Results 311 to 320 of about 324,387 (342)

cDNA cloning and promoter analysis of rat caspase-9

Biochemical Journal, 2001
Caspase-9 is the apex caspase of the mitochondrial pathway of apoptosis, which plays a critical role in apoptotic initiation and progression. However, gene regulation of caspase-9 is largely unknown. This is in part due to the lack of information on the gene promoter.
J, Nishiyama, X, Yi, M A, Venkatachalam, Z, Dong   +3 more
openaire   +2 more sources

Caspase-9 activation in hypoxic human corneal epithelial cells

Apoptosis, 2003
The purpose of this study was to determine the effect of hypoxia on caspase-8 and -9 gene and protein expression and activity in corneal epithelium. Non-transformed human corneal epithelial cells (HCEC) were cultured in 2% oxygen. A cDNA expression array coupled with densitometric analysis was used to compare relative mRNA expression levels of 96 ...
M, Kurpakus-Wheater, R, Sexton, M L, McDermott, L K, Mrock, G, Sosne   +4 more
openaire   +2 more sources

Regulation of Cell Death Protease Caspase-9 by Phosphorylation

Science, 1998
Caspases are intracellular proteases that function as initiators and effectors of apoptosis. The kinase Akt and p21-Ras, an Akt activator, induced phosphorylation of pro–caspase-9 (pro-Casp9) in cells. Cytochrome c–induced proteolytic processing of pro-Casp9 was defective in cytosolic extracts from cells expressing either active Ras or Akt.
M H, Cardone, N, Roy, H R, Stennicke, G S, Salvesen, T F, Franke, E, Stanbridge, S, Frisch, J C, Reed   +7 more
openaire   +2 more sources

Caspase-9 as a therapeutic target for treating cancer

Expert Opinion on Therapeutic Targets, 2014
Caspase-9 is the apoptotic initiator protease of the intrinsic or mitochondrial apoptotic pathway, which is activated at multi-protein activation platforms. Its activation is believed to involve homo-dimerization of the monomeric zymogens. It binds to the apoptosome to retain substantial catalytic activity.
Bonglee, Kim, Sanjay K, Srivastava, Sung-Hoon, Kim   +2 more
openaire   +2 more sources

Cytochrome C and Caspase-9 Expression in Huntington 's Disease

NeuroMolecular Medicine, 2002
There is increasing evidence implicating apoptosis-mediated cell death in the pathogenesis of neurodegenerative diseases. One important event in the apoptotic cascade is the release of cytochrome c by mitochondria into the cytoplasm, activating caspase-9, leading to the subsequent activation of downstream executioner caspases.
Tamara, Kiechle, Alpaslan, Dedeoglu, James, Kubilus, Neil W, Kowall, M Flint, Beal, Robert M, Friedlander, Steven M, Hersch, Robert J, Ferrante   +7 more
openaire   +2 more sources

Caspase-9

2013
Bram J. van Raam, Guy S. Salvesen
openaire   +1 more source

Recognition and maturation of IL-18 by caspase-4 noncanonical inflammasome

Nature, 2023
Yanjie Hou, Jingjin Ding, Shao Feng
exaly  

Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Defense

Cell, 2020
Min Zheng, Rajendra Karki, Peter Vogel
exaly  

Molecular mechanisms of caspase regulation during apoptosis

Nature Reviews Molecular Cell Biology, 2004
Yigong Shi
exaly  

It cuts both ways: reconciling the dual roles of caspase 8 in cell death and survival

Nature Reviews Molecular Cell Biology, 2011
Andrew Oberst, Douglas R Green
exaly