Results 301 to 310 of about 324,387 (342)

Stereoselective Biotransformation: Transfer of Learning to Advance Drug Metabolism and Biocatalysis

Angewandte Chemie, EarlyView.
Understanding stereoselective biotransformations has implications for predicting drug disposition and response and may also inspire novel biocatalytic and biomimetic strategies to address challenges in metabolite and API synthesis. ABSTRACT Chirality is an important determinant of drug action, as enantiomers can exhibit markedly different ...
Grace A. Okunlola, Godwin A. Aleku
wiley   +2 more sources

Predominance of Ferroptotic Cell Death Mechanisms in Substantia Nigra Neurodegeneration in Parkinson's Disease

Annals of Neurology, EarlyView.
Objective The extent of neuronal loss in Parkinson's disease (PD) and the pathogenic processes underlying neuronal dysfunction and loss remain poorly understood. Here, we analyzed the expression of key molecules representing different cell death signaling pathways and their association with Lewy pathology, dopaminergic (DA) neuron loss and stage of PD ...
Yue Jing Heng, Anusha Jayaraman, Richard Reynolds, Jia Nee Foo   +3 more
wiley   +1 more source

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Caspase-9 regulation: An update

Apoptosis, 2004
The complex sequence of events leading to apoptotic cell death is governed by an elaborate regulatory scheme involving the actions of both initiator and executioner proteases. Among the most intensively studied of the initiator caspases is caspase-9, an essential throughput element in the so-called intrinsic or mitochondrially gated pathway of ...
C R, Johnson, W D, Jarvis
openaire   +2 more sources

Akt Phosphorylation Site Found in Human Caspase-9 Is Absent in Mouse Caspase-9

Biochemical and Biophysical Research Communications, 1999
Caspase-9 is one caspase upstream of caspase-3 and its activation is stimulated by Apaf-1/cytochrome c and inhibited by Akt signals. BAD phosphorylation by Akt is an essential step for growth factor-mediated inhibition of caspase activation. Recently, it was shown that human caspase-9 is phosphorylated by Akt and that its protease activity is reduced ...
E, Fujita, A, Jinbo, H, Matuzaki, H, Konishi, U, Kikkawa, T, Momoi   +5 more
openaire   +2 more sources

Delineation of the caspase-9 signaling cascade

Apoptosis, 2007
In the intrinsic apoptosis pathway, mitochondrial disruption leads to the release of multiple apoptosis signaling molecules, triggering both caspase-dependent and -independent cell death. The release of cytochrome c induces the formation of the apoptosome, resulting in caspase-9 activation.
Alan D, Guerrero, Min, Chen, Jin, Wang
openaire   +2 more sources

Caspase-9

The International Journal of Biochemistry & Cell Biology, 2000
Caspase-9 is a member of caspase family of cysteine proteases that have been implicated in apoptosis and cytokine processing. When cells receive apoptotic stimuli, mitochondria releases cytochrome c which then binds to Apaf-1, the mammalian Ced-4 homologue, together with dATP.
openaire   +2 more sources

Caspase 9 is decreased in psoriatic epidermis

Acta Histochemica, 2006
Psoriasis is a proliferative and inflammatory disease of the skin. Caspase 9 is responsible for initiating the caspase activation cascade during apoptosis. Apoptosis is a physiological mechanism of homeostasis and development, and caspases are the executioners of apoptosis.
Oemeroglu, SUNA, Oeztas, MURAT ORHAN, Guerer, Mehmet Ali, Alli, Nuran, Oeztas, Pinar, Lortlar, Nese   +5 more
openaire   +3 more sources

Caspase-9 inhibition decreases expression of Mmp9 during chondrogenesis

Histochemistry and Cell Biology, 2022
Besides cell death, caspase-9 participates in non-apoptotic events, including cell differentiation. To evaluate a possible impact on the expression of chondrogenic/osteogenic factors, a caspase-9 inhibitor was tested in vitro. For this purpose, mouse forelimb-derived micromass cultures, the most common chondrogenic in vitro model, were used.
A. Ramesova, B. Vesela, E. Svandova, H. Lesot, E. Matalova   +4 more
openaire   +2 more sources

Expression of phosphorylated caspase‐9 in gastric carcinomas

APMIS, 2007
Alterations of caspases, the main executioners of apoptosis, have been described in human cancers. Caspase‐9 plays a crucial role in the initiation phase of the intrinsic apoptosis pathway. Caspase‐9 is phosphorylated at Thr125 through the mitogen‐activated protein kinase (MAPK) pathway, and this phosphorylation is associated with inhibition of caspase‐
Nam Jin, Yoo, Sung Hak, Lee, Eun Goo, Jeong, Sug Hyung, Lee   +3 more
openaire   +2 more sources

Caspase 9: context-dependent killer

Trends in Cell Biology, 1998
Abstract KUIDA, K. et al . (1998) Reduced apoptosis and cytochrome c -mediated caspase activation in mice lacking caspase 9 Cell 94, 325–337 Hakem, R. et al .
openaire   +1 more source