleton to accommodate membrane joining. Significant
L. Luo +3 more
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The role of caspase-8 in resistance to cancer chemotherapy
Drug Resistance Updates, 2001Toxicity of chemotherapeutic agents against cancer cells is mediated through the initiation of programmed cell death. Apoptosis is an evolutionarily conserved cascade of intracellular proteolytic events propagated by a family of cysteine proteases called caspases. Many receptor- and non-receptor-mediated death signals induce apoptosis via activation of
Dai-Wu Seol +2 more
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Activation and Inactivation of Caspase-8 by Ubiquitylation
Science Signaling, 2013Whereas Cullin3-mediated ubiquitylation of caspase-8 promotes its activation, ubiquitylation by TRAF2 promotes its degradation.
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Integration of innate immune signalling by caspase-8 cleavage of N4BP1
Nature, 2020Alexander D. Gitlin +24 more
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Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis
Nature, 2019Melanie Fritsch +13 more
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